2. Anti-infection
  3. Bacterial
  4. Lacto-N-tetraose

Lacto-N-tetraose is the significant core structure of human milk oligosaccharides (HMOs) naturally existing in human milk. Lacto-N-tetraose is consist of galactose, N-acetylglucosamine, and glucose moieties. Lacto-N-tetraose has prebiotic effect, immune regulatory effect, anti-inflammatory effects, intestinal cell responses regulatory effect, antibacterial activity and antiviral activity. Lacto-N-tetraose has been widely added to infant formula.

For research use only. We do not sell to patients.

Lacto-N-tetraose Chemical Structure

Lacto-N-tetraose Chemical Structure

CAS No. : 14116-68-8

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Based on 1 publication(s) in Google Scholar

Lacto-N-tetraose Related Antibodies

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  • Purity & Documentation

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Description

Lacto-N-tetraose is the significant core structure of human milk oligosaccharides (HMOs) naturally existing in human milk. Lacto-N-tetraose is consist of galactose, N-acetylglucosamine, and glucose moieties. Lacto-N-tetraose has prebiotic effect, immune regulatory effect, anti-inflammatory effects, intestinal cell responses regulatory effect, antibacterial activity and antiviral activity. Lacto-N-tetraose has been widely added to infant formula[1].

In Vitro

HMOs exhibits antimicrobial and antibiofilm activity against Streptococcus agalactiae, antibiofilm activity against Methicillin-resistant Staphylococcus aureus (MRSA), and antimicrobial activity against both Acinetobacter baumannii and Clostridium difficile[2].
Lacto-N-tetraose (500-2000 μg/mL) does not cause clastogenic or aneugenic signs in human peripheral blood lymphocytes, nor increase the percentage of micronucleated cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lacto-N-tetraose Related Antibodies
In Vivo

Lacto-N-tetraose (1000-4000 mg/kg; p.o.; daily for 90 days) does not show toxicity in neonatal SD rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female neonatal SD rats (housed together with dam until weaning after 21 days)[3]
Dosage: 1000, 25000 and 4000 mg/kg 
Administration: p.o.; daily for 90 days
Result: Did not show toxicity on clinical observations, body weight, food consumption, development and maturation, clinical pathology, organ weights or histopathology.
Molecular Weight

707.63

Formula

C26H45NO21
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(N[C@H]([C@H]([C@@H]([C@H](O1)CO)O)O[C@@H]2O[C@@H]([C@@H]([C@@H]([C@H]2O)O)O)CO)[C@@H]1O[C@@H]3[C@H]([C@@H](O[C@@H]([C@@H]3O)CO)O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O)O)=O
Structure Classification
Initial Source

human
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (176.65 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4132 mL 7.0658 mL 14.1317 mL
5 mM 0.2826 mL 1.4132 mL 2.8263 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.4132 mL 7.0658 mL 14.1317 mL 35.3292 mL
5 mM 0.2826 mL 1.4132 mL 2.8263 mL 7.0658 mL
10 mM 0.1413 mL 0.7066 mL 1.4132 mL 3.5329 mL
15 mM 0.0942 mL 0.4711 mL 0.9421 mL 2.3553 mL
20 mM 0.0707 mL 0.3533 mL 0.7066 mL 1.7665 mL
25 mM 0.0565 mL 0.2826 mL 0.5653 mL 1.4132 mL
30 mM 0.0471 mL 0.2355 mL 0.4711 mL 1.1776 mL
40 mM 0.0353 mL 0.1766 mL 0.3533 mL 0.8832 mL
50 mM 0.0283 mL 0.1413 mL 0.2826 mL 0.7066 mL
60 mM 0.0236 mL 0.1178 mL 0.2355 mL 0.5888 mL
80 mM 0.0177 mL 0.0883 mL 0.1766 mL 0.4416 mL
100 mM 0.0141 mL 0.0707 mL 0.1413 mL 0.3533 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Lacto-N-tetraose Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lacto-N-tetraose14116-68-8BacterialmilkoligosaccharidesHMOsprebioticimmuneanti-inflammatoryintestinal cellantibacterialantiviralInhibitorinhibitorinhibit

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