MED18 - mediator complex subunit 18 Gene

Homo sapiens

Also known as SRB5; p28b

Gene ID: 54797 | Gene type: protein coding

About MED18

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:28,329,040-28,335,965 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele and 197 orthologues. Ubiquitous expression in colon (RPKM 5.4), lymph node (RPKM 4.8) and 25 other tissues.

Summary

MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]

MED18 Products(2)

mRNA	Protein	Name
NM_001127350.2	NP_001120822.1	mediator of RNA polymerase II transcription subunit 18
NM_017638.3	NP_060108.2	mediator of RNA polymerase II transcription subunit 18

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12584197	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of core mediator complex	IPI IPI: Inferred from physical interaction	24882805	GOA
part of mediator complex	IDA IDA: Inferred from direct assay	14638676	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24882805	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED18 Protein Structure

Med18

0
100
208 a.a.

Protein Preferred Names

Protein Names

mediator of RNA polymerase II transcription subunit 18

TRAP/mediator complex subunit p28b

MED18 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MED18	Q9BUE0	HOMEZ	Homo sapiens	Q8IX15-3	Y2H Prey Pooling	25416956
Intra	MED18	Q9BUE0	CAMK2B	Homo sapiens	Q13554	Y2H Prey Pooling	25416956
Intra	MED18	Q9BUE0	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	MED18	Q9BUE0	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	MED18	Q9BUE0	TRIM39	Homo sapiens	Q9HCM9-2	Validated Y2H	32296183
Intra	MED18	Q9BUE0	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Array	32296183
Intra	MED18	Q9BUE0	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Prey Pooling	32296183
Intra	MED18	Q9BUE0	MED17	Homo sapiens	Q9NVC6	Anti Tag CoIP	28514442
Intra	MED18	Q9BUE0	MED17	Homo sapiens	Q9NVC6	Anti Tag CoIP	35271311
Intra	MED18	Q9BUE0	MED17	Homo sapiens	Q9NVC6	Anti Tag CoIP	33961781
Intra	MED18	Q9BUE0	MED17	Homo sapiens	Q9NVC6	TAP	24981860
Intra	MED18	Q9BUE0	MED17	Homo sapiens	Q9NVC6	Anti Tag CoIP	24882805
Intra	MED18	Q9BUE0	MED6	Homo sapiens	O75586	Anti Tag CoIP	33961781
Intra	MED18	Q9BUE0	MED6	Homo sapiens	O75586	TAP	24981860
Intra	MED18	Q9BUE0	MED6	Homo sapiens	O75586	Anti Tag CoIP	28514442
Intra	MED18	Q9BUE0	MED6	Homo sapiens	O75586	Anti Tag CoIP	24882805
Intra	MED18	Q9BUE0	MED20	Homo sapiens	Q9H944	Complementation	32296183
Intra	MED18	Q9BUE0	MED20	Homo sapiens	Q9H944	Validated Y2H	25416956
Intra	MED18	Q9BUE0	MED20	Homo sapiens	Q9H944	Anti Tag CoIP	28514442
Intra	MED18	Q9BUE0	MED20	Homo sapiens	Q9H944	Validated Y2H	32296183
Intra	MED18	Q9BUE0	MED20	Homo sapiens	Q9H944	Anti Tag CoIP	33961781
Intra	MED18	Q9BUE0	MED20	Homo sapiens	Q9H944	MAPPIT	32296183
Intra	MED18	Q9BUE0	MED20	Homo sapiens	Q9H944	Y2H Array	31515488
Intra	MED18	Q9BUE0	MED20	Homo sapiens	Q9H944	MAPPIT	25416956
Intra	MED18	Q9BUE0	MED20	Homo sapiens	Q9H944	Anti Tag CoIP	25416956
Intra	MED18	Q9BUE0	MED20	Homo sapiens	Q9H944	Y2H Prey Pooling	32296183
Intra	MED18	Q9BUE0	MED20	Homo sapiens	Q9H944	Anti Tag CoIP	35271311
Intra	MED18	Q9BUE0	MED20	Homo sapiens	Q9H944	Y2H Array	25416956
Intra	MED18	Q9BUE0	MED20	Homo sapiens	Q9H944	Y2H Array	32296183
Intra	MED18	Q9BUE0	MED20	Homo sapiens	Q9H944	TAP	24981860
Intra	MED18	Q9BUE0	MED29	Homo sapiens	Q9NX70	Anti Tag CoIP	33961781
Intra	MED18	Q9BUE0	MED29	Homo sapiens	Q9NX70	Anti Tag CoIP	28514442
Intra	MED18	Q9BUE0	MED29	Homo sapiens	Q9NX70	Anti Tag CoIP	35271311
Intra	MED18	Q9BUE0	MED22	Homo sapiens	Q15528	Anti Tag CoIP	35271311
Intra	MED18	Q9BUE0	MED22	Homo sapiens	Q15528	TAP	24981860
Intra	MED18	Q9BUE0	MED22	Homo sapiens	Q15528	Anti Tag CoIP	33961781
Intra	MED18	Q9BUE0	MED22	Homo sapiens	Q15528	Anti Tag CoIP	24882805
Cross	MED18	Q9BUE0	Med20	Mus musculus	Q9R0X0	Anti Tag CoIP	12584197
Intra	MED18	Q9BUE0	TRIM39	Homo sapiens	Q9HCM9	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08289	MED18 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MED18	VGNC	VGNC:31355
Macaca mulatta	MED18	VGNC	VGNC:74587
Mus musculus	MED18	MGD	MGI:1914469
Canis familiaris	MED18	VGNC	VGNC:43127
Rattus norvegicus	MED18	RGD	RGD:1592757

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