L-690330 hydrate

Name: L-690330 hydrate
Brand: MedChemExpress
SKU: HY-101075A
Rating: 4.5 (1 reviews)

Cat. No.: HY-101075A Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

L-690330 hydrate is a competitive inhibitor of inositol monophosphatase (IMPase) with K_is of 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase, respectively. L-690330 hydrate exhibits 10-fold more sensitive than mouse and rat IMPase.

For research use only. We do not sell to patients.

L-690330 hydrate Chemical Structure

CAS No. : 2930564-26-2

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of L-690330 hydrate:

L-690330 Get quote

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Description

In Vitro

L-690330 hydrate (50 μM; 1 hour) induces P-AMPK and autophagy and increases LC3-I/II and p-AMPK expression in HEK293 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

L-690330 hydrate (intracerebroventricular?injection; 0.1 μmol) has no effects on their motor activity and coordination in the beam walking, except a reduction in time spent in light in the dark/light test^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Eight-week-old male ICR mice^[3]
Dosage:	0.1 μmol
Administration:	Intracerebroventricular injection
Result:	Did not effect mice well-being by i.c.v injection.

Molecular Weight

316.14

Formula

C₈H₁₄O₉P₂

CAS No.

2930564-26-2

Appearance

Solid

Color

Off-white to light yellow

SMILES

OC1=CC=C(OC(P(O)(O)=O)(P(O)(O)=O)C)C=C1.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (316.32 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 100 mg/mL (316.32 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1632 mL	15.8158 mL	31.6316 mL
5 mM	0.6326 mL	3.1632 mL	6.3263 mL
10 mM	0.3163 mL	1.5816 mL	3.1632 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.91 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.91 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (7.91 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (248 KB)

Handling Instructions (2659 KB)

References

[1]. Atack JR, et al. In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330. J Neurochem. 1993 Feb;60(2):652-8. [Content Brief]

[2]. Cárdenas C, et al. Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.Cell. 2010 Jul 23;142(2):270-83. [Content Brief]

[3]. Shtein L, et al. The inositol monophosphatase inhibitor L-690,330 affects pilocarpine-behavior and the forced swim test.Psychopharmacology (Berl). 2013 Jun;227(3):503-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	3.1632 mL	15.8158 mL	31.6316 mL	79.0789 mL
	5 mM	0.6326 mL	3.1632 mL	6.3263 mL	15.8158 mL
	10 mM	0.3163 mL	1.5816 mL	3.1632 mL	7.9079 mL
	15 mM	0.2109 mL	1.0544 mL	2.1088 mL	5.2719 mL
	20 mM	0.1582 mL	0.7908 mL	1.5816 mL	3.9539 mL
	25 mM	0.1265 mL	0.6326 mL	1.2653 mL	3.1632 mL
	30 mM	0.1054 mL	0.5272 mL	1.0544 mL	2.6360 mL
	40 mM	0.0791 mL	0.3954 mL	0.7908 mL	1.9770 mL
	50 mM	0.0633 mL	0.3163 mL	0.6326 mL	1.5816 mL
	60 mM	0.0527 mL	0.2636 mL	0.5272 mL	1.3180 mL
	80 mM	0.0395 mL	0.1977 mL	0.3954 mL	0.9885 mL
	100 mM	0.0316 mL	0.1582 mL	0.3163 mL	0.7908 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

L-690330 hydrate Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-6903302930564-26-2L690330L 690330PhosphataseLSDsensitivityimmobilitybehaviorInhibitorinhibitorinhibit

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L-690330 hydrate

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Other Forms of L-690330 hydrate:

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Complete Stock Solution Preparation Table

L-690330 hydrate Related Classifications

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