2. Metabolic Enzyme/Protease Neuronal Signaling Immunology/Inflammation GPCR/G Protein
  3. MAGL Histamine Receptor
  4. JZP-361

JZP-361 is a potent, reversible and selective inhibitor of human recombinant MAGL (hMAGL) with an IC50 of 46 nM. JZP-361 also shows antihistaminergic activities and can be used for asthma research.

For research use only. We do not sell to patients.

JZP-361 Chemical Structure

JZP-361 Chemical Structure

CAS No. : 1680193-80-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 88 In-stock
Solution
10 mM * 1 mL in DMSO USD 88 In-stock
Solid
5 mg USD 80 In-stock
10 mg USD 130 In-stock
25 mg USD 250 In-stock
50 mg USD 400 In-stock
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Based on 1 publication(s) in Google Scholar

JZP-361 Related Antibodies

Top Publications Citing Use of Products

View All Histamine Receptor Isoform Specific Products:

View All Isoforms
H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

JZP-361 is a potent, reversible and selective inhibitor of human recombinant MAGL (hMAGL) with an IC50 of 46 nM. JZP-361 also shows antihistaminergic activities and can be used for asthma research[1].

IC50 & Target

hMAGL

46 nM (IC50)

hABHD6

1.79 μM (IC50)

hFAAH

7.24 μM (IC50)

H1 Receptor

6.81 (pA2)

In Vitro

JZP-361 has almost 150-fold higher selectivity over human recombinant fatty acid amide hydrolase (hFAAH, IC50 = 7.24 μM) and 35-fold higher selectivity over human α/β-hydrolase-6 (hABHD6, IC50 = 1.79 μM)[1].
JZP-361 retains H1 antagonistic affinity (pA2 = 6.81) but did not show cannabinoid receptor activity, when tested at concentrations ≤10 μM[1].
JZP-361 displays favorable interactions within the active site of hMAGL including the important hydrogen-bonding of the carbonyl oxygen to the oxyanion hole[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JZP-361 Related Antibodies
Molecular Weight

405.88

Formula

C22H20ClN5O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N(CC/1)CCC1=C2C3=C(CCC4=C/2N=CC=C4)C=C(C=C3)Cl)N5N=CN=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (307.97 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4638 mL 12.3189 mL 24.6378 mL
5 mM 0.4928 mL 2.4638 mL 4.9276 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4638 mL 12.3189 mL 24.6378 mL 61.5946 mL
5 mM 0.4928 mL 2.4638 mL 4.9276 mL 12.3189 mL
10 mM 0.2464 mL 1.2319 mL 2.4638 mL 6.1595 mL
15 mM 0.1643 mL 0.8213 mL 1.6425 mL 4.1063 mL
20 mM 0.1232 mL 0.6159 mL 1.2319 mL 3.0797 mL
25 mM 0.0986 mL 0.4928 mL 0.9855 mL 2.4638 mL
30 mM 0.0821 mL 0.4106 mL 0.8213 mL 2.0532 mL
40 mM 0.0616 mL 0.3080 mL 0.6159 mL 1.5399 mL
50 mM 0.0493 mL 0.2464 mL 0.4928 mL 1.2319 mL
60 mM 0.0411 mL 0.2053 mL 0.4106 mL 1.0266 mL
80 mM 0.0308 mL 0.1540 mL 0.3080 mL 0.7699 mL
100 mM 0.0246 mL 0.1232 mL 0.2464 mL 0.6159 mL
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JZP-361 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JZP-3611680193-80-9JZP361JZP 361MAGLHistamine ReceptorMonoacylglycerol lipaseFAAHFatty acid amide hydrolaseABHD6antihistaminergicasthmaInhibitorinhibitorinhibit

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