2. Gene
  3. CD72 - CD72 molecule Gene

CD72 - CD72 molecule Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LYB2; CD72b

Gene ID: 971 | Gene type: protein coding

About CD72

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:35,609,982-35,646,857 (from NCBI)

This gene has 10 transcripts (splice variants) and 126 orthologues. Biased expression in lymph node (RPKM 32.2), spleen (RPKM 30.4) and 4 other tissues.

Summary

Predicted to enable signaling receptor binding activity. Predicted to be involved in cell adhesion. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

CD72 Products(1)

mRNA Protein Name
NM_001782.3 NP_001773.1 B-cell differentiation antigen CD72
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
1711157 GOA
enables transmembrane signaling receptor activity IDA
IDA: Inferred from direct assay
27810925 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of B cell receptor signaling pathway IDA
IDA: Inferred from direct assay
1711157 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
1711157 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD72 Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (251 - 352)

  • 0
  • 100
  • 200
  • 300
  • 359 a.a.
Protein Preferred Names Protein Names

B-cell differentiation antigen CD72

CD72 antigen

CD72 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CD72 P21854 LSMEM2 Homo sapiens Q8N112
Y2H Prey Pooling
32296183
Intra
CD72 P21854 LSMEM2 Homo sapiens Q8N112
Validated Y2H
32296183
Intra
CD72 P21854 LSMEM2 Homo sapiens Q8N112
Y2H Array
32296183
Intra
CD72 P21854 LRRC25 Homo sapiens Q8N386
Y2H Array
32296183
Intra
CD72 P21854 LRRC25 Homo sapiens Q8N386
Validated Y2H
32296183
Intra
CD72 P21854 LRRC25 Homo sapiens Q8N386
Y2H Prey Pooling
32296183
Intra
CD72 P21854 MS4A3 Homo sapiens Q96HJ5
Y2H Prey Pooling
32296183
Intra
CD72 P21854 MS4A3 Homo sapiens Q96HJ5
Validated Y2H
32296183
Intra
CD72 P21854 MS4A3 Homo sapiens Q96HJ5
Y2H Array
32296183
Intra
CD72 P21854 NRG1 Homo sapiens Q02297-10
Y2H Prey Pooling
32296183
Intra
CD72 P21854 NRG1 Homo sapiens Q02297-10
Validated Y2H
32296183
Intra
CD72 P21854 NRG1 Homo sapiens Q02297-10
Y2H Array
32296183
Intra
CD72 P21854 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
CD72 P21854 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra
CD72 P21854 SPACA1 Homo sapiens Q9HBV2
Y2H Array
32296183
Intra
CD72 P21854 SPACA1 Homo sapiens Q9HBV2
Validated Y2H
32296183
Intra
CD72 P21854 SPACA1 Homo sapiens Q9HBV2
Y2H Prey Pooling
32296183
Intra
CD72 P21854 CGRRF1 Homo sapiens Q99675
Y2H Array
32296183
Intra
CD72 P21854 CGRRF1 Homo sapiens Q99675
Y2H Prey Pooling
32296183
Intra
CD72 P21854 CGRRF1 Homo sapiens Q99675
Validated Y2H
32296183
Intra
CD72 P21854 ATP6AP2 Homo sapiens O75787
Y2H Prey Pooling
32296183
Intra
CD72 P21854 ATP6AP2 Homo sapiens O75787
Y2H Array
32296183
Intra
CD72 P21854 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
Intra
CD72 P21854 LHFPL5 Homo sapiens Q8TAF8
Validated Y2H
32296183
Intra
CD72 P21854 LHFPL5 Homo sapiens Q8TAF8
Y2H Array
32296183
Intra
CD72 P21854 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
CD72 P21854 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
CD72 P21854 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
CD72 P21854 BIK Homo sapiens Q13323
Y2H Array
32296183
Intra
CD72 P21854 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
Intra
CD72 P21854 BIK Homo sapiens Q13323
Validated Y2H
32296183
Intra
CD72 P21854 GRAMD1C Homo sapiens Q8IYS0
Validated Y2H
32296183
Intra
CD72 P21854 GRAMD1C Homo sapiens Q8IYS0
Y2H Array
32296183
Intra
CD72 P21854 GRAMD1C Homo sapiens Q8IYS0
Y2H Prey Pooling
32296183
Intra
CD72 P21854 MS4A7 Homo sapiens Q9GZW8
Y2H Prey Pooling
32296183
Intra
CD72 P21854 MS4A7 Homo sapiens Q9GZW8
Validated Y2H
32296183
Intra
CD72 P21854 MS4A7 Homo sapiens Q9GZW8
Y2H Array
32296183
Intra
CD72 P21854 CLDN7 Homo sapiens O95471
Y2H Array
32296183
Intra
CD72 P21854 CLDN7 Homo sapiens O95471
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD72 Proteins

Cat. No. Product Name Accession Purity
HY-P72711 CD72 Protein, Human (Trx, His) P21854 (R117-C226) ≥95%

Related Diseases

Diseases Alias
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02265 CD72 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CD72 VGNC VGNC:38971
Bos taurus CD72 VGNC VGNC:27045
Macaca mulatta CD72 VGNC VGNC:70778
Rattus norvegicus CD72 RGD RGD:1309757
Mus musculus CD72 MGD MGI:88345
Felis catus CD72 VGNC VGNC:60637
Others CD72 NCBI