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  3. Bacterial Antibiotic
  4. Hexahydrofarnesyl acetone

Hexahydrofarnesyl acetone  (Synonyms: 6,10,14-Trimethyl-2-pentadecanone)

Cat. No.: HY-N3074 Purity: 99.25%
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Hexahydrofarnesyl acetone (6,10,14-Trimethyl-2-pentadecanone) is a oral active sesquiterpene with oral activity, exhibiting antibacterial, anti-inflammatory, and anticancer properties, and is used in pain relief research.

For research use only. We do not sell to patients.

Hexahydrofarnesyl acetone Chemical Structure

Hexahydrofarnesyl acetone Chemical Structure

CAS No. : 502-69-2

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5 mg USD 32 In-stock
10 mg USD 50 In-stock
25 mg USD 95 In-stock
100 mg USD 200 In-stock
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Based on 1 publication(s) in Google Scholar

Hexahydrofarnesyl acetone Related Antibodies

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  • Purity & Documentation

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Description

Hexahydrofarnesyl acetone (6,10,14-Trimethyl-2-pentadecanone) is a oral active sesquiterpene with oral activity, exhibiting antibacterial, anti-inflammatory, and anticancer properties, and is used in pain relief research[1][2][3].

In Vitro

The essential oil of Lindera nacusua (containing 6.83% Hexahydrofarnesyl acetone, 0.2 mg of essential oil, 0.1 mL microbial suspension, 24 hours) exhibits significant antibacterial activity against Staphylococcus aureus and Candida albicans, with inhibition zones reaching 2.5 mm and 2.0 mm, respectively, surpassing the positive control, Amoxicillin (HY-B0467A)[2].
The essential oil of Graptophyllum pictum (containing 2.6% Hexahydrofarnesyl acetone, 5 μL of essential oil, 3, 4, or 5 days) shows significant cytotoxicity against KB cells (epidermoid carcinoma of oral cavity), NCI-H187 cells (small cell lung carcinoma), and Vero cells (African green monkey kidney)[2]。

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hexahydrofarnesyl acetone Related Antibodies

Cell Cytotoxicity Assay[3]

Cell Line: KB cells (epidermoid carcinoma oforal cavity), MCF-7 cells (breast adenocarcinoma), NCI-H187 cells (small cell lung carcinoma) and Vero cells (the African green monkey kidney)
Concentration: 5 μL (administered as essential oil containing 2.6% Hexahydrofarnesyl acetone)
Incubation Time: 3 (KB and MCF-7 cells), 4 (Vero cells) or 5 (NCI-H187 cells) days
Result: Had the IC50 values of 27.04, 25.27, and 26.52 µg/mL against KB cells, NCI-H187 cells, and Vero cells, respectively.
In Vivo

The essential oil of Albizia zygia (containing 33.14% Hexahydrofarnesyl acetone, 100, 200, 400 mg/kg, p.o., single dose) inhibits carrageenan (HY-125474)-induced inflammation in the paw edema model of Wistar rats[1].
The essential oil of Albizia zygia (containing 33.14% Hexahydrofarnesyl acetone, 100, 200, 400 mg/kg, p.o., single dose) exhibits analgesic effects in the formalin-induced pain model in Wistar rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Carrageenan (HY-125474)-induced paw edema model in Wistar rats (150-200 g)[1]
Dosage: 100, 200, 400 mg/kg
Administration: Oral gavage (p.o.), single dose
Result: Exerted a significant dose-dependent inhibitory effect on the development of carrageenan (HY-125474)-induced paw swelling.
Animal Model: Formalin-induced pain model in Wistar rats (150-200 g)[1]
Dosage: 100, 200, 400 mg/kg
Administration: Oral gavage (p.o.), single dose
Result: Increased the tolerance of rats to Formalin-induced pain.
Molecular Weight

268.48

Formula

C18H36O
CAS No.
Appearance

Liquid (Density: 0.8403 g/cm3)

Color

Colorless to light yellow

SMILES

CC(CCCC(C)CCCC(C)CCCC(C)C)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (124.14 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7247 mL 18.6234 mL 37.2467 mL
5 mM 0.7449 mL 3.7247 mL 7.4493 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (9.31 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (9.31 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.25%

COA (239 KB) HNMR (233 KB) GC (269 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7247 mL 18.6234 mL 37.2467 mL 93.1168 mL
5 mM 0.7449 mL 3.7247 mL 7.4493 mL 18.6234 mL
10 mM 0.3725 mL 1.8623 mL 3.7247 mL 9.3117 mL
15 mM 0.2483 mL 1.2416 mL 2.4831 mL 6.2078 mL
20 mM 0.1862 mL 0.9312 mL 1.8623 mL 4.6558 mL
25 mM 0.1490 mL 0.7449 mL 1.4899 mL 3.7247 mL
30 mM 0.1242 mL 0.6208 mL 1.2416 mL 3.1039 mL
40 mM 0.0931 mL 0.4656 mL 0.9312 mL 2.3279 mL
50 mM 0.0745 mL 0.3725 mL 0.7449 mL 1.8623 mL
60 mM 0.0621 mL 0.3104 mL 0.6208 mL 1.5519 mL
80 mM 0.0466 mL 0.2328 mL 0.4656 mL 1.1640 mL
100 mM 0.0372 mL 0.1862 mL 0.3725 mL 0.9312 mL
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Hexahydrofarnesyl acetone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hexahydrofarnesyl acetone502-69-26,10,14-Trimethyl-2-pentadecanoneBacterialAntibioticantibacterialanti-nociceptiveanti-inflammationSesquiterpeneInhibitorinhibitorinhibit

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