(S)-S007-1558 (Synonyms: GPVI antagonist 1)

Cat. No.: HY-144390 Purity: 99.78%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

(S)-S007-1558 (compound 5) is a glycoprotein VI (GPVI) platelet receptor antagonist. (S)-S007-1558 inhibits collagen-induced platelet aggregation with an IC₅₀ of 25.3 μM.

For research use only. We do not sell to patients.

(S)-S007-1558 Chemical Structure

CAS No. : 1327156-14-8

Size	Price	Stock	Quantity
5 mg	USD 230	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 365	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 725	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1160	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1850	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Description

(S)-S007-1558 (compound 5) is a glycoprotein VI (GPVI) platelet receptor antagonist. (S)-S007-1558 inhibits collagen-induced platelet aggregation with an IC₅₀ of 25.3 μM^[1].

Molecular Weight

385.44

Formula

C₁₉H₁₉N₃O₄S

CAS No.

1327156-14-8

Appearance

Solid

Color

White to off-white

SMILES

O=C([C@@H]1CC2=C(CN1S(=O)(C3=CC=C(OC)C=C3)=O)NC4=C2C=CC=C4)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 50 mg/mL (129.72 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5944 mL	12.9722 mL	25.9444 mL
5 mM	0.5189 mL	2.5944 mL	5.1889 mL
10 mM	0.2594 mL	1.2972 mL	2.5944 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.78%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (252 KB) HNMR (260 KB) LCMS (92 KB)

Handling Instructions (2659 KB)

References

[1]. Holly Foster, et al. A Comparative Assessment Study of Known Small-molecule GPVI Modulators. ACS Med Chem Lett. 2022 Jan 20;13(2):171-181. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5944 mL	12.9722 mL	25.9444 mL	64.8609 mL
	5 mM	0.5189 mL	2.5944 mL	5.1889 mL	12.9722 mL
	10 mM	0.2594 mL	1.2972 mL	2.5944 mL	6.4861 mL
	15 mM	0.1730 mL	0.8648 mL	1.7296 mL	4.3241 mL
	20 mM	0.1297 mL	0.6486 mL	1.2972 mL	3.2430 mL
	25 mM	0.1038 mL	0.5189 mL	1.0378 mL	2.5944 mL
	30 mM	0.0865 mL	0.4324 mL	0.8648 mL	2.1620 mL
	40 mM	0.0649 mL	0.3243 mL	0.6486 mL	1.6215 mL
	50 mM	0.0519 mL	0.2594 mL	0.5189 mL	1.2972 mL
	60 mM	0.0432 mL	0.2162 mL	0.4324 mL	1.0810 mL
	80 mM	0.0324 mL	0.1622 mL	0.3243 mL	0.8108 mL
	100 mM	0.0259 mL	0.1297 mL	0.2594 mL	0.6486 mL

(S)-S007-1558 Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-S007-15581327156-14-8GPVI antagonist 1GPVI antagonist1GPVI antagonist-1Glycoprotein VIGPVIthrombosisplatelet aggregationInhibitorinhibitorinhibit

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