2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease
  4. HZ1

Anticancer agent 241 (HZ1) is an orally active first-in-class cyclin-dependent kinase like 3 (CDKL3)-specific inhibitor. Anticancer agent 241 shows a strong tumor-suppressing effect, and has the potential to overcome the resistance of CDK4/6 inhibitor.

For research use only. We do not sell to patients.

HZ1 Chemical Structure

HZ1 Chemical Structure

CAS No. : 3030492-40-8

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

HZ1 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Anticancer agent 241 (HZ1) is an orally active first-in-class cyclin-dependent kinase like 3 (CDKL3)-specific inhibitor. Anticancer agent 241 shows a strong tumor-suppressing effect, and has the potential to overcome the resistance of CDK4/6 inhibitor[1].

In Vitro

Anticancer agent 241 (HZ1; 2-10 h; 100 nM) markedly decreases the levels of pRb and CDK4 hence effectively triggering cell cycle arrest and tumor death[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HZ1 Related Antibodies

Western Blot Analysis[1]

Cell Line: DLD-1 cells
Concentration: 100 nM
Incubation Time: 2 h, 4 h, 6 h, 8 h, 10 h
Result: Reduced the levels of pRb and CDK4.
In Vivo

Anticancer agent 241 (HZ1; 1 mg/kg; oral gavage; daily for 12-14 days) has anticancer activity in a mouse model of colon cancer[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week-old female athymic nude mice injected with DLD-1 cells[1]
Dosage: 1 mg/kg
Administration: Oral gavage; daily for 12-14 days
Result: Suppressed tumor volume in a mouse model of colon cancer.
Molecular Weight

362.43

Formula

C20H22N6O
CAS No.
SMILES

O=C(C)C(C=C1)=CC=C1NC2=NC(NC3=CC(C4CCCC4)=NN3)=CC=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

HZ1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HZ13030492-40-8HZ 1HZ-1Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesCDKL3 InhibitorAnticancer agentcell cycleorally activeInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
HZ1
Cat. No.:
HY-161847
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.