MED16 - mediator complex subunit 16 Gene

Homo sapiens

Also known as DRIP92; THRAP5; TRAP95

Gene ID: 10025 | Gene type: protein coding

About MED16

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:867,963-893,187 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele and 200 orthologues. Ubiquitous expression in ovary (RPKM 10.5), kidney (RPKM 10.1) and 25 other tissues.

Summary

Enables Thyroid Hormone Receptor binding activity and transcription coactivator activity. Involved in positive regulation of transcription initiation from RNA polymerase II promoter. Located in membrane. Part of mediator complex. [provided by Alliance of Genome Resources, Apr 2022]

MED16 Products(1)

mRNA	Protein	Name
NM_005481.3	NP_005472.2	mediator of RNA polymerase II transcription subunit 16

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables nuclear thyroid hormone receptor binding	IDA IDA: Inferred from direct assay	10198638	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24882805	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	10198638	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10198638	GOA
involved in positive regulation of transcription initiation by RNA polymerase II	IDA IDA: Inferred from direct assay	12218053	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of core mediator complex	IPI IPI: Inferred from physical interaction	24882805	GOA
part of mediator complex	IDA IDA: Inferred from direct assay	10198638	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24882805	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED16 Protein Structure

WD40

Med16

0
200
400
600
800
877 a.a.

Protein Preferred Names

Protein Names

mediator of RNA polymerase II transcription subunit 16

thyroid hormone receptor-associated protein 5

MED16 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MED16	Q9Y2X0	MED23	Homo sapiens	Q9ULK4	Anti Tag CoIP	24882805
Intra	MED16	Q9Y2X0	MED14	Homo sapiens	O60244	Anti Tag CoIP	24882805
Intra	MED16	Q9Y2X0	MED24	Homo sapiens	O75448	Anti Tag CoIP	24882805
Intra	MED16	Q9Y2X0	MED25	Homo sapiens	Q71SY5	Anti Tag CoIP	24882805

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Mixed Fibrolamellar Hepatocellular Carcinoma

Lipodystrophy, Congenital Generalized, Type 3

Congenital Generalized Lipodystrophy Type 3	CGL3
Bscl3	Berardinelli-Seip Congenital Lipodystrophy Type 3
Berardinelli-Seip Congenital Lipodystrophy, Type 3	Lipodystrophy, Berardinelli-Seip Congenital, Type 3
Type 3 Berardinelli-Seip Congenital Lipodystrophy	Congenital Generalized Lipodystrophy 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08287	MED16 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MED16	VGNC	VGNC:31354
Canis familiaris	MED16	VGNC	VGNC:43126
Mus musculus	MED16	MGD	MGI:2158394
Felis catus	MED16	VGNC	VGNC:80624
Rattus norvegicus	MED16	RGD	RGD:1308001
Macaca mulatta	MED16	VGNC	VGNC:74525

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