ASB6 - ankyrin repeat and SOCS box containing 6 Gene

Homo sapiens

Gene ID: 140459 | Gene type: protein coding

About ASB6

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:129,634,605-129,642,151 (from NCBI)

This gene has 3 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in testis (RPKM 8.1), bone marrow (RPKM 7.8) and 25 other tissues.

Summary

The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four Other protein families, contain a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jan 2011]

ASB6 Products(3)

mRNA	Protein	Name
NM_001202403.2	NP_001189332.1	ankyrin repeat and SOCS box protein 6 isoform 3
NM_017873.4	NP_060343.1	ankyrin repeat and SOCS box protein 6 isoform 1
NM_177999.3	NP_821066.1	ankyrin repeat and SOCS box protein 6 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16325183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASB6 Protein Structure

Ank_2

SOCS_box

0
100
200
300
421 a.a.

Protein Preferred Names

Protein Names

ankyrin repeat and SOCS box protein 6

ASB6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ASB6	Q9NWX5	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	25416956
Intra	ASB6	Q9NWX5	CUL5	Homo sapiens	Q93034	Anti Tag CoIP	21145461
Intra	ASB6	Q9NWX5	CUL5	Homo sapiens	Q93034	TAP	21145461
Intra	ASB6	Q9NWX5	CUL5	Homo sapiens	Q93034	Anti Tag CoIP	33961781
Intra	ASB6	Q9NWX5	CUL5	Homo sapiens	Q93034	Anti Tag CoIP	16325183
Intra	ASB6	Q9NWX5	CUL5	Homo sapiens	Q93034	Anti Tag CoIP	28514442
Intra	ASB6	Q9NWX5	ZBTB42	Homo sapiens	B2RXF5	Y2H Array	32296183
Intra	ASB6	Q9NWX5	ZBTB42	Homo sapiens	B2RXF5	Y2H Prey Pooling	32296183
Intra	ASB6	Q9NWX5	SH2B2	Homo sapiens	O14492-2	Y2H Prey Pooling	32296183
Intra	ASB6	Q9NWX5	SH2B2	Homo sapiens	O14492-2	Y2H Array	32296183
Intra	ASB6	Q9NWX5	RNF41	Homo sapiens	Q9H4P4	Anti Tag CoIP	28514442
Intra	ASB6	Q9NWX5	RNF41	Homo sapiens	Q9H4P4	Y2H Array	32296183
Intra	ASB6	Q9NWX5	RNF41	Homo sapiens	Q9H4P4	Validated Y2H	25416956
Intra	ASB6	Q9NWX5	RNF41	Homo sapiens	Q9H4P4	Anti Tag CoIP	33961781
Intra	ASB6	Q9NWX5	RNF41	Homo sapiens	Q9H4P4	Y2H Prey Pooling	25416956
Intra	ASB6	Q9NWX5	RNF41	Homo sapiens	Q9H4P4	Y2H Prey Pooling	32296183
Intra	ASB6	Q9NWX5	L3MBTL3	Homo sapiens	Q96JM7	Y2H Prey Pooling	25416956
Intra	ASB6	Q9NWX5	L3MBTL3	Homo sapiens	Q96JM7	Y2H Array	25416956
Intra	ASB6	Q9NWX5	POLR2A	Homo sapiens	P24928	Y2H Prey Pooling	32296183
Intra	ASB6	Q9NWX5	POLR2A	Homo sapiens	P24928	Anti Tag CoIP	33961781
Intra	ASB6	Q9NWX5	POLR2A	Homo sapiens	P24928	Y2H Array	32296183
Intra	ASB6	Q9NWX5	POLR2A	Homo sapiens	P24928	Anti Tag CoIP	28514442
Intra	ASB6	Q9NWX5	RNF7	Homo sapiens	Q9UBF6	Anti Tag CoIP	16325183
Intra	ASB6	Q9NWX5	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	ASB6	Q9NWX5	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01071	ASB6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ASB6	RGD	RGD:1308445
Canis familiaris	ASB6	VGNC	VGNC:38166
Felis catus	ASB6	VGNC	VGNC:59962
Bos taurus	ASB6	VGNC	VGNC:26199
Mus musculus	ASB6	MGD	MGI:1919573
Macaca mulatta	ASB6	VGNC	VGNC:69850

Name
Email *

	Sorry, but the email address you supplied was invalid.