2. Membrane Transporter/Ion Channel Neuronal Signaling Anti-infection Autophagy Apoptosis Cell Cycle/DNA Damage PI3K/Akt/mTOR Protein Tyrosine Kinase/RTK
  3. TRP Channel HPV Autophagy Apoptosis PERK Akt Src
  4. Larixyl acetate

Larixyl acetate is a potent and selective TRPC6 inhibitor with IC50 values of 0.58 μM and 6.83 μM against hTRPC6-YFP and hTRPC3-YFP, respectively. Larixyl acetate prevents HPV and is effective in protecting against traumatic brain injury-induced systemic endothelial dysfunction.

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Larixyl acetate Chemical Structure

Larixyl acetate Chemical Structure

CAS No. : 4608-49-5

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Based on 2 publication(s) in Google Scholar

Other Forms of Larixyl acetate:

Larixyl acetate Related Antibodies

Top Publications Citing Use of Products

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TRPC TRPM TRPV TRPA TRPML

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Akt Akt1 Akt2 Akt3

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Lck Fyn Blk

  • Biological Activity

  • Purity & Documentation

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Description

Larixyl acetate is a potent and selective TRPC6 inhibitor with IC50 values of 0.58 μM and 6.83 μM against hTRPC6-YFP and hTRPC3-YFP, respectively. Larixyl acetate prevents HPV and is effective in protecting against traumatic brain injury-induced systemic endothelial dysfunction[1][2][3][4][5].

IC50 & Target

hTRPC6

0.58 μM (IC50)

hTRPC3

6.83 μM (IC50)

In Vitro

Larixyl acetate (1-10 μM, 3 minutes) exerts its anti-inflammatory activity by inhibiting the phosphorylation of ERK1/2, AKT, and Src, suppressing fMLP-induced neutrophil migration, and inhibiting the interaction between βγ subunits and Src or PLCβ[2].
Larixyl acetate (5 μM, 1 hour) effectively improves TBI-induced aortic endothelial dysfunction by inhibiting TRPC6 activity[3].
Larixyl acetate (5 μM, 72 hours) significantly reduces the expression of ER stress genes and improves cell function in a cardiac hypertrophy cell model (H9c2 rat cardiomyocytes induced by Ang II)[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Larixyl acetate Related Antibodies

Western Blot Analysis[2]

Cell Line: Human neutrophils
Concentration: 1, 2, 5, 10 μM
Incubation Time: 3 min
Result: Significantly inhibited fMLP-induced phosphorylation of ERK1/2, AKT, and Src.

Real Time qPCR[5]

Cell Line: H9c2 rat cardiomyocytes (cardiac hypertrophy model induced by Ang II (HY-13948))
Concentration: 5 μM
Incubation Time: 72 hours
Result: Significantly reduced the mRNA expression of cardiac hypertrophy-related genes (e.g., ANP, BNP, Myh7).
Significantly reduced the expression of ER stress-related genes GRP78, pPERK, ATF4, and CHOP.
In Vivo

Larixyl acetate (5 mg/kg, i.p., once dailly for 7 days) significantly improves aortic endothelial dysfunction in TBI mice by inhibiting TRPC6 activity, particularly enhancing acetylcholine-induced dilation[3].
Larixyl acetate (5 mg/kg, i.p., once daily for 4 weeks) improves cardiac function in pressure overload-induced heart failure model by inhibiting TRPC6, reducing cardiac hypertrophy, fibrosis, and apoptosis[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Closed-head mild traumatic brain injury (mTBI) model, C57BL/6, 129S, 129S-C57BL/6-F2 mice, TRPC6 knockout mice[3]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection (i.p.), once daily for 7 days
Result: Significantly improved aortic endothelial function 7 days after TBI.
Caused that acetylcholine (10 μM) induced dilation was significantly enhanced in Larixyl acetate-treated mice (In C57BL/6 mice, the Larixyl acetate group showed 96.9 %; in 129S-C57BL/6-F2 mice, the Larixyl acetate group showed 89.2 %).
Animal Model: Transverse aortic constriction (Tac) model for pressure overload-induced heart failure in mice[5]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection (i.p.), once daily for 4 weeks
Result: Significantly reduced cardiac hypertrophy, left ventricular pressure, and improved cardiac function (FS and EF increased).
Improved TAC-induced cardiac fibrosis, cardiomyocyte apoptosis, and inhibited ER stress-related proteins (e.g., GRP78) expression.
Molecular Weight

348.52

Formula

C22H36O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(CCC1)(C)[C@]([C@@]1(C)[C@H]2CC[C@](C)(O)C=C)([H])[C@@H](OC(C)=O)CC2=C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (286.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8693 mL 14.3464 mL 28.6928 mL
5 mM 0.5739 mL 2.8693 mL 5.7386 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Purity & Documentation

Purity: 99.46%

SDS (251 KB)

COA (250 KB) HNMR (270 KB) LCMS (97 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8693 mL 14.3464 mL 28.6928 mL 71.7319 mL
5 mM 0.5739 mL 2.8693 mL 5.7386 mL 14.3464 mL
10 mM 0.2869 mL 1.4346 mL 2.8693 mL 7.1732 mL
15 mM 0.1913 mL 0.9564 mL 1.9129 mL 4.7821 mL
20 mM 0.1435 mL 0.7173 mL 1.4346 mL 3.5866 mL
25 mM 0.1148 mL 0.5739 mL 1.1477 mL 2.8693 mL
30 mM 0.0956 mL 0.4782 mL 0.9564 mL 2.3911 mL
40 mM 0.0717 mL 0.3587 mL 0.7173 mL 1.7933 mL
50 mM 0.0574 mL 0.2869 mL 0.5739 mL 1.4346 mL
60 mM 0.0478 mL 0.2391 mL 0.4782 mL 1.1955 mL
80 mM 0.0359 mL 0.1793 mL 0.3587 mL 0.8966 mL
100 mM 0.0287 mL 0.1435 mL 0.2869 mL 0.7173 mL
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Larixyl acetate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Larixyl4608-49-5TRP ChannelHPVAutophagyApoptosisPERKAktSrcTransient receptor potential channelsHuman papillomavirusProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinasePKBProtein kinase BHEK 293systemic endothelial dysfunctionInhibitorinhibitorinhibit

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