ARHGEF7 - Rho guanine nucleotide exchange factor 7 Gene

Homo sapiens

Also known as P50; P85; PAK3; PIXB; COOL1; P50BP; COOL-1; P85SPR; BETA-PIX; P85COOL1; Nbla10314

Gene ID: 8874 | Gene type: protein coding

About ARHGEF7

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:111,114,619-111,305,734 (from NCBI)

This gene has 21 transcripts (splice variants), 350 orthologues and 22 paralogues. Ubiquitous expression in brain (RPKM 14.7), fat (RPKM 11.2) and 25 other tissues.

Summary

This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Mar 2016]

ARHGEF7 Products(27)

mRNA	Protein	Name
NM_001113511.2	NP_001106983.1	rho guanine nucleotide exchange factor 7 isoform c
NM_001113512.2	NP_001106984.1	rho guanine nucleotide exchange factor 7 isoform d
NM_001113513.2	NP_001106985.1	rho guanine nucleotide exchange factor 7 isoform a
NM_001320851.2	NP_001307780.1	rho guanine nucleotide exchange factor 7 isoform a
NM_001320852.1	NP_001307781.1	rho guanine nucleotide exchange factor 7 isoform e
NM_001320853.2	NP_001307782.1	rho guanine nucleotide exchange factor 7 isoform f
NM_001320854.2	NP_001307783.1	rho guanine nucleotide exchange factor 7 isoform g
NM_001330597.2	NP_001317526.1	rho guanine nucleotide exchange factor 7 isoform h
NM_001330598.2	NP_001317527.1	rho guanine nucleotide exchange factor 7 isoform h
NM_001354046.2	NP_001340975.1	rho guanine nucleotide exchange factor 7 isoform i
NM_001354047.1	NP_001340976.1	rho guanine nucleotide exchange factor 7 isoform j
NM_001354048.1	NP_001340977.1	rho guanine nucleotide exchange factor 7 isoform k
NM_001354049.2	NP_001340978.1	rho guanine nucleotide exchange factor 7 isoform k
NM_001354050.2	NP_001340979.1	rho guanine nucleotide exchange factor 7 isoform k
NM_001354051.2	NP_001340980.1	rho guanine nucleotide exchange factor 7 isoform k
NM_001354052.2	NP_001340981.1	rho guanine nucleotide exchange factor 7 isoform a
NM_001354053.2	NP_001340982.1	rho guanine nucleotide exchange factor 7 isoform a
NM_001354054.2	NP_001340983.1	rho guanine nucleotide exchange factor 7 isoform l
NM_001354055.2	NP_001340984.1	rho guanine nucleotide exchange factor 7 isoform m
NM_001354056.1	NP_001340985.1	rho guanine nucleotide exchange factor 7 isoform h
NM_001354057.2	NP_001340986.1	rho guanine nucleotide exchange factor 7 isoform h
NM_001354058.2	NP_001340987.1	rho guanine nucleotide exchange factor 7 isoform h
NM_001354059.2	NP_001340988.1	rho guanine nucleotide exchange factor 7 isoform h
NM_001354060.2	NP_001340989.1	rho guanine nucleotide exchange factor 7 isoform h
NM_001354061.2	NP_001340990.1	rho guanine nucleotide exchange factor 7 isoform n
NM_003899.5	NP_003890.1	rho guanine nucleotide exchange factor 7 isoform a
NM_145735.3	NP_663788.1	rho guanine nucleotide exchange factor 7 isoform b

ARHGEF7 Protein Structure

SH3_2

RhoGEF

0
200
400
600
803 a.a.

Protein Preferred Names

Protein Names

rho guanine nucleotide exchange factor 7

PAK-interacting exchange factor beta

ARHGEF7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ARHGEF7	Q14155	PAK2	Homo sapiens	Q13177	Phage Display	16374509
Intra	ARHGEF7	Q14155	PAK2	Homo sapiens	Q13177	Anti Tag CoIP	35271311
Intra	ARHGEF7	Q14155	PAK2	Homo sapiens	Q13177	Filter Binding	16374509
Intra	ARHGEF7	Q14155	PAK2	Homo sapiens	Q13177	Anti Tag CoIP	33961781
Intra	ARHGEF7	Q14155	PAK2	Homo sapiens	Q13177	Competition Binding	16787945
Intra	ARHGEF7	Q14155	GIT2	Homo sapiens	Q14161	Anti Tag CoIP	33961781
Intra	ARHGEF7	Q14155	GIT2	Homo sapiens	Q14161	Anti Tag CoIP	35271311
Intra	ARHGEF7	Q14155	GIT2	Homo sapiens	Q14161	Anti Bait CoIP	16628223
Intra	ARHGEF7	Q14155	PAK1	Homo sapiens	Q13153	Anti Tag CoIP	33961781
Intra	ARHGEF7	Q14155	PAK1	Homo sapiens	Q13153	Y2H Pooling	20936779
Intra	ARHGEF7	Q14155	PAK1	Homo sapiens	Q13153	Lumier	29997244
Intra	ARHGEF7	Q14155	PAK1	Homo sapiens	Q13153	Anti Tag CoIP	35271311
Intra	ARHGEF7	Q14155	PAK1	Homo sapiens	Q13153	NMR	16101281
Intra	ARHGEF7	Q14155	SHANK3	Homo sapiens	Q9BYB0	Y2H Pooling	21653829
Intra	ARHGEF7	Q14155	SHANK3	Homo sapiens	Q9BYB0	Anti Tag CoIP	21653829
Intra	ARHGEF7	Q14155	SRGAP1	Homo sapiens	Q7Z6B7	Anti Tag CoIP	25150978
Intra	ARHGEF7	Q14155	CDC42	Homo sapiens	P60953-2	Pull Down	25150978
Intra	ARHGEF7	Q14155	CDC42	Homo sapiens	P60953-2	Anti Tag CoIP	25150978
Intra	ARHGEF7	Q14155	PPP2R1A	Homo sapiens	P30153	Anti Tag CoIP	25150978
Intra	ARHGEF7	Q14155	SCRIB	Homo sapiens	Q14160	Phage Display	24550280
Intra	ARHGEF7	Q14155	SCRIB	Homo sapiens	Q14160	Pull Down	19555689
Intra	ARHGEF7	Q14155	SCRIB	Homo sapiens	Q14160	Pull Down	15975580
Intra	ARHGEF7	Q14155	SCRIB	Homo sapiens	Q14160	Anti Tag CoIP	33961781
Intra	ARHGEF7	Q14155	SCRIB	Homo sapiens	Q14160	Anti Tag CoIP	35271311
Intra	ARHGEF7	Q14155	SCRIB	Homo sapiens	Q14160	Anti Bait CoIP	21132015
Intra	ARHGEF7	Q14155	SCRIB	Homo sapiens	Q14160	Anti Tag CoIP	15975580
Intra	ARHGEF7	Q14155	RAC1	Homo sapiens	P63000	Pull Down	16492808
Intra	ARHGEF7	Q14155	GIT1	Homo sapiens	Q9Y2X7	Anti Tag CoIP	33961781
Intra	ARHGEF7	Q14155	GIT1	Homo sapiens	Q9Y2X7	Anti Bait CoIP	16628223
Intra	ARHGEF7	Q14155	GIT1	Homo sapiens	Q9Y2X7	Anti Bait CoIP	21295525
Intra	ARHGEF7	Q14155	GIT1	Homo sapiens	Q9Y2X7	Anti Tag CoIP	35271311
Intra	ARHGEF7	Q14155	CBL	Homo sapiens	P22681	Pull Down	16407834
Intra	ARHGEF7	Q14155	CBL	Homo sapiens	P22681	Anti Bait CoIP	16407834
Intra	ARHGEF7	Q14155	CBL	Homo sapiens	P22681	Anti Tag CoIP	16407834
Intra	ARHGEF7	Q14155	LRRK2	Homo sapiens	Q5S007	Protein Kinase Assay	21048939
Intra	ARHGEF7	Q14155	LRRK2	Homo sapiens	Q5S007	Confocal	21048939
Intra	ARHGEF7	Q14155	LRRK2	Homo sapiens	Q5S007	Anti Tag CoIP	21048939
Intra	ARHGEF7	Q14155	NAA10	Homo sapiens	P41227	Anti Tag CoIP	21295525
Intra	ARHGEF7	Q14155	NAA10	Homo sapiens	P41227	Anti Bait CoIP	21295525
Intra	ARHGEF7	Q14155	MEOX2	Homo sapiens	P50222	Y2H Array	25416956
Intra	ARHGEF7	Q14155	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability	Non-Specific X-Linked Mental Retardation
X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00964	ARHGEF7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ARHGEF7	VGNC	VGNC:26121
Macaca mulatta	ARHGEF7	VGNC	VGNC:69833
Mus musculus	ARHGEF7	MGD	MGI:1860493
Felis catus	ARHGEF7	VGNC	VGNC:59909
Canis familiaris	ARHGEF7	VGNC	VGNC:54920
Rattus norvegicus	ARHGEF7	RGD	RGD:620624
Others	ARHGEF7	NCBI

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