IP6K1 - inositol hexakisphosphate kinase 1 Gene

Homo sapiens

Also known as PiUS; IHPK1

Gene ID: 9807 | Gene type: protein coding

About IP6K1

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,724,294-49,786,542 (from NCBI)

This gene has 9 transcripts (splice variants), 218 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 17.4), testis (RPKM 16.8) and 25 other tissues.

Summary

This gene encodes a member of the inositol phosphokinase family. The encoded protein may be responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2011]

IP6K1 Products(3)

mRNA	Protein	Name
NM_001006115.3	NP_001006115.1	inositol hexakisphosphate kinase 1 isoform 2
NM_001242829.2	NP_001229758.1	inositol hexakisphosphate kinase 1 isoform 1
NM_153273.4	NP_695005.1	inositol hexakisphosphate kinase 1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables inositol hexakisphosphate kinase activity	IDA IDA: Inferred from direct assay	10574768	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in phosphatidylinositol phosphate biosynthetic process	IDA IDA: Inferred from direct assay	10574768	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IP6K1 Protein Structure

IPK

0
100
200
300
400
441 a.a.

Protein Preferred Names

Protein Names

inositol hexakisphosphate kinase 1

ATP:1D-myo-inositol-hexakisphosphate phosphotransferase

IP6K1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IP6K1	Q92551	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Prey Pooling	32296183
Intra	IP6K1	Q92551	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	32296183
Intra	IP6K1	Q92551	UBE4A	Homo sapiens	Q14139	Y2H Array	32296183
Intra	IP6K1	Q92551	UBE4A	Homo sapiens	Q14139	Y2H Prey Pooling	32296183
Intra	IP6K1	Q92551	RPL11	Homo sapiens	P62913-2	Y2H Prey Pooling	32296183
Intra	IP6K1	Q92551	RPL11	Homo sapiens	P62913-2	Y2H Array	32296183
Intra	IP6K1	Q92551	VIM	Homo sapiens	P08670	Y2H Array	32296183
Intra	IP6K1	Q92551	VIM	Homo sapiens	P08670	Y2H Prey Pooling	32296183
Intra	IP6K1	Q92551	EXOSC7	Homo sapiens	Q15024	Y2H Array	32296183
Intra	IP6K1	Q92551	EXOSC7	Homo sapiens	Q15024	Y2H Pooling	16189514
Intra	IP6K1	Q92551	EXOSC7	Homo sapiens	Q15024	Y2H Prey Pooling	32296183
Intra	IP6K1	Q92551	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	IP6K1	Q92551	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	IP6K1	Q92551	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IP6K1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77427	IP6K1/IHPK1 Protein, Human (sf9, His-GST)	Q92551 (M1-Q441)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150607	UNC7467		98.07%	Unkown
HY-110079	TNP	Inhibitor	99.29%	Unkown
HY-153530	LI-2242		98.95%	Unkown
HY-122706A	IP6K2-IN-2	Inhibitor	/	Unkown
HY-RS06861	IP6K1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	IP6K1	VGNC	VGNC:30237
Rattus norvegicus	IP6K1	RGD	RGD:71025
Felis catus	IP6K1	VGNC	VGNC:62951
Macaca mulatta	IP6K1	VGNC	VGNC:73621
Canis familiaris	IP6K1	VGNC	VGNC:42061
Mus musculus	IP6K1	MGD	MGI:1351633
Others	IP6K1	NCBI

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