2. Metabolic Enzyme/Protease
  3. Phospholipase
  4. GSK2647544

GSK2647544 is an orally available, selective inhibitor of Lp-PLA2. Lipoprotein-associated phospholipase (Lp-PLA2) is a calcium-independent phospholipase A2 with proinflammatory activities that is primarily secreted by monocyte-derived macrophages.

For research use only. We do not sell to patients.

GSK2647544 Chemical Structure

GSK2647544 Chemical Structure

CAS No. : 1380426-95-8

Size Price Stock Quantity
5 mg USD 450 In-stock
10 mg USD 800 In-stock
25 mg USD 1650 In-stock
50 mg USD 2550 In-stock
100 mg USD 3400 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

GSK2647544 is an orally available, selective inhibitor of Lp-PLA2. Lipoprotein-associated phospholipase (Lp-PLA2) is a calcium-independent phospholipase A2 with proinflammatory activities that is primarily secreted by monocyte-derived macrophages[1].

Clinical Trial
Molecular Weight

502.87

Formula

C24H18ClF3N4O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NC(OCCC2=CC=C(C=C2)OC3=CC=C(C(C(F)(F)F)=C3)Cl)=NC=C1CC4=CN=CN=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (198.86 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9886 mL 9.9429 mL 19.8859 mL
5 mM 0.3977 mL 1.9886 mL 3.9772 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.46%

SDS (251 KB)

COA (244 KB) HNMR (220 KB) LCMS (156 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9886 mL 9.9429 mL 19.8859 mL 49.7146 mL
5 mM 0.3977 mL 1.9886 mL 3.9772 mL 9.9429 mL
10 mM 0.1989 mL 0.9943 mL 1.9886 mL 4.9715 mL
15 mM 0.1326 mL 0.6629 mL 1.3257 mL 3.3143 mL
20 mM 0.0994 mL 0.4971 mL 0.9943 mL 2.4857 mL
25 mM 0.0795 mL 0.3977 mL 0.7954 mL 1.9886 mL
30 mM 0.0663 mL 0.3314 mL 0.6629 mL 1.6572 mL
40 mM 0.0497 mL 0.2486 mL 0.4971 mL 1.2429 mL
50 mM 0.0398 mL 0.1989 mL 0.3977 mL 0.9943 mL
60 mM 0.0331 mL 0.1657 mL 0.3314 mL 0.8286 mL
80 mM 0.0249 mL 0.1243 mL 0.2486 mL 0.6214 mL
100 mM 0.0199 mL 0.0994 mL 0.1989 mL 0.4971 mL
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GSK2647544 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK26475441380426-95-8GSK 2647544GSK-2647544PhospholipaseAlzheimer’s diseaseproinflammatorycardiovascularLp-PLA2oralInhibitorinhibitorinhibit

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