2. Metabolic Enzyme/Protease
  3. PAI-1 Ser/Thr Protease
  4. GGACK

GGACK (H-Glu-Gly-Arg-CMK) is an irreversible substrate-like serine protease urokinase-type plasminogen activator (uPA) inhibitor.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

GGACK Chemical Structure

GGACK Chemical Structure

CAS No. : 65113-67-9

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Based on 1 publication(s) in Google Scholar

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Description

GGACK (H-Glu-Gly-Arg-CMK) is an irreversible substrate-like serine protease urokinase-type plasminogen activator (uPA) inhibitor[1].

Molecular Weight

392.84

Formula

C14H25ClN6O5
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Glu-Gly-Arg-{CMK}
Sequence Shortening

EGR-{CMK}
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (254.56 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5456 mL 12.7278 mL 25.4557 mL
5 mM 0.5091 mL 2.5456 mL 5.0911 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 97.36%

SDS (252 KB)

COA (245 KB) RP-HPLC (111 KB) MS (257 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5456 mL 12.7278 mL 25.4557 mL 63.6391 mL
5 mM 0.5091 mL 2.5456 mL 5.0911 mL 12.7278 mL
10 mM 0.2546 mL 1.2728 mL 2.5456 mL 6.3639 mL
15 mM 0.1697 mL 0.8485 mL 1.6970 mL 4.2426 mL
20 mM 0.1273 mL 0.6364 mL 1.2728 mL 3.1820 mL
25 mM 0.1018 mL 0.5091 mL 1.0182 mL 2.5456 mL
30 mM 0.0849 mL 0.4243 mL 0.8485 mL 2.1213 mL
40 mM 0.0636 mL 0.3182 mL 0.6364 mL 1.5910 mL
50 mM 0.0509 mL 0.2546 mL 0.5091 mL 1.2728 mL
60 mM 0.0424 mL 0.2121 mL 0.4243 mL 1.0607 mL
80 mM 0.0318 mL 0.1591 mL 0.3182 mL 0.7955 mL
100 mM 0.0255 mL 0.1273 mL 0.2546 mL 0.6364 mL
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GGACK Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GGACK65113-67-9PAI-1Ser/Thr ProteasePlasminogen activator inhibitor-1Serine proteasesSerine endopeptidasesThreonine proteasesuPA inhibitorirreversibleInhibitorinhibitorinhibit

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