2. Others Apoptosis
  3. Others MDM-2/p53
  4. Idasanutlin (enantiomer)

Idasanutlin (enantiomer)  (Synonyms: RG7388 (enantiomer))

Cat. No.: HY-15676A Purity: 99.18%
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Idasanutlin enantiomer is the isomer of Idasanutlin (HY-15676), and can be used as an experimental control. Idasanutlin (RG7388) is a potent and selective MDM2 antagonist, inhibiting p53-MDM2 binding, with an IC50 of 6 nM.

For research use only. We do not sell to patients.

Idasanutlin (enantiomer) Chemical Structure

Idasanutlin (enantiomer) Chemical Structure

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Based on 1 publication(s) in Google Scholar

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Idasanutlin (enantiomer) Related Antibodies

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Description

Idasanutlin enantiomer is the isomer of Idasanutlin (HY-15676), and can be used as an experimental control. Idasanutlin (RG7388) is a potent and selective MDM2 antagonist, inhibiting p53-MDM2 binding, with an IC50 of 6 nM.

Molecular Weight

616.48

Formula

C31H29Cl2F2N3O4
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H]1N[C@H](CC(C)(C)C)[C@](C2=CC=C(Cl)C=C2F)(C#N)[C@@H]1C3=CC=CC(Cl)=C3F)NC4=C(OC)C=C(C(O)=O)C=C4
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (162.21 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6221 mL 8.1106 mL 16.2211 mL
5 mM 0.3244 mL 1.6221 mL 3.2442 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6221 mL 8.1106 mL 16.2211 mL 40.5528 mL
5 mM 0.3244 mL 1.6221 mL 3.2442 mL 8.1106 mL
10 mM 0.1622 mL 0.8111 mL 1.6221 mL 4.0553 mL
15 mM 0.1081 mL 0.5407 mL 1.0814 mL 2.7035 mL
20 mM 0.0811 mL 0.4055 mL 0.8111 mL 2.0276 mL
25 mM 0.0649 mL 0.3244 mL 0.6488 mL 1.6221 mL
30 mM 0.0541 mL 0.2704 mL 0.5407 mL 1.3518 mL
40 mM 0.0406 mL 0.2028 mL 0.4055 mL 1.0138 mL
50 mM 0.0324 mL 0.1622 mL 0.3244 mL 0.8111 mL
60 mM 0.0270 mL 0.1352 mL 0.2704 mL 0.6759 mL
80 mM 0.0203 mL 0.1014 mL 0.2028 mL 0.5069 mL
100 mM 0.0162 mL 0.0811 mL 0.1622 mL 0.4055 mL
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Idasanutlin (enantiomer) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Idasanutlin (enantiomer)RG7388 (enantiomer)OthersMDM-2/p53Inhibitorinhibitorinhibit

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