2. Anti-infection Apoptosis
  3. Bacterial Fungal Apoptosis
  4. Lactoferrin (17-41) (acetate)

Lactoferrin (17-41) (acetate)  (Synonyms: Lactoferricin B acetate; Lfcin B acetate)

Cat. No.: HY-P1791B Purity: 99.49%
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Lactoferrin 17-41 (Lactoferricin B) acetate, a peptide corresponding to residues 17-41 of bovine lactoferrin, has antimicrobial activity against a wide range of microorganisms, including Gram-positive and Gramnegative bacteria, viruses, protozoa, and fungi. Lactoferrin 17-41 acetate has antitumor activities.

For research use only. We do not sell to patients.

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Lactoferrin (17-41) (acetate) Chemical Structure

Lactoferrin (17-41) (acetate) Chemical Structure

CAS No. : 2828433-30-1

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5 mg USD 120 In-stock
10 mg USD 200 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of Lactoferrin (17-41) (acetate):

Lactoferrin (17-41) (acetate) Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Lactoferrin 17-41 (Lactoferricin B) acetate, a peptide corresponding to residues 17-41 of bovine lactoferrin, has antimicrobial activity against a wide range of microorganisms, including Gram-positive and Gramnegative bacteria, viruses, protozoa, and fungi. Lactoferrin 17-41 acetate has antitumor activities[1][2].

In Vitro

Lactoferrin 17-41 (Lactoferricin B) acetate has an MIC of 30 μg/ml against E. coli ATCC 25922[1].
? Lactoferrin 17-41 acetate significantly stimulates apoptosis of HT-29 cells and displays cytotoxic activity on HT-29 cells[2].
? Lactoferrin 17-41 acetate variously regulats transcription of genes involved in the p53 signaling pathway, such as PMAIP-1, TP5313, and SFN[2].
? Lactoferrin 17-41 acetate can bind LPS from Gram-negative bacteria and that it can inhibit LPS induced cytokine response in human monocytic cells[1][3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lactoferrin (17-41) (acetate) Related Antibodies

Cell Viability Assay[1]

Cell Line: HT-29 cells
Concentration: 50, 100, 200, 400, 800 or 1000 µg/mL
Incubation Time: 4, 12, 24 or 48 hours
Result: More effective at inducing apoptosis at 400 µg/mL. Higher toxicity is shown at 800 µg/mL.
Molecular Weight

3183.82

Formula

C143H226N46O33S3
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Phe-Lys-Cys-Arg-Arg-Trp-Gln-Trp-Arg-Met-Lys-Lys-Leu-Gly-Ala-Pro-Ser-Ile-Thr-Cys-Val-Arg-Arg-Ala-Phe (Disulfide bridge: Cys3-Cys20)
Sequence Shortening

FKCRRWQWRMKKLGAPSITCVRRAF (Disulfide bridge: Cys3-Cys20)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 25.7 mg/mL (8.07 mM; Need ultrasonic and warming)

DMSO : 20 mg/mL (6.28 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3141 mL 1.5704 mL 3.1409 mL
5 mM 0.0628 mL 0.3141 mL 0.6282 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2 mg/mL (0.63 mM); Clear solution

    This protocol yields a clear solution of ≥ 2 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2 mg/mL (0.63 mM); Clear solution

    This protocol yields a clear solution of ≥ 2 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 0.3141 mL 1.5704 mL 3.1409 mL 7.8522 mL
5 mM 0.0628 mL 0.3141 mL 0.6282 mL 1.5704 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Lactoferrin (17-41) (acetate) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lactoferrin (17-41) (acetate)2828433-30-1Lactoferricin BLfcin BBacterialFungalApoptosisantimicrobialGram-positiveantitumorcytotoxicHT-29cellsLPSp53pathwaycancerInhibitorinhibitorinhibit

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