2. PI3K/Akt/mTOR Stem Cell/Wnt
  3. GSK-3
  4. GSK-3β inhibitor 12

GSK-3β inhibitor 12 (compound 15) is an inhibitor of GSK-3β. GSK-3β inhibitor 12 inhibits 49.11% and 37.11% activity of 25 μM and 50 μM GSK-3β, respectively. GSK-3β inhibitor 12 can be used for the research of neurodegenerative diseases.

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GSK-3β inhibitor 12 Chemical Structure

GSK-3β inhibitor 12 Chemical Structure

CAS No. : 784170-07-6

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10 mg USD 320 In-stock
25 mg USD 550 In-stock
50 mg USD 785 In-stock
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Description

GSK-3β inhibitor 12 (compound 15) is an inhibitor of GSK-3β. GSK-3β inhibitor 12 inhibits 49.11% and 37.11% activity of 25 μM and 50 μM GSK-3β, respectively. GSK-3β inhibitor 12 can be used for the research of neurodegenerative diseases[1].

Molecular Weight

271.34

Formula

C14H13N3OS
CAS No.
Appearance

Solid

Color

Light brown to brown

SMILES

O=C(CC1=CNC2=C1C=CC=C2)NC3=NC=C(C)S3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (460.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6854 mL 18.4271 mL 36.8541 mL
5 mM 0.7371 mL 3.6854 mL 7.3708 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6854 mL 18.4271 mL 36.8541 mL 92.1353 mL
5 mM 0.7371 mL 3.6854 mL 7.3708 mL 18.4271 mL
10 mM 0.3685 mL 1.8427 mL 3.6854 mL 9.2135 mL
15 mM 0.2457 mL 1.2285 mL 2.4569 mL 6.1424 mL
20 mM 0.1843 mL 0.9214 mL 1.8427 mL 4.6068 mL
25 mM 0.1474 mL 0.7371 mL 1.4742 mL 3.6854 mL
30 mM 0.1228 mL 0.6142 mL 1.2285 mL 3.0712 mL
40 mM 0.0921 mL 0.4607 mL 0.9214 mL 2.3034 mL
50 mM 0.0737 mL 0.3685 mL 0.7371 mL 1.8427 mL
60 mM 0.0614 mL 0.3071 mL 0.6142 mL 1.5356 mL
80 mM 0.0461 mL 0.2303 mL 0.4607 mL 1.1517 mL
100 mM 0.0369 mL 0.1843 mL 0.3685 mL 0.9214 mL
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GSK-3β inhibitor 12 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK-3β inhibitor 12784170-07-6GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3N-(2-Thiazolyl)-amidederivativeAlzheimer’s diseasenon-insulin dependent diabetes mellituspharmaceutical compositionInhibitorinhibitorinhibit

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