MAD1L1 - mitotic arrest deficient 1 like 1 Gene

Homo sapiens

Also known as MAD1; PIG9; TP53I9; TXBP181

Gene ID: 8379 | Gene type: protein coding

About MAD1L1

Cytogenetic location: 7p22.3 Genomic coordinates (GRCh38): 7:1,815,795-2,232,945 (from NCBI)

This gene has 23 transcripts (splice variants), 194 orthologues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 4.4), spleen (RPKM 4.1) and 25 other tissues.

Summary

MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

MAD1L1 Products(6)

mRNA	Protein	Name
NM_001013836.2	NP_001013858.1	mitotic spindle assembly checkpoint protein MAD1 isoform a
NM_001013837.2	NP_001013859.1	mitotic spindle assembly checkpoint protein MAD1 isoform a
NM_001304523.2	NP_001291452.1	mitotic spindle assembly checkpoint protein MAD1 isoform a
NM_001304524.2	NP_001291453.1	mitotic spindle assembly checkpoint protein MAD1 isoform b precursor
NM_001304525.2	NP_001291454.1	mitotic spindle assembly checkpoint protein MAD1 isoform c
NM_003550.3	NP_003541.2	mitotic spindle assembly checkpoint protein MAD1 isoform a

MAD1L1 Protein Structure

MAD

0
200
400
600
718 a.a.

Protein Preferred Names

Protein Names

mitotic spindle assembly checkpoint protein MAD1

MAD1 mitotic arrest deficient like 1

Related Diseases

Diseases

Alias

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Retroperitoneum Carcinoma

Retroperitoneal Cancer	Malignant Neoplasm Of Retroperitoneum And Peritoneum
Retroperitoneal Neoplasms	Carcinoma Of Retroperitoneum
Carcinoma Of The Retroperitoneum	Malignant Neoplasm Of Retroperitoneum
Malignant Retroperitoneal Cancer	Malignant Tumor Of Peritoneum And Retroperitoneum
Neoplasm Of Retroperitoneum	Neoplasm Of The Retroperitoneum
Retroperitoneal Neoplasm	Tumor Of Retroperitoneum
Malignant Retroperitoneal Tumour	Primary Malignant Neoplasm Of Retroperitoneum
Retroperitoneum Cancer

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07948	MAD1L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MAD1L1	VGNC	VGNC:74471
Bos taurus	MAD1L1	VGNC	VGNC:31130
Canis familiaris	MAD1L1	VGNC	VGNC:42914
Mus musculus	MAD1L1	MGD	MGI:1341857
Rattus norvegicus	MAD1L1	RGD	RGD:1596881
Felis catus	MAD1L1	VGNC	VGNC:68124

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