1. Anti-infection Cell Cycle/DNA Damage
  2. Antibiotic Bacterial Topoisomerase
  3. Gepotidacin mesylate hydrate

Gepotidacin mesylate hydrate is an orally active triazaacenaphthylene antibiotic and bacterial type II topoisomerase inhibitor. Gepotidacin mesylate hydrate inhibits bacterial DNA replication by blocking topoisomerase enzymes. Gepotidacin mesylate hydrate selectively inhibits topoisomerase IV and the B subunit of DNA gyrase.

For research use only. We do not sell to patients.

Gepotidacin mesylate hydrate Chemical Structure

Gepotidacin mesylate hydrate Chemical Structure

CAS No. : 1624306-20-2

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Description

Gepotidacin mesylate hydrate is an orally active triazaacenaphthylene antibiotic and bacterial type II topoisomerase inhibitor. Gepotidacin mesylate hydrate inhibits bacterial DNA replication by blocking topoisomerase enzymes. Gepotidacin mesylate hydrate selectively inhibits topoisomerase IV and the B subunit of DNA gyrase[1][2].

In Vitro

Gepotidacin is a potent inhibitor of gyrase-catalyzed DNA supercoiling (IC50 ≈ 0.047 μM) and relaxation of positively supercoiled substrates (IC50 ≈ 0.6 μM)[1].
The MIC of Gepotidacin for E. coli isolates in Mueller-Hinton broth ranged from 1 to 4 mg/L[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

580.65

Formula

C25H36N6O8S

CAS No.
SMILES

O=C(C=NC(C=C1)=C23)N3[C@H](CN4CCC(NCC5=CC(CCCO6)=C6C=N5)CC4)CN2C1=O.CS(=O)(O)=O.O.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Gepotidacin mesylate hydrate Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Gepotidacin mesylate hydrate
Cat. No.:
HY-16742B
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