MED24 - mediator complex subunit 24 Gene

Homo sapiens

Also known as MED5; CRSP4; ARC100; THRAP4; CRSP100; DRIP100; TRAP100

Gene ID: 9862 | Gene type: protein coding

About MED24

Cytogenetic location: 17q21.1 Genomic coordinates (GRCh38): 17:40,019,104-40,054,408 (from NCBI)

This gene has 33 transcripts (splice variants) and 220 orthologues. Ubiquitous expression in testis (RPKM 18.9), brain (RPKM 13.4) and 25 other tissues.

Summary

This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

MED24 Products(4)

mRNA	Protein	Name
NM_001079518.2	NP_001072986.1	mediator of RNA polymerase II transcription subunit 24 isoform 2
NM_001267797.2	NP_001254726.1	mediator of RNA polymerase II transcription subunit 24 isoform 2
NM_001330211.2	NP_001317140.1	mediator of RNA polymerase II transcription subunit 24 isoform 3
NM_014815.4	NP_055630.2	mediator of RNA polymerase II transcription subunit 24 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables nuclear thyroid hormone receptor binding	IDA IDA: Inferred from direct assay	10198638	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24882805	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	12218053	GOA
enables transcription coregulator activity	IDA IDA: Inferred from direct assay	10198638	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10198638	GOA
involved in positive regulation of transcription initiation by RNA polymerase II	IDA IDA: Inferred from direct assay	12218053	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of core mediator complex	IPI IPI: Inferred from physical interaction	24882805	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10235267	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED24 Protein Structure

Med24_N

0
200
400
600
800
989 a.a.

Protein Preferred Names

Protein Names

mediator of RNA polymerase II transcription subunit 24

CRSP complex subunit 4

MED24 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MED24	O75448	MED14	Homo sapiens	O60244	Anti Tag CoIP	33961781
Intra	MED24	O75448	MED16	Homo sapiens	Q9Y2X0	Anti Tag CoIP	33961781
Intra	MED24	O75448	MED25	Homo sapiens	Q71SY5	Anti Tag CoIP	33961781
Intra	MED24	O75448	MED25	Homo sapiens	Q71SY5	Anti Tag CoIP	24882805

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08295	MED24 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16294	Med24 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MED24	RGD	RGD:1564565
Bos taurus	MED24	VGNC	VGNC:31361
Felis catus	MED24	VGNC	VGNC:63438
Mus musculus	MED24	MGD	MGI:1344385
Canis familiaris	MED24	VGNC	VGNC:43132

Name
Email *

	Sorry, but the email address you supplied was invalid.