BAG5 - BAG cochaperone 5 Gene

Homo sapiens

Also known as BAG-5; CMD2F

Gene ID: 9529 | Gene type: protein coding

About BAG5

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:103,556,551-103,562,657 (from NCBI)

This gene has 3 transcripts (splice variants), 204 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in testis (RPKM 41.2), thyroid (RPKM 15.2) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell Apoptosis and growth related proteins including Bcl-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/HSP70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

BAG5 Products(3)

mRNA	Protein	Name
NM_001015048.3	NP_001015048.1	BAG family molecular chaperone regulator 5
NM_001015049.5	NP_001015049.2	BAG family molecular chaperone regulator 5
NM_004873.4	NP_004864.1	BAG family molecular chaperone regulator 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24510904	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	24475098	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	15603737	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	24270810	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	24510904	GOA
involved in negative regulation of neuron projection development	IDA IDA: Inferred from direct assay	24510904	GOA
involved in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	24475098	GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	24475098	GOA
involved in negative regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	25006867	GOA
involved in negative regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	24475098	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	25006867	GOA
involved in regulation of inclusion body assembly	IMP IMP: Inferred from mutant phenotype	15603737	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	24510904	GOA
located in inclusion body	IDA IDA: Inferred from direct assay	15603737	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	24475098	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24510904	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15603737	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BAG5 Protein Structure

BAG

0
100
200
300
400
447 a.a.

Protein Preferred Names

Protein Names

BAG family molecular chaperone regulator 5

BCL2 associated athanogene 5

Related Diseases

Diseases

Alias

Cardiomyopathy, Dilated, 2f

CMD2F	Dilated Cardiomyopathy 2f
Cardiomyopathy, Dilated 2f

Familial Isolated Dilated Cardiomyopathy

Familial Or Idiopathic Dilated Cardiomyopathy

Spinocerebellar Ataxia, Autosomal Recessive 16

Autosomal Recessive Spinocerebellar Ataxia 16	SCAR16
Autosomal Recessive Cerebellar Ataxia Due To Stub1 Deficiency	Spinocerebellar Ataxia Autosomal Recessive Type 16
Spinocerebellar Ataxia, Autosomal Recessive, 16	Ataxia, Spinocerebellar, Autosomal Recessive, Type 16

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01346	BAG5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BAG5	VGNC	VGNC:26409
Canis familiaris	BAG5	VGNC	VGNC:38367
Rattus norvegicus	BAG5	RGD	RGD:1310847
Macaca mulatta	BAG5	VGNC	VGNC:70221
Felis catus	BAG5	VGNC	VGNC:81031
Mus musculus	BAG5	MGD	MGI:1917619

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