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  4. Ivospemin

Ivospemin (SBP-101) is an antineoplastic spermine analog. Ivospemin has shown efficacy in slowing pancreatic and ovarian tumor progression in vitro and in vivo. Ivospemin shows modest induction of polyamine catabolism, but stronger repression of ornithine decarboxylase activity. Ivospemin is promising for research of cancers.

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Ivospemin Chemical Structure

Ivospemin Chemical Structure

CAS No. : 748119-79-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 683 In-stock
Solution
10 mM * 1 mL in DMSO USD 683 In-stock
Solid
1 mg USD 390 In-stock
5 mg USD 975 In-stock
10 mg USD 1655 In-stock
25 mg USD 3315 In-stock
50 mg USD 5310 In-stock
100 mg USD 8500 In-stock
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Based on 1 publication(s) in Google Scholar

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Ivospemin Related Antibodies

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  • Purity & Documentation

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Description

Ivospemin (SBP-101) is an antineoplastic spermine analog. Ivospemin has shown efficacy in slowing pancreatic and ovarian tumor progression in vitro and in vivo. Ivospemin shows modest induction of polyamine catabolism, but stronger repression of ornithine decarboxylase activity. Ivospemin is promising for research of cancers[1][2][3].

In Vitro

Ivospemin (500 nM to 10 µM, 96 h) reduces cell viability in human ovarian adenocarcinoma cells with IC50 values ranging between 0.95 µM and 3.24 µM regardless of cisplatin sensitivity[2].

IC50 values following Ivospemin treatment in human ovarian adenocarcinoma cell lines[1]

Cell Line CaOV-3 A2780 OV90 ACRP
Ivospemin 96 h IC50 2.56 µM 0.95 µM 3.24 µM 1.41 µM

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ivospemin Related Antibodies

Cell Viability Assay[2]

Cell Line: A2780, OV90, ACRP, and CaOV-3 cell lines
Concentration: 500 nM to 10 µM
Incubation Time: 96 h
Result: Reduced cell viability in A2780, OV90, ACRP, and CaOV-3 cell lines.
In Vivo

Ivospemin (24 mg/kg, i.p., 2qw×3, alternating weeks for 60 days) increases survival by delaying disease onset and decreasing overall tumor burden in a murine ovarian adenocarcinoma model[2][3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Murine Ovarian Adenocarcinoma Model[2][3]
Dosage: 24 mg/kg
Administration: i.p., 2qw×3, alternating weeks for 60 days
Result: Produced a 20% increase in median survival from 43 days to 52 days post-injection, extended the time to ascites formation to 46.9 days, an increase of 13% combined with Gemcitabine (HY-17026) or Topotecan (HY-13768).
Clinical Trial
Molecular Weight

318.50

Formula

C16H38N4O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCNCC[C@H](O)CNCCCCNC[C@@H](O)CCNCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (62.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1397 mL 15.6986 mL 31.3972 mL
5 mM 0.6279 mL 3.1397 mL 6.2794 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 2 mg/mL (6.28 mM); Clear solution; Need ultrasonic

    This protocol yields a clear solution of 2 mg/mL.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: 2 mg/mL (6.28 mM); Clear solution; Need ultrasonic

    This protocol yields a clear solution of 2 mg/mL.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1397 mL 15.6986 mL 31.3972 mL 78.4929 mL
5 mM 0.6279 mL 3.1397 mL 6.2794 mL 15.6986 mL
10 mM 0.3140 mL 1.5699 mL 3.1397 mL 7.8493 mL
15 mM 0.2093 mL 1.0466 mL 2.0931 mL 5.2329 mL
20 mM 0.1570 mL 0.7849 mL 1.5699 mL 3.9246 mL
25 mM 0.1256 mL 0.6279 mL 1.2559 mL 3.1397 mL
30 mM 0.1047 mL 0.5233 mL 1.0466 mL 2.6164 mL
40 mM 0.0785 mL 0.3925 mL 0.7849 mL 1.9623 mL
50 mM 0.0628 mL 0.3140 mL 0.6279 mL 1.5699 mL
60 mM 0.0523 mL 0.2616 mL 0.5233 mL 1.3082 mL
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Ivospemin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ivospemin748119-79-1SBP-101SBP101SBP 101Othersspermine analogtumorpolyamine catabolismornithine decarboxylaseInhibitorinhibitorinhibit

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