PRDX6 - peroxiredoxin 6 Gene

Homo sapiens

Also known as PRX; p29; AOP2; 1-Cys; NSGPx; aiPLA2; LPCAT-5; HEL-S-128m

Gene ID: 9588 | Gene type: protein coding

About PRDX6

Cytogenetic location: 1q25.1 Genomic coordinates (GRCh38): 1:173,477,335-173,488,815 (from NCBI)

This gene has 3 transcripts (splice variants), 184 orthologues and 4 paralogues. Ubiquitous expression in fat (RPKM 236.1), liver (RPKM 127.7) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional Enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008]

PRDX6 Products(1)

mRNA	Protein	Name
NM_004905.3	NP_004896.1	peroxiredoxin-6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 1-acylglycerophosphocholine O-acyltransferase activity	IDA IDA: Inferred from direct assay	26830860	GOA
enables calcium-independent phospholipase A2 activity	IMP IMP: Inferred from mutant phenotype	10893423	GOA
enables glutathione peroxidase activity	IMP IMP: Inferred from mutant phenotype	10893423	GOA
enables identical protein binding	IMP IMP: Inferred from mutant phenotype	9587003	GOA
enables phospholipase A2 activity	IDA IDA: Inferred from direct assay	26830860	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16186110	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	19725078	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular oxidant detoxification	IMP IMP: Inferred from mutant phenotype	10893423	GOA
involved in glycerophospholipid catabolic process	IMP IMP: Inferred from mutant phenotype	10893423	GOA
involved in positive regulation of mRNA splicing, via spliceosome	IGI IGI: Inferred from genetic interaction	16186110	GOA
involved in response to oxidative stress	IMP IMP: Inferred from mutant phenotype	10893423	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16186110	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16186110	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16186110	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRDX6 Protein Structure

AhpC-TSA

1-cysPrx_C

0
100
200
224 a.a.

Protein Preferred Names

Protein Names

peroxiredoxin-6

1-Cys PRX

PRDX6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PRDX6	P30041	ARFGAP3	Homo sapiens	Q9NP61	Y2H Array	32814053
Intra	PRDX6	P30041	ARFGAP3	Homo sapiens	Q9NP61	Y2H Pooling	32814053
Intra	PRDX6	P30041	ARFGAP3	Homo sapiens	Q9NP61	Validated Y2H	32814053
Intra	PRDX6	P30041	PCNA	Homo sapiens	P12004	Far-WB	20849852
Intra	PRDX6	P30041	PCNA	Homo sapiens	P12004	BiFC	26030842
Intra	PRDX6	P30041	PSMD8	Homo sapiens	P48556	Y2H Prey Pooling	32296183
Intra	PRDX6	P30041	PSMD8	Homo sapiens	P48556	Validated Y2H	32296183
Intra	PRDX6	P30041	PSMD8	Homo sapiens	P48556	Y2H Array	32296183
Intra	PRDX6	P30041	TERF1	Homo sapiens	P54274	Pull Down	21044950
Cross	PRDX6	P30041	P29991-PRO_0000308465	Dengue virus type 2	P29991-PRO_0000308465	Y2H	21911577

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRDX6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71145	PRDX6 Protein, Human (His)	P30041 (M1-P224)	≥95%

PRDX6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83409	Peroxiredoxin 6 Antibody (YA3154)	WB, IP	Human

Related Diseases

Diseases

Alias

Gnathomiasis

Gnathostomiasis	Infectious Disease By Gnathostoma
Gnathostomosis	Wandering Swelling

Fuchs' Endothelial Dystrophy

Fuchs Endothelial Corneal Dystrophy	Fuchs Endothelial Dystrophy
Fuchs Dystrophy	Fced
Fuchs' Corneal Dystrophy	Fuchs' Endothelial Corneal Dystrophy
Fuchs Atrophy	Fuchs Corneal Dystrophy
Endoepithelial Corneal Dystrophy	Fecd
Late Hereditary Endothelial Dystrophy	Corneal Dystrophy, Fuchs Endothelial
Dystrophy, Corneal, Fuchs Endothelial	Corneal Dystrophy, Fuchs' Endothelial, 1

Diabetic Cataract

Cataract - Diabetic

Small Intestine Leiomyosarcoma

Leiomyosarcoma Of The Small Bowel	Smooth Muscle Connective Tissue Tumor
Leiomyosarcoma Of Small Intestine

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115062	MJ33 lithium salt	Inhibitor	≥99.0%	Unkown
HY-129944A	MJ33-OH lithium	Inhibitor	≥90.0%	Unkown
HY-129944	MJ33-OH	Inhibitor	/	Unkown
HY-RS11079	PRDX6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PRDX6	VGNC	VGNC:76267
Felis catus	PRDX6	VGNC	VGNC:107925
Bos taurus	PRDX6	VGNC	VGNC:33304
Mus musculus	PRDX6	MGD	MGI:894320
Canis familiaris	PRDX6	VGNC	VGNC:44953
Rattus norvegicus	PRDX6	RGD	RGD:71005
Others	PRDX6	NCBI

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