iNOs-IN-1 

iNOs-IN-1 (YPW) is a potent inducible nitric oxide synthase (iNOS) inhibitor. iNOs-IN-1 can significantly inhibit the expression of IL-6 and iNOS, as well as reduce LPS-induced NO generation with dose-dependent manner in mouse macrophages. Anti-inflammatory effects^[1].

iNOs-IN-1 (YPW) (12.5, 25 and 50 µM; 2 hours) can significantly reduce NO production in LPS-treated RAW 264.7 cells^[1].
iNOs-IN-1 (12.5, 25 and 50 µM; 2 hours) inhibits IL-6 production and iNOS protein expression in LPS-treated RAW 264.7 mouse macrophages^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

464.51

C₂₅H₂₈N₄O₅

Solid

White to off-white

N[C@@H](C(N1CCC[C@H]1C(N[C@H](C(O)=O)CC2=CNC3=C2C=CC=C3)=O)=O)CC4=CC=C(C=C4)O

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Peng Y, et al. Identification and molecular mechanism of a tri-peptide inhibitor targeting iNOS from duck embryo protein hydrolysates by experimental and bioinformatics studies. Bioorg Chem. 2022;122:105736.  [Content Brief]