THOC5 - THO complex subunit 5 Gene

Homo sapiens

Also known as Fmip; PK1.3; fSAP79; C22orf19

Gene ID: 8563 | Gene type: protein coding

About THOC5

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:29,505,879-29,553,757 (from NCBI)

This gene has 17 transcripts (splice variants) and 223 orthologues. Ubiquitous expression in testis (RPKM 10.3), endometrium (RPKM 6.9) and 25 other tissues.

Summary

Predicted to enable mRNA binding activity. Involved in several processes, including monocyte differentiation; negative regulation of DNA damage checkpoint; and viral mRNA export from host cell nucleus. Located in nucleoplasm. Part of THO complex part of transcription export complex. Colocalizes with chromosome, telomeric region. Implicated in breast carcinoma. [provided by Alliance of Genome Resources, Apr 2022]

THOC5 Products(4)

mRNA	Protein	Name
NM_001002877.2	NP_001002877.1	THO complex subunit 5 homolog
NM_001002878.1	NP_001002878.1	THO complex subunit 5 homolog
NM_001002879.1	NP_001002879.1	THO complex subunit 5 homolog
NM_003678.5	NP_003669.4	THO complex subunit 5 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19059247	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA export from nucleus	IDA IDA: Inferred from direct assay	17190602	GOA
involved in mRNA export from nucleus	IMP IMP: Inferred from mutant phenotype	22144908	GOA
involved in monocyte differentiation	IDA IDA: Inferred from direct assay	19015024	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of THO complex	IDA IDA: Inferred from direct assay	15998806	GOA
part of THO complex part of transcription export complex	IDA IDA: Inferred from direct assay	15998806	GOA
colocalizes with chromosome, telomeric region	IDA IDA: Inferred from direct assay	24270157	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19059247	GOA
part of transcription export complex	IDA IDA: Inferred from direct assay	15833825	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THOC5 Protein Structure

FimP

0
200
400
600
683 a.a.

Protein Preferred Names

Protein Names

THO complex subunit 5 homolog

Fms-interacting protein

THOC5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	THOC5	Q13769	THOC1	Homo sapiens	Q96FV9	Anti Tag CoIP	23299939
Intra	THOC5	Q13769	THOC1	Homo sapiens	Q96FV9	Anti Tag CoIP	19059247
Intra	THOC5	Q13769	THOC1	Homo sapiens	Q96FV9	Anti Tag CoIP	26496610
Intra	THOC5	Q13769	THOC7	Homo sapiens	Q6I9Y2	Anti Tag CoIP	19059247
Intra	THOC5	Q13769	THOC7	Homo sapiens	Q6I9Y2	IF	19059247
Intra	THOC5	Q13769	THOC7	Homo sapiens	Q6I9Y2	Pull Down	19059247
Intra	THOC5	Q13769	THOC7	Homo sapiens	Q6I9Y2	Anti Tag CoIP	26496610
Intra	THOC5	Q13769	TAP1	Homo sapiens	Q03518	Pull Down	19165146

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14494	THOC5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	THOC5	VGNC	VGNC:79178
Felis catus	THOC5	VGNC	VGNC:80500
Bos taurus	THOC5	VGNC	VGNC:35841
Mus musculus	THOC5	MGD	MGI:1351333
Canis familiaris	THOC5	VGNC	VGNC:47351
Rattus norvegicus	THOC5	RGD	RGD:1304991

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