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  4. ZL-12A probe

ZL-12A probe is a "stereoprobe "that can promote the degradation of TFIIH helicase ERCC3. ZL-12A degrades ERCC3 by covalently modifying C342.

For research use only. We do not sell to patients.

ZL-12A probe Chemical Structure

ZL-12A probe Chemical Structure

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1 mg USD 1280 In-stock
5 mg USD 3850 In-stock
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ZL-12A probe Related Antibodies

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Description

ZL-12A probe is a "stereoprobe "that can promote the degradation of TFIIH helicase ERCC3. ZL-12A degrades ERCC3 by covalently modifying C342[1].

Molecular Weight

385.46

Formula

C24H23N3O2
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1C[C@H](C2(C1)CN(C2)C(C3=CC=C4NC=CC4=C3)=O)C5=CC=CC=C5)C=C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (64.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5943 mL 12.9715 mL 25.9430 mL
5 mM 0.5189 mL 2.5943 mL 5.1886 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Purity & Documentation

Purity: 99.71%

Data Sheet (271 KB) SDS (251 KB)

COA (252 KB) RP-HPLC (224 KB) LCMS (96 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5943 mL 12.9715 mL 25.9430 mL 64.8576 mL
5 mM 0.5189 mL 2.5943 mL 5.1886 mL 12.9715 mL
10 mM 0.2594 mL 1.2972 mL 2.5943 mL 6.4858 mL
15 mM 0.1730 mL 0.8648 mL 1.7295 mL 4.3238 mL
20 mM 0.1297 mL 0.6486 mL 1.2972 mL 3.2429 mL
25 mM 0.1038 mL 0.5189 mL 1.0377 mL 2.5943 mL
30 mM 0.0865 mL 0.4324 mL 0.8648 mL 2.1619 mL
40 mM 0.0649 mL 0.3243 mL 0.6486 mL 1.6214 mL
50 mM 0.0519 mL 0.2594 mL 0.5189 mL 1.2972 mL
60 mM 0.0432 mL 0.2162 mL 0.4324 mL 1.0810 mL
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ZL-12A probe Related Classifications

Keywords:

ZL-12A probeFluorescent DyeTFIIHERCC3DegraderprobeInhibitorinhibitorinhibit

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