HA-CD44 interaction inhibitor 1

Name: HA-CD44 interaction inhibitor 1
Brand: MedChemExpress
SKU: HY-149898
Rating: 4.5 (1 reviews)

Cat. No.: HY-149898 Purity: 98.93%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Antitumor agent-109 (compound 6) is an inhibitor of hyaluronic acid (HY-B0633A) targeting to CD44, as well as an anti-tumor agent. Hyaluronic acid interacts with differentiation cluster 44 (CD44) and is involved in tumor growth and invasion. Antitumor agent-109 inhibits MDA-MB-231 cells with EC50 value of 0.59 μM.

For research use only. We do not sell to patients.

HA-CD44 interaction inhibitor 1 Chemical Structure

CAS No. : 3052354-70-5

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 280	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 280	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 255	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 385	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 693	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1040	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1560	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

Hyaluronic acid

Molecular Weight

392.29

Formula

C₁₉H₂₂BrNO₃

CAS No.

3052354-70-5

Appearance

Solid

Color

White to off-white

SMILES

COC1=C(OC)C(OC)=CC(CN2CC3=C(C(Br)=CC=C3)CC2)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (254.91 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5491 mL	12.7457 mL	25.4913 mL
5 mM	0.5098 mL	2.5491 mL	5.0983 mL
10 mM	0.2549 mL	1.2746 mL	2.5491 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (12.75 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (12.75 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.93%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (248 KB) HNMR (149 KB) RP-HPLC (173 KB) LCMS (117 KB)

Handling Instructions (2659 KB)

References

[1]. Espejo-Román JM, et al. N-aryltetrahydroisoquinoline derivatives as HA-CD44 interaction inhibitors: Design, synthesis, computational studies, and antitumor effect. Eur J Med Chem. 2023 Oct 5;258:115570. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5491 mL	12.7457 mL	25.4913 mL	63.7284 mL
	5 mM	0.5098 mL	2.5491 mL	5.0983 mL	12.7457 mL
	10 mM	0.2549 mL	1.2746 mL	2.5491 mL	6.3728 mL
	15 mM	0.1699 mL	0.8497 mL	1.6994 mL	4.2486 mL
	20 mM	0.1275 mL	0.6373 mL	1.2746 mL	3.1864 mL
	25 mM	0.1020 mL	0.5098 mL	1.0197 mL	2.5491 mL
	30 mM	0.0850 mL	0.4249 mL	0.8497 mL	2.1243 mL
	40 mM	0.0637 mL	0.3186 mL	0.6373 mL	1.5932 mL
	50 mM	0.0510 mL	0.2549 mL	0.5098 mL	1.2746 mL
	60 mM	0.0425 mL	0.2124 mL	0.4249 mL	1.0621 mL
	80 mM	0.0319 mL	0.1593 mL	0.3186 mL	0.7966 mL
	100 mM	0.0255 mL	0.1275 mL	0.2549 mL	0.6373 mL