2. Membrane Transporter/Ion Channel
  3. P2X Receptor
  4. GSK-1482160

GSK-1482160 is an orally available negative allosteric modulator of the P2X7 receptor. P2X7 receptors are involved in the production of pro-inflammatory cytokines, such as Il-1β, by central and peripheral immune cells. GSK-1482160 has the potential for the research of inflammation diseases.

For research use only. We do not sell to patients.

GSK-1482160 Chemical Structure

GSK-1482160 Chemical Structure

CAS No. : 1001389-72-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 110 In-stock
Solution
10 mM * 1 mL in DMSO USD 110 In-stock
Solid
5 mg USD 100 In-stock
10 mg USD 160 In-stock
25 mg USD 320 In-stock
50 mg USD 560 In-stock
100 mg USD 980 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of GSK-1482160:

GSK-1482160 Related Antibodies

Top Publications Citing Use of Products

View All P2X Receptor Isoform Specific Products:

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P2X1 Receptor P2X2 Receptor P2X3 Receptor P2X4 Receptor P2X7 Receptor

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Description

GSK-1482160 is an orally available negative allosteric modulator of the P2X7 receptor. P2X7 receptors are involved in the production of pro-inflammatory cytokines, such as Il-1β, by central and peripheral immune cells. GSK-1482160 has the potential for the research of inflammation diseases[1].

IC50 & Target

P2X7 Receptor

 

Clinical Trial
Molecular Weight

334.72

Formula

C14H14ClF3N2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H](CC1)N(C)C1=O)NCC2=CC=CC(C(F)(F)F)=C2Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (298.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9876 mL 14.9379 mL 29.8757 mL
5 mM 0.5975 mL 2.9876 mL 5.9751 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9876 mL 14.9379 mL 29.8757 mL 74.6893 mL
5 mM 0.5975 mL 2.9876 mL 5.9751 mL 14.9379 mL
10 mM 0.2988 mL 1.4938 mL 2.9876 mL 7.4689 mL
15 mM 0.1992 mL 0.9959 mL 1.9917 mL 4.9793 mL
20 mM 0.1494 mL 0.7469 mL 1.4938 mL 3.7345 mL
25 mM 0.1195 mL 0.5975 mL 1.1950 mL 2.9876 mL
30 mM 0.0996 mL 0.4979 mL 0.9959 mL 2.4896 mL
40 mM 0.0747 mL 0.3734 mL 0.7469 mL 1.8672 mL
50 mM 0.0598 mL 0.2988 mL 0.5975 mL 1.4938 mL
60 mM 0.0498 mL 0.2490 mL 0.4979 mL 1.2448 mL
80 mM 0.0373 mL 0.1867 mL 0.3734 mL 0.9336 mL
100 mM 0.0299 mL 0.1494 mL 0.2988 mL 0.7469 mL
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GSK-1482160 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK-14821601001389-72-5GSK1482160GSK 1482160P2X ReceptorP2XRsorallyP2X7 receptorspro-inflammatoryIl-1βperipheralinflammationInhibitorinhibitorinhibit

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