SNCAIP - synuclein alpha interacting protein Gene

Homo sapiens

Also known as Sph1; SYPH1

Gene ID: 9627 | Gene type: protein coding

About SNCAIP

Cytogenetic location: 5q23.2 Genomic coordinates (GRCh38): 5:122,311,353-122,464,219 (from NCBI)

This gene has 19 transcripts (splice variants), 191 orthologues and is associated with 1 phenotype. Biased expression in ovary (RPKM 8.3), endometrium (RPKM 6.2) and 11 other tissues.

Summary

This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

SNCAIP Products(8)

mRNA	Protein	Name
NM_001242935.3	NP_001229864.1	synphilin-1 isoform 1A
NM_001308100.2	NP_001295029.1	synphilin-1 isoform 2
NM_001308105.1	NP_001295034.1	synphilin-1 isoform B
NM_001308106.1	NP_001295035.1	synphilin-1 isoform D
NM_001308107.2	NP_001295036.1	synphilin-1 isoform E
NM_001308108.1	NP_001295037.1	synphilin-1 isoform F
NM_001308109.2	NP_001295038.1	synphilin-1 isoform G
NM_005460.4	NP_005451.2	synphilin-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	19762560	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10319874	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	15728840	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell death	IDA IDA: Inferred from direct assay	16595633	GOA
acts upstream of or within dopamine metabolic process	IDA IDA: Inferred from direct assay	14506261	GOA
involved in regulation of inclusion body assembly	IDA IDA: Inferred from direct assay	15603737	GOA
acts upstream of or within regulation of neurotransmitter secretion	IDA IDA: Inferred from direct assay	14506261	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	14506261	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNCAIP Protein Structure

Ank_2

0
200
400
600
800
919 a.a.

Protein Preferred Names

Protein Names

synphilin-1

SNCAIP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SNCAIP	Q9Y6H5	SNCA	Homo sapiens	P37840	Y2H	12044636
Intra	SNCAIP	Q9Y6H5	SNCA	Homo sapiens	P37840	Pull Down	19762560
Intra	SNCAIP	Q9Y6H5	SNCA	Homo sapiens	P37840	Confocal	19762560
Intra	SNCAIP	Q9Y6H5	SNCA	Homo sapiens	P37840	Y2H	10319874
Intra	SNCAIP	Q9Y6H5	SNCA	Homo sapiens	P37840	Confocal	10319874
Intra	SNCAIP	Q9Y6H5	SNCA	Homo sapiens	P37840	FCS	19762560
Intra	SNCAIP	Q9Y6H5	SNCAIP	Homo sapiens	Q9Y6H5	Pull Down	19762560
Intra	SNCAIP	Q9Y6H5	SNCAIP	Homo sapiens	Q9Y6H5	Crosslink	19762560
Intra	SNCAIP	Q9Y6H5	SNCA	Homo sapiens	P37840	NMR	19762560

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Parkinson Disease 3, Autosomal Dominant

PARK3	Parkinson Disease 3
Parkinson Disease 3, Autosomal Dominant Lewy Body	Parkinson'S Disease 3
Autosomal Dominant Lewy Body Parkinson Disease 3	Autosomal Dominant Parkinson Disease 3
Parkinson Disease Type 3	Autosomal Dominant Parkinson Disease
Parkinson Disease, Autosomal Dominant	Parkinson Disease, Familial, Type 1

Dementia

Dementias	Presenile Dementia
Alzheimer Type Dementia	Alzheimer Sclerosis
Alzheimer Disease Dementia	Alzheimer Dementia
Primary Degenerative Alzheimer Type Dementia	End Stage Alzheimer'S Dementia
Alzheimer'S Type Atypical Dementia	Alzheimer Type Presenile Dementia
Early Onset Alzheimer Dementia	Dementia In Alzheimer Disease Type 2
Dementia In Alzheimer Disease With Early Onset	Early Onset Alzheimer Type Dementia, Uncomplicated
Primary Degenerative Alzheimer Type Dementia, Early Onset	Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated
Alzheimer Disease Dementia With Early Onset	Presenile Sclerosis
Presenile Brain Sclerosis	Presenile Alzheimer Brain Sclerosis
Late Onset Alzheimer Dementia	Dementia In Alzheimer Disease Type 1
Dementia In Alzheimer Disease With Late Onset	Primary Degenerative Alzheimer Type Dementia, Late Onset
Sdat - [Senile Dementia, Alzheimer Type]	Alzheimer Disease Dementia With Late Onset
Late Onset Alzheimer Brain Sclerosis	Senile Alzheimer Brain Disease
Senile Alzheimer Brain Sclerosis	Senile Primary Degenerative Alzheimer Type Dementia
Senile Dementia Of The Alzheimer Type	Arteriosclerotic Dementia
Strategic-Infarct Dementia	Post Stroke Dementia
Vascular Cognitive Impairment	Vascular Dementia
Dementia Of The Lewy Body Type	Dementia With Lewy Bodies
Sdlt - [Senile Dementia Of The Lewy Body Type]	Senile Dementia Of The Lewy Body Type
Alcohol-Related Dementia	Alcoholic Dementia Nos
Alcohol-Induced Dementia	Alcoholic Brain Syndrome
Chronic Alcoholic Brain Syndrome	Alcohol Dementia
Late Onset Alcoholic Psychosis	Residual And Late-Onset Alcohol-Induced Psychotic Disorder
Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder	Late-Onset Psychoactive Substance-Induced Psychotic Disorder
Inhalant Dementia	Volatile Solvents Dementia
Dementia In Paralysis Agitans	Pdd - [Parkinson Disease Dementia]
Dementia Syndrome Of Parkinson Disease	Dementia In Parkinson Disease
Parkinson Related Dementia	Dementia In Huntington Chorea
Hiv - [Human Immunodeficiency Virus] Dementia	Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex
Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex	Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex
Aids Related Dementia	Dementia Due To Niacin Deficiency

Dementia, Lewy Body

Lewy Body Dementia	Lewy Body Disease
Diffuse Lewy Body Disease	Dementia With Lewy Bodies
DLB	Autosomal Dominant Diffuse Lewy Body Disease
Cortical Lewy Body Disease	Dementia, Lewy Body, Susceptibility To
Lewy Body Dementia, Susceptibility To	Senile Dementia Of The Lewy Body Type
Dementia Of The Lewy Body Type	Lbd
Diffuse Lewy Body Disease With Gaze Palsy	Dysphasic Dementia Hereditary
Lewy Body Type Senile Dementia	Lewy Body Variant Of Alzheimer Disease
Lewy Bodies	Lewy Body
Dlbd - [Diffuse Lewy Body Disease]	Clbd - [Cortical Lewy Body Disease]

Juvenile-Onset Parkinson'S Disease

Juvenile-Onset Parkinson Disease

Movement Disease

Movement Disorders

Movement Disorder

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13485	SNCAIP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SNCAIP	VGNC	VGNC:46597
Macaca mulatta	SNCAIP	VGNC	VGNC:77669
Felis catus	SNCAIP	VGNC	VGNC:65525
Bos taurus	SNCAIP	VGNC	VGNC:35060
Rattus norvegicus	SNCAIP	RGD	RGD:1309283
Mus musculus	SNCAIP	MGD	MGI:1915097

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