MED25 - mediator complex subunit 25 Gene

Homo sapiens

Also known as P78; ACID1; ARC92; BVSYS; PTOV2; CMT2B2; TCBAP0758

Gene ID: 81857 | Gene type: protein coding

About MED25

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,818,289-49,840,384 (from NCBI)

This gene has 8 transcripts (splice variants), 197 orthologues, 1 paralogue and is associated with 6 phenotypes. Broad expression in testis (RPKM 24.2), adrenal (RPKM 11.6) and 25 other tissues.

Summary

This gene encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2. [provided by RefSeq, Apr 2010]

MED25 Products(2)

mRNA	Protein	Name
NM_001378355.1	NP_001365284.1	mediator of RNA polymerase II transcription subunit 25 isoform 2
NM_030973.4	NP_112235.2	mediator of RNA polymerase II transcription subunit 25 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables nuclear retinoic acid receptor binding	IPI IPI: Inferred from physical interaction	17641689	GOA
enables nuclear retinoid X receptor binding	IPI IPI: Inferred from physical interaction	17641689	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17641689	GOA
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	17641689	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	17641689	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17641689	GOA
involved in positive regulation of chromatin binding	IMP IMP: Inferred from mutant phenotype	17641689	GOA
involved in positive regulation of mediator complex assembly	IMP IMP: Inferred from mutant phenotype	17641689	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17641689	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of core mediator complex	IPI IPI: Inferred from physical interaction	24882805	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24882805	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED25 Protein Structure

Med25_VWA

Med25_SD1

Med25

Med25_NR-box

0
200
400
600
747 a.a.

Protein Preferred Names

Protein Names

mediator of RNA polymerase II transcription subunit 25

ARC/mediator transcriptional coactivator subunit

MED25 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MED25	Q71SY5	ESRP1	Homo sapiens	Q6NXG1	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	ESRP1	Homo sapiens	Q6NXG1	Y2H Array	32296183
Intra	MED25	Q71SY5	NCKIPSD	Homo sapiens	Q9NZQ3-3	Y2H Array	32296183
Intra	MED25	Q71SY5	NCKIPSD	Homo sapiens	Q9NZQ3-3	Validated Y2H	32296183
Intra	MED25	Q71SY5	NCKIPSD	Homo sapiens	Q9NZQ3-3	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	MED25	Q71SY5	STAT5B	Homo sapiens	P51692	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	STAT5B	Homo sapiens	P51692	Y2H Array	32296183
Intra	MED25	Q71SY5	USP54	Homo sapiens	Q70EL1-9	Y2H Array	32296183
Intra	MED25	Q71SY5	USP54	Homo sapiens	Q70EL1-9	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	WWOX	Homo sapiens	Q9NZC7-5	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	WWOX	Homo sapiens	Q9NZC7-5	Validated Y2H	32296183
Intra	MED25	Q71SY5	WWOX	Homo sapiens	Q9NZC7-5	Y2H Array	32296183
Intra	MED25	Q71SY5	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Array	32296183
Intra	MED25	Q71SY5	FAM168B	Homo sapiens	A1KXE4-2	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	FAM168B	Homo sapiens	A1KXE4-2	Y2H Array	32296183
Intra	MED25	Q71SY5	EYA2	Homo sapiens	O00167-2	Y2H Array	32296183
Intra	MED25	Q71SY5	EYA2	Homo sapiens	O00167-2	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	OXER1	Homo sapiens	Q8TDS5	Y2H Array	32296183
Intra	MED25	Q71SY5	OXER1	Homo sapiens	Q8TDS5	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	OXER1	Homo sapiens	Q8TDS5	Validated Y2H	32296183
Intra	MED25	Q71SY5	RORB	Homo sapiens	Q92753-1	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	RORB	Homo sapiens	Q92753-1	Validated Y2H	32296183
Intra	MED25	Q71SY5	RORB	Homo sapiens	Q92753-1	Y2H Array	32296183
Intra	MED25	Q71SY5	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Array	32296183
Intra	MED25	Q71SY5	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	MED23	Homo sapiens	Q9ULK4	Anti Tag CoIP	24882805
Intra	MED25	Q71SY5	MED23	Homo sapiens	Q9ULK4	Anti Tag CoIP	25792360
Intra	MED25	Q71SY5	TFG	Homo sapiens	Q92734	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	TFG	Homo sapiens	Q92734	Validated Y2H	32296183
Intra	MED25	Q71SY5	TFG	Homo sapiens	Q92734	Y2H Array	32296183
Intra	MED25	Q71SY5	PLEKHB2	Homo sapiens	Q96CS7	Y2H Array	32296183
Intra	MED25	Q71SY5	PLEKHB2	Homo sapiens	Q96CS7	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	PLEKHB2	Homo sapiens	Q96CS7	Validated Y2H	32296183
Intra	MED25	Q71SY5	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	MED25	Q71SY5	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	MED14	Homo sapiens	O60244	Anti Tag CoIP	24882805
Intra	MED25	Q71SY5	MED14	Homo sapiens	O60244	Anti Tag CoIP	25792360
Intra	MED25	Q71SY5	MED15	Homo sapiens	Q96RN5	Anti Tag CoIP	24882805
Intra	MED25	Q71SY5	MED24	Homo sapiens	O75448	Anti Tag CoIP	35271311
Intra	MED25	Q71SY5	MED24	Homo sapiens	O75448	Anti Tag CoIP	25792360
Intra	MED25	Q71SY5	MED16	Homo sapiens	Q9Y2X0	Anti Tag CoIP	25792360
Intra	MED25	Q71SY5	MED16	Homo sapiens	Q9Y2X0	Anti Tag CoIP	35271311
Intra	MED25	Q71SY5	RARA	Homo sapiens	P10276	Y2H	17641689
Intra	MED25	Q71SY5	ODAM	Homo sapiens	A1E959	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	ODAM	Homo sapiens	A1E959	Y2H Array	32296183
Intra	MED25	Q71SY5	RUSC1	Homo sapiens	Q9BVN2	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	RUSC1	Homo sapiens	Q9BVN2	Validated Y2H	32296183
Intra	MED25	Q71SY5	RUSC1	Homo sapiens	Q9BVN2	Y2H Array	32296183
Intra	MED25	Q71SY5	PEF1	Homo sapiens	Q9UBV8	Validated Y2H	32296183
Intra	MED25	Q71SY5	PEF1	Homo sapiens	Q9UBV8	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	PEF1	Homo sapiens	Q9UBV8	Y2H Array	32296183
Intra	MED25	Q71SY5	HGS	Homo sapiens	O14964	Y2H Array	32296183
Intra	MED25	Q71SY5	HGS	Homo sapiens	O14964	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	KLHL12	Homo sapiens	Q53G59	Y2H Array	32296183
Intra	MED25	Q71SY5	KLHL12	Homo sapiens	Q53G59	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	WWP2	Homo sapiens	O00308	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	WWP2	Homo sapiens	O00308	Y2H Array	32296183
Intra	MED25	Q71SY5	SERTAD3	Homo sapiens	Q9UJW9	Validated Y2H	32296183
Intra	MED25	Q71SY5	SERTAD3	Homo sapiens	Q9UJW9	Y2H Array	32296183
Intra	MED25	Q71SY5	SERTAD3	Homo sapiens	Q9UJW9	Y2H Prey Pooling	32296183
Intra	MED25	Q71SY5	RXRA	Homo sapiens	P19793	Anti Tag CoIP	17641689
Intra	MED25	Q71SY5	LASP1	Homo sapiens	Q14847-2	Y2H Array	32296183
Intra	MED25	Q71SY5	LASP1	Homo sapiens	Q14847-2	Y2H Prey Pooling	32296183
Cross	MED25	Q71SY5	UL48	Human herpesvirus 1	G8HBG2	Pull Down	21378963
Cross	MED25	Q71SY5	UL48	Human herpesvirus 1	G8HBG2	ITC	21378963
Cross	MED25	Q71SY5	UL48	Human herpesvirus 1	G8HBG2	NMR	21378963
Cross	MED25	Q71SY5	UL48	Human herpesvirus 1	G8HBG2	EMSA	21378965
Cross	MED25	Q71SY5	UL48	Human herpesvirus 1	G8HBG2	NMR	21378965

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Basel-Vanagaite-Smirin-Yosef Syndrome

BVSYS

Basel-Vanagait-Smirin-Yosef Syndrome

Charcot-Marie-Tooth Disease, Axonal, Type 2b2

Charcot-Marie-Tooth Disease Type 2b2	CMT2B2
Arcmt2b	Charcot-Marie-Tooth Disease, Type 2b2
Ar-Cmt2b2	Autosomal Recessive Axonal Charcot-Marie-Tooth Disease Type 2b2
Autosomal Recessive Axonal Cmt4c3	Charcot-Marie-Tooth Disease Neuronal Type 2b2
Charcot-Marie-Tooth Neuropathy Type 2b2	Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2b2
Charcot-Marie-Tooth Disease, Neuronal, Type 2b2	Charcot-Marie-Tooth Neuropathy, Type 2b2
Charcot-Marie-Tooth Disease 2b2	Charcot-Marie-Tooth Disease Axonal Autosomal Recessive B2
Charcot-Marie-Tooth Disease Axonal Type 2b2

Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

Tooth Disease

Tooth Diseases	Teeth Disease
Tooth Disorders

Herpes Simplex

Herpes Simplex Infections	Herpesvirus Hominis Disease
Herpes Simplex Disease	Herpesviral Infection Due To Herpes Simplex
Infections Due To Simplex Virus	Herpes Nos

Charcot-Marie-Tooth Disease, Axonal, Type 2i

CMT2I	Charcot-Marie-Tooth Disease, Type 2i
Charcot-Marie-Tooth Disease Type 2i	Charcot-Marie-Tooth Neuropathy Type 2i
Charcot-Marie-Tooth Neuropathy, Type 2i	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2i
Charcot-Marie-Tooth Disease 2i	Charcot-Marie-Tooth Disease Axonal Type 2i
Charcot-Marie-Tooth Disease Neuronal Type 2i

Charcot-Marie-Tooth Disease And Deafness

Charcot-Marie-Tooth Disease Type 1e	CMT1E
Charcot-Marie-Tooth Disease Type 1	Hereditary Motor And Sensory Neuropathy Type 1
Charcot-Marie-Tooth Disease, Demyelinating, Type 1e	Charcot-Marie-Tooth Disease, Type I
Charcot-Marie-Tooth Neuropathy And Deafness, Autosomal Dominant	Charcot-Marie-Tooth Disease, Type 1e
Charcot-Marie-Tooth Disease Demyelinating Type 1e	Autosomal Dominant Demyelinating Charcot-Marie-Tooth Disease
Cmt1	Charcot-Marie-Tooth Neuropathy Type 1
Autosomal Dominant Charcot-Marie-Tooth Neuropathy And Deafness	Charcot-Marie-Tooth Disease-Deafness
Charcot-Marie-Tooth Type 1	Hmsn1
Hereditary Motor And Sensory Neuropathy 1	Cmt 1e
Charcot Marie Tooth Disease Type 1e	Charcot-Marie-Tooth Disease-Deafness Syndrome
Charcot-Marie-Tooth Disease-Hearing Loss Syndrome	Charcot-Marie-Tooth Disease 1e
Charcot-Marie-Tooth Disease And Deafness Autosomal Dominant	Charcot-Marie-Tooth Neuropathy Type 1e
Charcot-Marie-Tooth Disease, Type Ie	Hereditary Motor And Sensory Neuropathy Type I

Male Reproductive Organ Benign Neoplasm

Polymicrogyria

Pmg

Prostatic Adenoma

Prostatic Hyperplasia	Adenoma - Prostate
Adenoma Of Prostate	Benign Adenoma Of Prostate
Prostate Adenoma	Benign Prostatic Hyperplasia

Polymicrogyria, Bilateral Perisylvian, X-Linked

Bilateral Perisylvian Polymicrogyria	Polymicrogyria, Bilateral Perisylvian
Pmgx	Perisylvian Syndrome, Congenital Bilateral
Cbps	Congenital Bilateral Perisylvian Syndrome
Perisylvian Syndrome	BPPX
Bpp

Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive

Charcot-Marie-Tooth Disease Type 4	Charcot-Marie-Tooth Disease Type 4e
Hereditary Motor And Sensory Neuropathy	Cmt4e
CHN1	Hypomyelinating Neuropathy, Congenital, 1
Charcot-Marie-Tooth Neuropathy Type 4e	Neuropathy, Congenital Hypomyelinating, 1
Ar-Cmt1	Autosomal Recessive Demyelinating Charcot-Marie-Tooth
Cmt4	Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive
Hypomyelination, Severe Congenital	Charcot-Marie-Tooth Disease, Type 4e
Charcot-Marie-Tooth Neuropathy, Type 4e	Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy
Autosomal Recessive Congenital Hypomyelinating Neuropathy	Congenital Amyelinating Neuropathy
Congenital Hypomyelinating Neuropathy Autosomal Recessive	Neuropathy, Congenital Hypomyelinating Or Amyelinating
Severe Congenital Hypomyelination	Hereditary Sensory Motor Neuropathy
Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive	Neuropathy, Hypomyelinating, Congenital, Type 1
Neuropathy, Motor And Sensory, Hereditary	Congenital Hypomyelinating Neuropathy
Hereditary Motor And Sensory Neuropathies	Hereditary Sensorimotor Neuropathy
Hmsn - [Hereditary Motor And Sensory Neuropathy]	Hsmn - [Hereditary Sensory And Motor Neuropathy]
Hereditary Motor And Sensory Neuropathy, Types I-Iv

Hypertrophic Neuropathy Of Dejerine-Sottas

Dejerine-Sottas Disease	Dejerine-Sottas Syndrome
Charcot-Marie-Tooth Disease Type 3	DSS
Hereditary Motor And Sensory Neuropathy Type Iii	Hmsn3
Dejerine-Sottas Neuropathy	Hmsn Iii
Charcot-Marie-Tooth Disease, Type 3	Cmt3
Dsn	Hmsn 3
Hereditary Motor And Sensory Neuropathy Type 3	Hereditary Motor And Sensory Neuropathy 3
Hypertrophic Neuropathy Of Infancy	Charcot-Marie-Tooth Disease Demyelinating Type 4f
Charcot-Marie-Tooth Disease Type 4f	Charcot-Marie-Tooth Neuropathy Type 4f
Cmt4f	Hereditary Motor And Sensory Neuropathy Iii
Charcot-Marie-Tooth Disease, Demyelinating, Type 4f

Charcot-Marie-Tooth Disease, Axonal, Type 2e

Charcot-Marie-Tooth Disease Type 2	CMT2E
CMT2S	CMT2Y
Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Disease Type 2y
Charcot-Marie-Tooth Disease Axonal Type 2s	Charcot-Marie-Tooth Disease, Axonal, Type 2s
Charcot-Marie-Tooth Disease, Type 2e	Hereditary Motor And Sensory Neuropathy Type 2
Charcot-Marie-Tooth Neuropathy, Type 2s	Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s
Charcot-Marie-Tooth Disease, Axonal, Type 2y	Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y
Charcot-Marie-Tooth Neuropathy, Type 2y	Charcot-Marie-Tooth Disease, Type 2y
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Neuropathy Type 2e
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation	Cmt2 Due To Vcp Mutation
Charcot-Marie-Tooth Disease Type 2s	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2
Autosomal Dominant Axonal Charcot-Marie-Tooth Disease	Cmt2
Charcot-Marie-Tooth Neuropathy, Type 2e	Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type
Hereditary Motor And Sensory Neuropathy Okinawa Type	Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y
Charcot-Marie-Tooth Neuropathy Type 2y	Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s
Charcot-Marie-Tooth Neuropathy Type 2s	Charcot-Marie-Tooth Type 2
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y	Charcot-Marie-Tooth Disease 2e
Charcot-Marie-Tooth Disease Axonal Type 2e	Charcot-Marie-Tooth Disease Neuronal Type 2e
Charcot-Marie-Tooth Disease 2s	Charcot-Marie-Tooth Neuropathy Axonal Type 2s
Charcot-Marie-Tooth Disease 2y	Charcot-Marie-Tooth Disease, Type 2
Hereditary Motor And Sensory-Neuropathy Type Ii

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08296	MED25 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MED25	MGD	MGI:1922863
Canis familiaris	MED25	VGNC	VGNC:43133
Felis catus	MED25	VGNC	VGNC:63439
Rattus norvegicus	MED25	RGD	RGD:1305137
Bos taurus	MED25	VGNC	VGNC:31362
Macaca mulatta	MED25	VGNC	VGNC:74607

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