2. GPCR/G Protein
  3. G Protein-coupled Receptor Kinase (GRK)
  4. GRK6-IN-2

GRK6-IN-2 (compound 10a) is a potent inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 of 120 nM. GRK6 is a critical kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-2 has the potential for the research of multiple myeloma.

For research use only. We do not sell to patients.

GRK6-IN-2 Chemical Structure

GRK6-IN-2 Chemical Structure

CAS No. : 2677786-27-3

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Based on 1 publication(s) in Google Scholar

GRK6-IN-2 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE GRK6-IN-2

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Description

GRK6-IN-2 (compound 10a) is a potent inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 of 120 nM. GRK6 is a critical kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-2 has the potential for the research of multiple myeloma[1].

Molecular Weight

376.43

Formula

C21H21FN6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@H](NC1=NC(NC2=NNC(CC)=C2)=C3C=CC=CC3=N1)C4=CC=C(F)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Methanol : ≥ 125 mg/mL (332.07 mM)

DMSO : ≥ 100 mg/mL (265.65 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6565 mL 13.2827 mL 26.5654 mL
5 mM 0.5313 mL 2.6565 mL 5.3131 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / Methanol 1 mM 2.6565 mL 13.2827 mL 26.5654 mL 66.4134 mL
5 mM 0.5313 mL 2.6565 mL 5.3131 mL 13.2827 mL
10 mM 0.2657 mL 1.3283 mL 2.6565 mL 6.6413 mL
15 mM 0.1771 mL 0.8855 mL 1.7710 mL 4.4276 mL
20 mM 0.1328 mL 0.6641 mL 1.3283 mL 3.3207 mL
25 mM 0.1063 mL 0.5313 mL 1.0626 mL 2.6565 mL
30 mM 0.0886 mL 0.4428 mL 0.8855 mL 2.2138 mL
40 mM 0.0664 mL 0.3321 mL 0.6641 mL 1.6603 mL
50 mM 0.0531 mL 0.2657 mL 0.5313 mL 1.3283 mL
60 mM 0.0443 mL 0.2214 mL 0.4428 mL 1.1069 mL
80 mM 0.0332 mL 0.1660 mL 0.3321 mL 0.8302 mL
100 mM 0.0266 mL 0.1328 mL 0.2657 mL 0.6641 mL
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GRK6-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GRK6-IN-22677786-27-3G Protein-coupled Receptor Kinase (GRK)GRK6multiple myelomasurvivalInhibitorinhibitorinhibit

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