SRGAP3 - SLIT-ROBO Rho GTPase activating protein 3 Gene

Homo sapiens

Also known as WRP; MEGAP; SRGAP2; ARHGAP14

Gene ID: 9901 | Gene type: protein coding

About SRGAP3

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:8,980,591-9,363,027 (from NCBI)

This gene has 12 transcripts (splice variants), 262 orthologues, 5 paralogues and is associated with 90 phenotypes. Broad expression in brain (RPKM 6.5), urinary bladder (RPKM 1.5) and 16 other tissues.

Summary

Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of cell migration. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SRGAP3 Products(2)

mRNA	Protein	Name
NM_001033117.3	NP_001028289.1	SLIT-ROBO Rho GTPase-activating protein 3 isoform b
NM_014850.4	NP_055665.1	SLIT-ROBO Rho GTPase-activating protein 3 isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17500595	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in postsynapse	IDA IDA: Inferred from direct assay	30123108	GOA
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	30123108	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRGAP3 Protein Structure

FCH

RhoGAP

SH3_1

0
200
400
600
800
1000
1099 a.a.

Protein Preferred Names

Protein Names

SLIT-ROBO Rho GTPase-activating protein 3

SLIT-ROBO Rho GTPase activating protein 2

Related Diseases

Diseases

Alias

Pilomyxoid Astrocytoma

Chromosome 3pter-P25 Deletion Syndrome

3p- Syndrome	3p Deletion Syndrome
Distal Monosomy 3p	Chromosome 3, Monosomy 3p
3p Partial Monosomy Syndrome	Chromosome 3, Deletion 3p
Chromosome 3p Deletion Syndrome	Del Syndrome
Deletion 3p	Monosomy 3p
Partial Monosomy 3p	Distal 3p Deletion
Monosomy 3pter	Telomeric Monosomy 3p
Chromosome Deletion Syndrome 3pter-P25

Lissencephaly 5

LIS5	Cobblestone Lissencephaly Without Muscular Or Ocular Involvement
Cobblestone Lissencephaly Without Muscular Or Eye Involvement	Lissencephaly Type 2 Without Muscular Or Eye Involvement
Lissencephaly Type 2 Without Muscular Or Ocular Involvement	Lissencephaly, Type 5

Avoidant Personality Disorder

Anxious Personality Disorder

Personality Disorders

Retinitis Pigmentosa 23

RP23	Retinitis Pigmentosa-23
Retinitis Pigmentosa, Type 23	Rp23 Gene

Fibrillary Astrocytoma

Fibrillary Astrocytic Tumors	Diffuse Astrocytoma
Gemistocytic Astrocytoma	Protoplasmic Astrocytoma

Childhood Astrocytic Tumor

Juvenile Astrocytoma

Pediatric Astrocytoma

Pilocytic Astrocytoma

Juvenile Pilocytic Astrocytoma	Grade I Astrocytic Tumor
Piloid Astrocytoma

Early Infantile Epileptic Encephalopathy

Early Infantile Epileptic Encephalopathy With Burst-Suppression	Early Infantile Epileptic Encephalopathy With Suppression Bursts
Eiee	Early Infantile Epileptic Encephalopathy With Suppression-Bursts
Ohtahara Syndrome	Encephalopathy, Epileptic, Early Infantile

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13765	SRGAP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SRGAP3	VGNC	VGNC:46802
Macaca mulatta	SRGAP3	VGNC	VGNC:77968
Bos taurus	SRGAP3	VGNC	VGNC:35279
Rattus norvegicus	SRGAP3	RGD	RGD:1563152
Felis catus	SRGAP3	VGNC	VGNC:65680
Mus musculus	SRGAP3	MGD	MGI:2152938

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