2. Gene
  3. ASB6 - ankyrin repeat and SOCS box containing 6 Gene

ASB6 - ankyrin repeat and SOCS box containing 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 140459 | Gene type: protein coding

About ASB6

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:129,634,605-129,642,151 (from NCBI)

This gene has 3 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in testis (RPKM 8.1), bone marrow (RPKM 7.8) and 25 other tissues.

Summary

The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contain a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jan 2011]

ASB6 Products(3)

mRNA Protein Name
NM_001202403.2 NP_001189332.1 ankyrin repeat and SOCS box protein 6 isoform 3
NM_017873.4 NP_060343.1 ankyrin repeat and SOCS box protein 6 isoform 1
NM_177999.3 NP_821066.1 ankyrin repeat and SOCS box protein 6 isoform 2
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16325183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASB6 Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (43 - 133)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (139 - 205)

SOCS_box

SOCS_box: SOCS box (372 - 411)

  • 0
  • 100
  • 200
  • 300
  • 421 a.a.
Protein Preferred Names Protein Names

ankyrin repeat and SOCS box protein 6

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01071 ASB6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ASB6 RGD RGD:1308445
Canis familiaris ASB6 VGNC VGNC:38166
Felis catus ASB6 VGNC VGNC:59962
Bos taurus ASB6 VGNC VGNC:26199
Mus musculus ASB6 MGD MGI:1919573
Macaca mulatta ASB6 VGNC VGNC:69850