GAB2 - GRB2 associated binding protein 2 Gene

Homo sapiens

Gene ID: 9846 | Gene type: protein coding

About GAB2

Cytogenetic location: 11q14.1 Genomic coordinates (GRCh38): 11:78,215,293-78,417,820 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues and 7 paralogues. Ubiquitous expression in brain (RPKM 13.2), bone marrow (RPKM 11.6) and 25 other tissues.

Summary

This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine Phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]

GAB2 Products(2)

mRNA	Protein	Name
NM_012296.4	NP_036428.1	GRB2-associated-binding protein 2 isoform b
NM_080491.3	NP_536739.1	GRB2-associated-binding protein 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15170389	GOA
enables transmembrane receptor protein tyrosine kinase adaptor activity	IDA IDA: Inferred from direct assay	19172738	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	15750601	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	19172738	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19172738	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19172738	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GAB2 Protein Structure

0
200
400
600
676 a.a.

Protein Preferred Names

Protein Names

GRB2-associated-binding protein 2

Grb2-associated binder 2

GAB2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GAB2	Q9UQC2	ACP2	Homo sapiens	P11117	Y2H Pooling	32814053
Intra	GAB2	Q9UQC2	ACP2	Homo sapiens	P11117	Validated Y2H	32814053
Intra	GAB2	Q9UQC2	ACP2	Homo sapiens	P11117	Y2H Array	32814053
Intra	GAB2	Q9UQC2	EGFR	Homo sapiens	P00533	Anti Tag CoIP	19172738
Intra	GAB2	Q9UQC2	EGFR	Homo sapiens	P00533	Anti Tag CoIP	16253990
Intra	GAB2	Q9UQC2	PTPN11	Homo sapiens	Q06124	Anti Tag CoIP	16253990
Intra	GAB2	Q9UQC2	PTPN11	Homo sapiens	Q06124	Anti Bait CoIP	19172738
Intra	GAB2	Q9UQC2	YWHAB	Homo sapiens	P31946	Far-WB	19172738
Intra	GAB2	Q9UQC2	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	19172738
Intra	GAB2	Q9UQC2	GRB2	Homo sapiens	P62993	Anti Bait CoIP	19172738
Intra	GAB2	Q9UQC2	GRB2	Homo sapiens	P62993	Pull Down	10913131
Intra	GAB2	Q9UQC2	GRB2	Homo sapiens	P62993	Anti Tag CoIP	31980649
Intra	GAB2	Q9UQC2	GRB2	Homo sapiens	P62993	Y2H Prey Pooling	25416956
Intra	GAB2	Q9UQC2	GRB2	Homo sapiens	P62993	Validated Y2H	25416956
Intra	GAB2	Q9UQC2	GRB2	Homo sapiens	P62993	Y2H Prey Pooling	32296183
Intra	GAB2	Q9UQC2	GRB2	Homo sapiens	P62993	Y2H Pooling	20936779
Intra	GAB2	Q9UQC2	GRB2	Homo sapiens	P62993	Y2H Array	25416956
Intra	GAB2	Q9UQC2	GRB2	Homo sapiens	P62993	Y2H Array	32296183
Intra	GAB2	Q9UQC2	GRB2	Homo sapiens	P62993	Anti Tag CoIP	16253990
Intra	GAB2	Q9UQC2	GRAP2	Homo sapiens	O75791	Y2H Prey Pooling	32296183
Intra	GAB2	Q9UQC2	GRAP2	Homo sapiens	O75791	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

Alzheimer'S Disease 1

Alzheimer Disease Type 1

Alzheimer'S Disease 1, Early Onset

Juvenile Myelomonocytic Leukemia

Leukemia, Juvenile Myelomonocytic	JMML
Leukemia, Juvenile Myelomonocytic, Somatic	Juvenile Chronic Myelomonocytic Leukemia
Juvenile Chronic Myelogenous Leukemia	Leukemia, Myelomonocytic, Juvenile
Juvenile Myelomonocytic Leukaemia Without Mention Of Remission

Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome

Noonan Syndrome 1

Noonan Syndrome	NS1
Male Turner Syndrome	Female Pseudo-Turner Syndrome
Turner Phenotype With Normal Karyotype	Noonan Syndrome With Pigmented Villonodular Synovitis
Turner'S Phenotype, Karyotype Normal	Familial Turner Syndrome
Noonan'S Syndrome	Noonan-Ehmke Syndrome
Ns	Pseudo-Ullrich-Turner Syndrome
Turner Syndrome In Female With X Chromosome	Turner-Like Syndrome
Ullrich-Noonan Syndrome	Noonan-Like/Multiple Giant Cell Lesion Syndrome
Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions	Pterygium Colli Syndrome
Noonan Syndrome, Type 1	Turner Syndrome, Male

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05198	GAB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GAB2	VGNC	VGNC:103013
Macaca mulatta	GAB2	VGNC	VGNC:72721
Rattus norvegicus	GAB2	RGD	RGD:621367
Mus musculus	GAB2	MGD	MGI:1333854

Name
Email *

	Sorry, but the email address you supplied was invalid.