Itraconazole-d₃ (Synonyms: R51211-d₃)

Cat. No.: HY-17514S1 Purity: 99.62%: FAQs
Data Sheet SDS COA Handling Instructions

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Itraconazole-d₃ is the deuterium labeled Itraconazole (HY-17514)[1].

For research use only. We do not sell to patients.

Itraconazole-d<sub>3</sub> Chemical Structure

Itraconazole-d₃ Chemical Structure

CAS No. : 1217512-35-0

Size	Price	Stock	Quantity
1 mg	USD 390	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 990	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1600	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Itraconazole-d₃:

Itraconazole In-stock

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

Biological Activity
Purity & Documentation
References
Customer Review

Description

Itraconazole-d₃ is the deuterium labeled Itraconazole (HY-17514)[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 30 μM Compound: ITC	Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 34388384]
A549	IC₅₀	> 50 μM Compound: 2; ILC	Cytotoxicity against human A549 cells assessed as inhibition of cell growth incubated for 4 hrs by MTT assay Cytotoxicity against human A549 cells assessed as inhibition of cell growth incubated for 4 hrs by MTT assay	[PMID: 34749201]
A549	IC₅₀	182 μg/mL Compound: IT	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 24513049]
A549	IC₅₀	3 μM Compound: Itraconazole	Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 36184028]
C3H 10T1/2	IC₅₀	0.063 μM Compound: 1; ITZ	Inhibition of hedgehog pathway in mouse C3H10T1/2 cells assessed as downregulation of Gli1 mRNA expression after 24 hrs by qPCR method Inhibition of hedgehog pathway in mouse C3H10T1/2 cells assessed as downregulation of Gli1 mRNA expression after 24 hrs by qPCR method	[PMID: 27014922]
CHO	IC₅₀	> 40 μM Compound: 2	Inhibition of human ERG expressed in CHO cells by whole-cell patch clamp assay Inhibition of human ERG expressed in CHO cells by whole-cell patch clamp assay	[PMID: 24564525]
HEK293	IC₅₀	> 250 μM Compound: Itraconazole	Cytotoxicity against human HEK293 cells after 72 hrs by MTT assay Cytotoxicity against human HEK293 cells after 72 hrs by MTT assay	[PMID: 29626797]
HEK-293T	IC₅₀	> 50 μM Compound: 2; ILC	Cytotoxicity against human HEK293T cells assessed as inhibition of cell growth incubated for 4 hrs by MTT assay Cytotoxicity against human HEK293T cells assessed as inhibition of cell growth incubated for 4 hrs by MTT assay	[PMID: 34749201]
Hepatocyte	IC₅₀	0.07 μM Compound: Itraconazole	Inhibition of CYP3A4 in human hepatocytes using testosterone as substrate by HPLC/MS/MS method Inhibition of CYP3A4 in human hepatocytes using testosterone as substrate by HPLC/MS/MS method	[PMID: 24948565]
HepG2	IC₅₀	> 50 μM Compound: 2; ILC	Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 4 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 4 hrs by MTT assay	[PMID: 34749201]
HepG2	IC₅₀	142 μg/mL Compound: IT	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 24513049]
HepG2	IC₅₀	7.87 μM Compound: Itraconazole	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 36184028]
HT-1080	IC₅₀	201.63 μg/mL Compound: IT	Cytotoxicity against human HT1080 cells after 48 hrs by MTT assay Cytotoxicity against human HT1080 cells after 48 hrs by MTT assay	[PMID: 24513049]
HUVEC	IC₅₀	0.17 μM Compound: 1	Anti-angiogenic activity against HUVEC after 24 hrs by scintillation counting based [3H]-thymidine incorporation assay Anti-angiogenic activity against HUVEC after 24 hrs by scintillation counting based [3H]-thymidine incorporation assay	[PMID: 30481027]
HUVEC	GI₅₀	0.4 μM Compound: 1; ITZ	Antiproliferative activity against HUVEC assessed as inhibition of VEGF induced cell proliferation after 72 hrs by MTS assay Antiproliferative activity against HUVEC assessed as inhibition of VEGF induced cell proliferation after 72 hrs by MTS assay	[PMID: 27014922]
HUVEC	IC₅₀	160 nM Compound: 1; ITZ	Antiproliferative activity against HUVEC assessed as inhibition of VEGF induced cell proliferation using methyl-[3H]thymidine after 36 hrs Antiproliferative activity against HUVEC assessed as inhibition of VEGF induced cell proliferation using methyl-[3H]thymidine after 36 hrs	[PMID: 27014922]
HUVEC	IC₅₀	170 nM Compound: 1	Inhibition of NPC1/VDAC1 in HUVEC cells assessed as reduction in cell proliferation pretreated for 24 hrs followed by [3H]thymidine incorporation by scintillation counter method Inhibition of NPC1/VDAC1 in HUVEC cells assessed as reduction in cell proliferation pretreated for 24 hrs followed by [3H]thymidine incorporation by scintillation counter method	[PMID: 32550989]
L02	IC₅₀	> 50 μM Compound: Itraconazole	Cytotoxicity against human L02 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Cytotoxicity against human L02 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 36184028]
LLC-PK1	IC₅₀	0.2 μM Compound: Itraconazole	Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay	[PMID: 12699389]
LLC-PK1	IC₅₀	0.7 μM Compound: Itraconazole	Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay	[PMID: 12699389]
LLC-PK1	IC₅₀	2.1 μM Compound: Itraconazole	Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay	[PMID: 12699389]
MCF-10A	IC₅₀	> 300 μM Compound: IT	Cytotoxicity against human MCF10A cells after 48 hrs by WST1 assay Cytotoxicity against human MCF10A cells after 48 hrs by WST1 assay	[PMID: 24513049]
MCF7	IC₅₀	> 30 μM Compound: ITC	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 34388384]
MCF7	IC₅₀	> 50 μM Compound: 2; ILC	Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 4 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 4 hrs by MTT assay	[PMID: 34749201]
Medulloblastoma cell	GI₅₀	0.44 μM Compound: 1; ITZ	Antiproliferative activity against mouse MERP MB cells assessed as cell growth inhibition using methyl-[3H]thymidine after 48 hrs by liquid scintillation spectrophotometry Antiproliferative activity against mouse MERP MB cells assessed as cell growth inhibition using methyl-[3H]thymidine after 48 hrs by liquid scintillation spectrophotometry	[PMID: 27014922]
PBMC	IC₅₀	1.53 μM Compound: Itraconazole	Cytotoxicity against human PBMC assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against human PBMC assessed as cell viability after 72 hrs by MTT assay	[PMID: 24485783]
THLE-2	IC₅₀	> 30 μM Compound: ITC	Cytotoxicity against human THLE-2 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay Cytotoxicity against human THLE-2 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 34388384]
Vero	IC₅₀	> 50 μg/mL Compound: ITZ	Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay	[PMID: 23831506]

Molecular Weight

708.65

Formula

C₃₅H₃₅D₃Cl₂N₈O₄

CAS No.

1217512-35-0

Unlabeled CAS

84625-61-6

Appearance

Solid

Color

White to off-white

SMILES

O=C(N(N=C1)C(C([2H])([2H])[2H])CC)N1C(C=C2)=CC=C2N(CC3)CCN3C(C=C4)=CC=C4OC[C@@H](CO5)O[C@]5(C6=C(C=C(C=C6)Cl)Cl)CN7C=NC=N7

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMF : ≥ 0.5 mg/mL (0.71 mM)

DMSO : ≥ 0.5 mg/mL (0.71 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : ≥ 0.5 mg/mL (0.71 mM)

*"≥" means soluble, but saturation unknown.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.62%

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Data Sheet (269 KB) SDS (252 KB)

COA (253 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Dwivedi A, et al. Ultra-performance liquid chromatography electrospray ionization-tandem mass spectrometry method for the simultaneous determination of itraconazole and hydroxy itraconazole in human plasma. J Pharm Anal. 2014 Oct;4(5):316-324. [Content Brief]

Itraconazole-d₃ Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Itraconazole-d₃1217512-35-0R51211-d₃FungalAutophagyHedgehogBacterialAntibioticCytochrome P450CYPsInhibitorinhibitorinhibit

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Itraconazole-d3 (Synonyms: R51211-d3)

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Itraconazole-d₃ (Synonyms: R51211-d₃)

Other Forms of Itraconazole-d₃:

Itraconazole-d₃ Related Antibodies

Itraconazole-d₃ Related Classifications