LDV 

LDV is a non-fluorescent analog of LDV-FITC. LDV is a α4β1 integrin (VLA-4) ligand, and binds α4β1 integrin in leukemia cells^[1][2].

An LDV small molecule is well-characterized VLA-4 ligand that has been used to detect VLA-4 affinity and conformational changes^[1]. LDV is the minimum sequence of the CS-1 region of fibronectin necessary to bind α4β1 integrin^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

979.13

C₄₈H₇₀N₁₀O₁₂

1155866-55-9

Solid

White to off-white

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Ben H Njus, et al. Conformational mAb as a tool for integrin ligand discovery. Assay Drug Dev Technol. 2009 Oct;7(5):507-15.  [Content Brief]

  [2]. Estelle Gérard, et al. LDV peptidomimetics equipped with biotinylated spacer-arms: synthesis and biological evaluation on CCRF-CEM cell line. Bioorg Med Chem Lett. 2012 Jan 1;22(1):586-90.  [Content Brief]