CLINT1 - clathrin interactor 1 Gene

Homo sapiens

Also known as ENTH; EPN4; EPNR; CLINT

Gene ID: 9685 | Gene type: protein coding

About CLINT1

Cytogenetic location: 5q33.3 Genomic coordinates (GRCh38): 5:157,785,747-157,859,145 (from NCBI)

This gene has 10 transcripts (splice variants), 281 orthologues and 5 paralogues. Ubiquitous expression in bone marrow (RPKM 39.0), gall bladder (RPKM 37.4) and 25 other tissues.

Summary

This gene encodes a protein with similarity to the epsin family of endocytic adapter proteins. The encoded protein interacts with clathrin, the adapter protein AP-1 and phosphoinositides. This protein may be involved in the formation of clathrin coated vesicles and trafficking between the trans-Golgi network and endosomes. Mutations in this gene are associated with a susceptibility to schizophrenia and psychotic disorders. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

CLINT1 Products(3)

mRNA	Protein	Name
NM_001195555.2	NP_001182484.1	clathrin interactor 1 isoform 1
NM_001195556.2	NP_001182485.1	clathrin interactor 1 isoform 3
NM_014666.4	NP_055481.1	clathrin interactor 1 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables clathrin binding	IPI IPI: Inferred from physical interaction	12429846	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12429846	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	10942595	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLINT1 Protein Structure

ENTH

0
100
200
300
400
500
625 a.a.

Protein Preferred Names

Protein Names

clathrin interactor 1

clathrin interacting protein localized in the trans-Golgi region

CLINT1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	CLINT1	Q14677	Ap1g1	Mus musculus	P22892	Pull Down	14675752
Intra	CLINT1	Q14677	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	CLINT1	Q14677	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	CLINT1	Q14677	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	CLINT1	Q14677	BMP2K	Homo sapiens	Q9NSY1	Anti Tag CoIP	33961781
Intra	CLINT1	Q14677	GDPD5	Homo sapiens	Q8WTR4-3	Y2H Prey Pooling	26871637
Intra	CLINT1	Q14677	GDPD5	Homo sapiens	Q8WTR4-3	Validated Y2H	26871637
Intra	CLINT1	Q14677	GDPD5	Homo sapiens	Q8WTR4-3	Y2H Array	26871637
Intra	CLINT1	Q14677	MAP1LC3B	Homo sapiens	Q9GZQ8	Pull Down	20562859
Intra	CLINT1	Q14677	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	CLINT1	Q14677	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	CLINT1	Q14677	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	CLINT1	Q14677	GABARAPL1	Homo sapiens	Q9H0R8	Pull Down	20562859
Cross	CLINT1	Q14677	Vti1b	Mus musculus	O88384	ITC	18033301
Cross	CLINT1	Q14677	Vti1b	Mus musculus	O88384	X-Ray Diffraction	18033301
Cross	CLINT1	Q14677	Vti1b	Mus musculus	O88384	Pull Down	18033301
Cross	CLINT1	Q14677	P29991-PRO_0000037943	Dengue virus type 2	P29991-PRO_0000037943	SLC	35452674

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Erythrocytosis, Familial, 7

ECYT7	Erythrocytosis 7
Familial Erythrocytosis 7	Erythrocytosis, Alpha-Globin Type
Polycythemia, Alpha-Globin Type	Alpha-Globin Type Erythrocytosis
Alpha-Globin Type Polycythemia

Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive

Charcot-Marie-Tooth Disease Type 4	Charcot-Marie-Tooth Disease Type 4e
Hereditary Motor And Sensory Neuropathy	Cmt4e
CHN1	Hypomyelinating Neuropathy, Congenital, 1
Charcot-Marie-Tooth Neuropathy Type 4e	Neuropathy, Congenital Hypomyelinating, 1
Ar-Cmt1	Autosomal Recessive Demyelinating Charcot-Marie-Tooth
Cmt4	Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive
Hypomyelination, Severe Congenital	Charcot-Marie-Tooth Disease, Type 4e
Charcot-Marie-Tooth Neuropathy, Type 4e	Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy
Autosomal Recessive Congenital Hypomyelinating Neuropathy	Congenital Amyelinating Neuropathy
Congenital Hypomyelinating Neuropathy Autosomal Recessive	Neuropathy, Congenital Hypomyelinating Or Amyelinating
Severe Congenital Hypomyelination	Hereditary Sensory Motor Neuropathy
Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive	Neuropathy, Hypomyelinating, Congenital, Type 1
Neuropathy, Motor And Sensory, Hereditary	Congenital Hypomyelinating Neuropathy
Hereditary Motor And Sensory Neuropathies	Hereditary Sensorimotor Neuropathy
Hmsn - [Hereditary Motor And Sensory Neuropathy]	Hsmn - [Hereditary Sensory And Motor Neuropathy]
Hereditary Motor And Sensory Neuropathy, Types I-Iv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02809	CLINT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CLINT1	RGD	RGD:1303328
Felis catus	CLINT1	VGNC	VGNC:97382
Mus musculus	CLINT1	MGD	MGI:2144243
Canis familiaris	CLINT1	VGNC	VGNC:39342
Bos taurus	CLINT1	VGNC	VGNC:27443
Macaca mulatta	CLINT1	VGNC	VGNC:84289

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