KDM4A - lysine demethylase 4A Gene

Homo sapiens

Also known as JMJD2; JHDM3A; JMJD2A; TDRD14A

Gene ID: 9682 | Gene type: protein coding

About KDM4A

Cytogenetic location: 1p34.2-p34.1 Genomic coordinates (GRCh38): 1:43,650,149-43,705,518 (from NCBI)

This gene has 5 transcripts (splice variants), 137 orthologues and 10 paralogues. Ubiquitous expression in duodenum (RPKM 11.5), thyroid (RPKM 10.1) and 25 other tissues.

Summary

This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009]

KDM4A Products(1)

mRNA	Protein	Name
NM_014663.3	NP_055478.2	lysine-specific demethylase 4A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone H3K36 demethylase activity	IDA IDA: Inferred from direct assay	16024779	GOA
enables histone H3K9me2/H3K9me3 demethylase activity	IMP IMP: Inferred from mutant phenotype	21914792	GOA
enables methylated histone binding	IDA IDA: Inferred from direct assay	22373579	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16415788	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	22373579	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	27214403	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16024779	GOA
involved in negative regulation of autophagy	IMP IMP: Inferred from mutant phenotype	25660547	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25660547	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	16024779	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	21914792	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KDM4A Protein Structure

JmjN

JmjC

PHD_2

zf-HC5HC2H_2

0
200
400
600
800
1000
1064 a.a.

Protein Preferred Names

Protein Names

lysine-specific demethylase 4A

[histone H3]-trimethyl-L-lysine(36) demethylase 4A

Related Diseases

Diseases

Alias

Primary Hyperoxaluria

Hyperoxaluria	Hyperoxaluria, Primary
Oxalosis	Primary Oxalosis
Congenital Oxaluria	D-Glycerate Dehydrogenase Deficiency
Glyceric Aciduria	Glycolic Aciduria
Hepatic Agt Deficiency	Oxaluria, Primary
Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency	Primary Oxaluria
Hyperoxaluria Primary	Primary Hyperoxaluria Type 2
Primary Hyperoxaluria, Type I

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-104048	QC6352	Inhibitor	99.48%	Unkown
HY-100760	Toxoflavin	Inhibitor	99.92%	Unkown
HY-107573	KDM2/7-IN-1	Inhibitor	99.00%	Unkown
HY-110154	NSC636819		98.9%	Unkown
HY-128343	KDM4-IN-2	Inhibitor	98.29%	Unkown
HY-100760S	Toxoflavin-13C4	Inhibitor	/	Unkown
HY-150619	KDM4-IN-4	Inhibitor	/	Unkown
HY-RS07213	KDM4A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	KDM4A	VGNC	VGNC:30527
Rattus norvegicus	KDM4A	RGD	RGD:1306378
Macaca mulatta	KDM4A	VGNC	VGNC:99987
Felis catus	KDM4A	VGNC	VGNC:80248
Mus musculus	KDM4A	MGD	MGI:2446210
Canis familiaris	KDM4A	VGNC	VGNC:42324
Others	KDM4A	NCBI

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