2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. HMR 1556

HMR 1556, un dérivé du chromanol, est un bloqueur puissant de IKs avec des IC50s de 10,5 nM et 34 nM dans les myocytes ventriculaires gauches du chien et du cobaye, respectivement.

HMR 1556, a chromanol derivative, is a potent IKs blocker with IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively.

For research use only. We do not sell to patients.

HMR 1556 Chemical Structure

HMR 1556 Chemical Structure

CAS No. : 223749-46-0

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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Solution
10 mM * 1 mL in DMSO USD 165 In-stock
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5 mg USD 150 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

HMR 1556 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE HMR 1556

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

HMR 1556, a chromanol derivative, is a potent IKs blocker with IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively[1][2].

IC50 & Target

IC50: 10.5 nM (IKs in canine left ventricular myocytes), 34 nM (IKs in guinea pig left ventricular myocytes)[1]
In Vitro

HMR 1556 inhibits Ito, ICa,L and IKr with IC50s of 33.9 μM, 27.5 μM, 12.6 μM in canine left ventricular myocytes, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HMR 1556 Related Antibodies
Molecular Weight

411.44

Formula

C17H24F3NO5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CS(N([C@H]1C2=CC(OCCCC(F)(F)F)=CC=C2OC(C)(C)[C@@H]1O)C)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (243.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4305 mL 12.1524 mL 24.3049 mL
5 mM 0.4861 mL 2.4305 mL 4.8610 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 2.5 mg/mL (6.08 mM); Suspended solution; Need ultrasonic

    This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: 2.5 mg/mL (6.08 mM); Suspended solution; Need ultrasonic

    This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.90%

COA (249 KB) LCMS (130 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4305 mL 12.1524 mL 24.3049 mL 60.7622 mL
5 mM 0.4861 mL 2.4305 mL 4.8610 mL 12.1524 mL
10 mM 0.2430 mL 1.2152 mL 2.4305 mL 6.0762 mL
15 mM 0.1620 mL 0.8102 mL 1.6203 mL 4.0508 mL
20 mM 0.1215 mL 0.6076 mL 1.2152 mL 3.0381 mL
25 mM 0.0972 mL 0.4861 mL 0.9722 mL 2.4305 mL
30 mM 0.0810 mL 0.4051 mL 0.8102 mL 2.0254 mL
40 mM 0.0608 mL 0.3038 mL 0.6076 mL 1.5191 mL
50 mM 0.0486 mL 0.2430 mL 0.4861 mL 1.2152 mL
60 mM 0.0405 mL 0.2025 mL 0.4051 mL 1.0127 mL
80 mM 0.0304 mL 0.1519 mL 0.3038 mL 0.7595 mL
100 mM 0.0243 mL 0.1215 mL 0.2430 mL 0.6076 mL
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HMR 1556 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HMR 1556223749-46-0HMR1556HMR-1556Potassium ChannelKcsAInhibitorinhibitorinhibit

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