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  5. Jineol

Jineol  (Synonyms: 3,8-Quinolinediol)

Cat. No.: HY-119529 Purity: 99.22%
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Jineol is a cytotoxic alkaloid from the centipede Scolopendra subspinipes. Jineol exhibits modest cytotoxic activity in vitro against the growth of human tumor cell lines.

For research use only. We do not sell to patients.

Jineol Chemical Structure

Jineol Chemical Structure

CAS No. : 178762-28-2

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5 mg USD 175 In-stock
10 mg USD 280 In-stock
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Based on 1 publication(s) in Google Scholar

Jineol Related Antibodies

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Description

Jineol is a cytotoxic alkaloid from the centipede Scolopendra subspinipes. Jineol exhibits modest cytotoxic activity in vitro against the growth of human tumor cell lines[1].

Cellular Effect
Cell Line Type Value Description References
A549 ED50
5.8 μg/mL
Compound: 1
Cytotoxicity against human A549 cells by SRB assay
Cytotoxicity against human A549 cells by SRB assay
10.1021/np960188t
HCT-15 ED50
1.9 μg/mL
Compound: 1
Cytotoxicity against human HCT15 cells by SRB assay
Cytotoxicity against human HCT15 cells by SRB assay
10.1021/np960188t
SK-MEL-2 ED50
5.6 μg/mL
Compound: 1
Cytotoxicity against human SK-MEL-2 cells by SRB assay
Cytotoxicity against human SK-MEL-2 cells by SRB assay
10.1021/np960188t
SK-OV-3 ED50
4.5 μg/mL
Compound: 1
Cytotoxicity against human SKOV3 cells by SRB assay
Cytotoxicity against human SKOV3 cells by SRB assay
10.1021/np960188t
XF498 ED50
10 μg/mL
Compound: 1
Cytotoxicity against human XF498 cells by SRB assay
Cytotoxicity against human XF498 cells by SRB assay
10.1021/np960188t
Molecular Weight

161.16

Formula

C9H7NO2
CAS No.
Appearance

Solid

Color

Off-white to pink

SMILES

OC1=CC2=CC=CC(O)=C2N=C1
Structure Classification
Initial Source

Centipede Scolopendra subspinipes
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (620.50 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.2050 mL 31.0251 mL 62.0501 mL
5 mM 1.2410 mL 6.2050 mL 12.4100 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.22%

SDS (393 KB)

COA (250 KB) HNMR (237 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.2050 mL 31.0251 mL 62.0501 mL 155.1253 mL
5 mM 1.2410 mL 6.2050 mL 12.4100 mL 31.0251 mL
10 mM 0.6205 mL 3.1025 mL 6.2050 mL 15.5125 mL
15 mM 0.4137 mL 2.0683 mL 4.1367 mL 10.3417 mL
20 mM 0.3103 mL 1.5513 mL 3.1025 mL 7.7563 mL
25 mM 0.2482 mL 1.2410 mL 2.4820 mL 6.2050 mL
30 mM 0.2068 mL 1.0342 mL 2.0683 mL 5.1708 mL
40 mM 0.1551 mL 0.7756 mL 1.5513 mL 3.8781 mL
50 mM 0.1241 mL 0.6205 mL 1.2410 mL 3.1025 mL
60 mM 0.1034 mL 0.5171 mL 1.0342 mL 2.5854 mL
80 mM 0.0776 mL 0.3878 mL 0.7756 mL 1.9391 mL
100 mM 0.0621 mL 0.3103 mL 0.6205 mL 1.5513 mL
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Jineol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Jineol178762-28-23,8-QuinolinediolOtherscytotoxic alkaloidcentipedeScolopendra subspinipescytotoxictumorInhibitorinhibitorinhibit

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