Gepotidacin mesylate hydrate

Name: Gepotidacin mesylate hydrate
Brand: MedChemExpress
SKU: HY-16742B
Rating: 5.0 (8 reviews)

Cat. No.: HY-16742B Purity: 99.45%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Gepotidacin mesylate hydrate is an orally active triazaacenaphthylene antibiotic and bacterial type II topoisomerase inhibitor. Gepotidacin mesylate hydrate inhibits bacterial DNA replication by blocking topoisomerase enzymes. Gepotidacin mesylate hydrate selectively inhibits topoisomerase IV and the B subunit of DNA gyrase.

For research use only. We do not sell to patients.

Gepotidacin mesylate hydrate Chemical Structure

CAS No. : 1624306-20-2

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 8 publication(s) in Google Scholar

Other Forms of Gepotidacin mesylate hydrate:

Gepotidacin (S enantiomer) In-stock
Gepotidacin In-stock

8 Publications Citing Use of MCE Gepotidacin mesylate hydrate

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View All Topoisomerase Isoform Specific Products:

View All Isoforms

Topoisomerase Topo I Topo II

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Gepotidacin is a potent inhibitor of gyrase-catalyzed DNA supercoiling (IC50 ≈ 0.047 μM) and relaxation of positively supercoiled substrates (IC50 ≈ 0.6 μM)^[1].
The MIC of Gepotidacin for E. coli isolates in Mueller-Hinton broth ranged from 1 to 4 mg/L^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

580.65

Formula

C₂₅H₃₆N₆O₈S

CAS No.

1624306-20-2

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C=NC(C=C1)=C23)N3[C@H](CN4CCC(NCC5=CC(CCCO6)=C6C=N5)CC4)CN2C1=O.CS(=O)(O)=O.O.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (430.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7222 mL	8.6110 mL	17.2221 mL
5 mM	0.3444 mL	1.7222 mL	3.4444 mL
10 mM	0.1722 mL	0.8611 mL	1.7222 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.45%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (250 KB) HNMR (284 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Gibson EG, et al. Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase. ACS Infect Dis. 2019 Apr 12;5(4):570-581. [Content Brief]

[2]. Watkins RR, et al. Gepotidacin: a novel, oral, 'first-in-class' triazaacenaphthylene antibiotic for the treatment of uncomplicated urinary tract infections and urogenital gonorrhoea. J Antimicrob Chemother. 2023 May 3;78(5):1137-1142. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7222 mL	8.6110 mL	17.2221 mL	43.0552 mL
	5 mM	0.3444 mL	1.7222 mL	3.4444 mL	8.6110 mL
	10 mM	0.1722 mL	0.8611 mL	1.7222 mL	4.3055 mL
	15 mM	0.1148 mL	0.5741 mL	1.1481 mL	2.8703 mL
	20 mM	0.0861 mL	0.4306 mL	0.8611 mL	2.1528 mL
	25 mM	0.0689 mL	0.3444 mL	0.6889 mL	1.7222 mL
	30 mM	0.0574 mL	0.2870 mL	0.5741 mL	1.4352 mL
	40 mM	0.0431 mL	0.2153 mL	0.4306 mL	1.0764 mL
	50 mM	0.0344 mL	0.1722 mL	0.3444 mL	0.8611 mL
	60 mM	0.0287 mL	0.1435 mL	0.2870 mL	0.7176 mL
	80 mM	0.0215 mL	0.1076 mL	0.2153 mL	0.5382 mL
	100 mM	0.0172 mL	0.0861 mL	0.1722 mL	0.4306 mL