2. Gene
  3. MAD1L1 - mitotic arrest deficient 1 like 1 Gene

MAD1L1 - mitotic arrest deficient 1 like 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MAD1; PIG9; TP53I9; TXBP181

Gene ID: 8379 | Gene type: protein coding

About MAD1L1

Cytogenetic location: 7p22.3 Genomic coordinates (GRCh38): 7:1,815,795-2,232,945 (from NCBI)

This gene has 23 transcripts (splice variants), 194 orthologues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 4.4), spleen (RPKM 4.1) and 25 other tissues.

Summary

MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

MAD1L1 Products(6)

mRNA Protein Name
NM_001013836.2 NP_001013858.1 mitotic spindle assembly checkpoint protein MAD1 isoform a
NM_001013837.2 NP_001013859.1 mitotic spindle assembly checkpoint protein MAD1 isoform a
NM_001304523.2 NP_001291452.1 mitotic spindle assembly checkpoint protein MAD1 isoform a
NM_001304524.2 NP_001291453.1 mitotic spindle assembly checkpoint protein MAD1 isoform b precursor
NM_001304525.2 NP_001291454.1 mitotic spindle assembly checkpoint protein MAD1 isoform c
NM_003550.3 NP_003541.2 mitotic spindle assembly checkpoint protein MAD1 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables kinetochore binding IDA
IDA: Inferred from direct assay
18981471 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12006501 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cytoplasmic sequestering of protein IDA
IDA: Inferred from direct assay
19010891 GOA
involved in deactivation of mitotic spindle assembly checkpoint IDA
IDA: Inferred from direct assay
19010891 GOA
involved in mitotic spindle assembly checkpoint signaling IDA
IDA: Inferred from direct assay
18981471 GOA
involved in mitotic spindle assembly checkpoint signaling IMP
IMP: Inferred from mutant phenotype
9546394 GOA
involved in positive regulation of mitotic cell cycle spindle assembly checkpoint IDA
IDA: Inferred from direct assay
22898774 GOA
involved in positive regulation of mitotic cell cycle spindle assembly checkpoint IMP
IMP: Inferred from mutant phenotype
36322655 GOA
involved in regulation of metaphase plate congression IDA
IDA: Inferred from direct assay
20133940 GOA
Cellular Component GO Annotation Evidence Reference Source
part of MAD1 complex IPI
IPI: Inferred from physical interaction
22493223 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
19010891 GOA
colocalizes with kinetochore IDA
IDA: Inferred from direct assay
17363900 GOA
located in kinetochore IDA
IDA: Inferred from direct assay
20133940 GOA
located in mitotic spindle IDA
IDA: Inferred from direct assay
20133940 GOA
part of mitotic spindle assembly checkpoint MAD1-MAD2 complex IPI
IPI: Inferred from physical interaction
12006501 GOA
colocalizes with mitotic spindle pole IDA
IDA: Inferred from direct assay
22351768 GOA
colocalizes with nuclear envelope IDA
IDA: Inferred from direct assay
22351768 GOA
located in nuclear envelope IDA
IDA: Inferred from direct assay
22493223 GOA
part of nuclear pore nuclear basket IDA
IDA: Inferred from direct assay
18981471 GOA
located in nucleus IDA
IDA: Inferred from direct assay
19010891 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAD1L1 Protein Structure

MAD

MAD: Mitotic checkpoint protein (3 - 716)

  • 0
  • 200
  • 400
  • 600
  • 718 a.a.
Protein Preferred Names Protein Names

mitotic spindle assembly checkpoint protein MAD1

MAD1 mitotic arrest deficient like 1

MAD1L1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MAD1L1 Q9Y6D9 CCHCR1 Homo sapiens Q8TD31-3
Validated Y2H
25416956
Intra
MAD1L1 Q9Y6D9 TPM3 Homo sapiens Q5VU62
Y2H Prey Pooling
25416956
Intra
MAD1L1 Q9Y6D9 TPM3 Homo sapiens Q5VU62
Validated Y2H
25416956
Intra
MAD1L1 Q9Y6D9 LGALSL Homo sapiens Q3ZCW2
Y2H Array
25416956
Intra
MAD1L1 Q9Y6D9 TSC22D3 Homo sapiens Q99576-3
Y2H Array
25416956
Intra
MAD1L1 Q9Y6D9 YJU2 Homo sapiens Q9BW85
Validated Y2H
25416956
Intra
MAD1L1 Q9Y6D9 YJU2 Homo sapiens Q9BW85
Y2H Array
25416956
Intra
MAD1L1 Q9Y6D9 USP15 Homo sapiens Q9Y4E8
Validated Y2H
25416956
Intra
MAD1L1 Q9Y6D9 USP15 Homo sapiens Q9Y4E8
Y2H Array
25416956
Intra
MAD1L1 Q9Y6D9 MFAP1 Homo sapiens P55081
Validated Y2H
25416956
Intra
MAD1L1 Q9Y6D9 TPR Homo sapiens P12270
Anti Bait CoIP
24581499
Intra
MAD1L1 Q9Y6D9 CENPE Homo sapiens Q02224
Pull Down
26258632
Intra
MAD1L1 Q9Y6D9 CENPE Homo sapiens Q02224
Anti Bait CoIP
26258632
Intra
MAD1L1 Q9Y6D9 CAPN7 Homo sapiens Q9Y6W3
Validated Y2H
32296183
Intra
MAD1L1 Q9Y6D9 HAUS1 Homo sapiens Q96CS2
Y2H Prey Pooling
25416956
Intra
MAD1L1 Q9Y6D9 HAUS1 Homo sapiens Q96CS2
Y2H Array
25416956
Intra
MAD1L1 Q9Y6D9 NEBL Homo sapiens O76041
Y2H Array
25416956
Intra
MAD1L1 Q9Y6D9 NEBL Homo sapiens O76041
Y2H Prey Pooling
25416956
Intra
MAD1L1 Q9Y6D9 NEBL Homo sapiens O76041
Y2H Array
31515488
Intra
MAD1L1 Q9Y6D9 NEBL Homo sapiens O76041
Validated Y2H
25416956
Intra
MAD1L1 Q9Y6D9 TPM3 Homo sapiens P06753
Y2H Array
25416956
Intra
MAD1L1 Q9Y6D9 BAG5 Homo sapiens Q9UL15
Y2H Prey Pooling
25416956
Intra
MAD1L1 Q9Y6D9 PSMA1 Homo sapiens P25786
Y2H Array
25416956
Intra
MAD1L1 Q9Y6D9 PSMA1 Homo sapiens P25786
Validated Y2H
25416956
Intra
MAD1L1 Q9Y6D9 RNF8 Homo sapiens O76064
Y2H Array
31515488
Intra
MAD1L1 Q9Y6D9 CWF19L2 Homo sapiens Q2TBE0
Y2H Prey Pooling
25416956
Intra
MAD1L1 Q9Y6D9 TRIM29 Homo sapiens Q14134
Y2H Array
25416956
Intra
MAD1L1 Q9Y6D9 TRIM29 Homo sapiens Q14134
Y2H Pooling
16189514
Intra
MAD1L1 Q9Y6D9 TRIM29 Homo sapiens Q14134
Y2H Prey Pooling
25416956
Intra
MAD1L1 Q9Y6D9 ZSCAN32 Homo sapiens Q9NX65
Y2H Prey Pooling
25416956
Intra
MAD1L1 Q9Y6D9 ZSCAN32 Homo sapiens Q9NX65
Validated Y2H
25416956
Intra
MAD1L1 Q9Y6D9 ZSCAN32 Homo sapiens Q9NX65
Y2H Array
25416956
Intra
MAD1L1 Q9Y6D9 MAD2L1 Homo sapiens Q13257
Anti Bait CoIP
21772247
Intra
MAD1L1 Q9Y6D9 MAD2L1 Homo sapiens Q13257
NMR
18318601
Intra
MAD1L1 Q9Y6D9 MAD2L1 Homo sapiens Q13257
GMS
18318601
Intra
MAD1L1 Q9Y6D9 MAD2L1 Homo sapiens Q13257
Lumier
37398436
Intra
MAD1L1 Q9Y6D9 MAD2L1 Homo sapiens Q13257
IF
21772247
Intra
MAD1L1 Q9Y6D9 MAD2L1 Homo sapiens Q13257
BRET
37398436
Intra
MAD1L1 Q9Y6D9 MAD2L1 Homo sapiens Q13257
Anti Tag CoIP
22493223
Intra
MAD1L1 Q9Y6D9 MAD2L1 Homo sapiens Q13257
Y2H
21988832
Intra
MAD1L1 Q9Y6D9 MAD2L1 Homo sapiens Q13257
Y2H Array
31515488
Intra
MAD1L1 Q9Y6D9 MAD2L1 Homo sapiens Q13257
Anti Bait CoIP
24581499
Intra
MAD1L1 Q9Y6D9 MAD2L1 Homo sapiens Q13257
Anti Bait CoIP
26258632
Intra
MAD1L1 Q9Y6D9 ALOX5 Homo sapiens P09917
Y2H Prey Pooling
25416956
Intra
MAD1L1 Q9Y6D9 ALOX5 Homo sapiens P09917
Validated Y2H
25416956
Intra
MAD1L1 Q9Y6D9 TSHZ3 Homo sapiens Q63HK5
Y2H Prey Pooling
25416956
Intra
MAD1L1 Q9Y6D9 TSHZ3 Homo sapiens Q63HK5
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

MAD1L1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82704 MAD1L1 Antibody (YA2449) WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Retroperitoneum Carcinoma

Retroperitoneal Cancer

Malignant Neoplasm Of Retroperitoneum And Peritoneum

Retroperitoneal Neoplasms

Carcinoma Of Retroperitoneum

Carcinoma Of The Retroperitoneum

Malignant Neoplasm Of Retroperitoneum

Malignant Retroperitoneal Cancer

Malignant Tumor Of Peritoneum And Retroperitoneum

Neoplasm Of Retroperitoneum

Neoplasm Of The Retroperitoneum

Retroperitoneal Neoplasm

Tumor Of Retroperitoneum

Malignant Retroperitoneal Tumour

Primary Malignant Neoplasm Of Retroperitoneum

Retroperitoneum Cancer
Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07948 MAD1L1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MAD1L1 VGNC VGNC:74471
Bos taurus MAD1L1 VGNC VGNC:31130
Canis familiaris MAD1L1 VGNC VGNC:42914
Mus musculus MAD1L1 MGD MGI:1341857
Rattus norvegicus MAD1L1 RGD RGD:1596881
Felis catus MAD1L1 VGNC VGNC:68124