MED14 - mediator complex subunit 14 Gene

Homo sapiens

Also known as CSRP; RGR1; CRSP2; EXLM1; CXorf4; CRSP150; DRIP150; TRAP170

Gene ID: 9282 | Gene type: protein coding

About MED14

Cytogenetic location: Xp11.4 Genomic coordinates (GRCh38): X:40,648,305-40,736,159 (from NCBI)

This gene has 9 transcripts (splice variants) and 215 orthologues. Ubiquitous expression in thyroid (RPKM 8.7), duodenum (RPKM 8.0) and 25 other tissues.

Summary

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. [provided by RefSeq, Jul 2008]

MED14 Products(1)

mRNA	Protein	Name
NM_004229.4	NP_004220.2	mediator of RNA polymerase II transcription subunit 14

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24882805	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	12037571	GOA
enables transcription coregulator activity	IDA IDA: Inferred from direct assay	10198638	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10198638	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12037571	GOA
involved in positive regulation of transcription initiation by RNA polymerase II	IDA IDA: Inferred from direct assay	12218053	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of core mediator complex	IPI IPI: Inferred from physical interaction	24882805	GOA
part of mediator complex	IDA IDA: Inferred from direct assay	10198638	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10235267	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED14 Protein Structure

Med14

0
300
600
900
1200
1454 a.a.

Protein Preferred Names

Protein Names

mediator of RNA polymerase II transcription subunit 14

ARC150

MED14 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MED14	O60244	MED23	Homo sapiens	Q9ULK4	Anti Tag CoIP	35271311
Intra	MED14	O60244	MED15	Homo sapiens	Q96RN5	Anti Tag CoIP	35271311
Intra	MED14	O60244	MED24	Homo sapiens	O75448	Anti Tag CoIP	24882805
Intra	MED14	O60244	MED24	Homo sapiens	O75448	Anti Tag CoIP	35271311
Intra	MED14	O60244	MED16	Homo sapiens	Q9Y2X0	Anti Tag CoIP	35271311
Intra	MED14	O60244	MED16	Homo sapiens	Q9Y2X0	Anti Tag CoIP	24882805
Intra	MED14	O60244	MED25	Homo sapiens	Q71SY5	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Mixed Phenotype Acute Leukemia, T/Myeloid

Doid:0081039

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08285	MED14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MED14	MGD	MGI:1349442
Felis catus	MED14	VGNC	VGNC:63435
Canis familiaris	MED14	VGNC	VGNC:43124
Rattus norvegicus	MED14	RGD	RGD:1560170
Bos taurus	MED14	VGNC	VGNC:31352
Macaca mulatta	MED14	VGNC	VGNC:74561

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