2. PROTAC
  3. Ligands for E3 Ligase
  4. Lenalidomide-F

Lenalidomide-F is a E3 ligase ligand for LWY713. LWY713 is a PROTAC-class FLT3 degrader (DC50 = 0.64 nM), which selectively induces FLT3 degradation via cereblon and proteasome-dependent pathways.

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Lenalidomide-F Chemical Structure

Lenalidomide-F Chemical Structure

CAS No. : 2359705-88-5

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Based on 1 publication(s) in Google Scholar

Lenalidomide-F Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1

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Description

Lenalidomide-F is a E3 ligase ligand for LWY713. LWY713 is a PROTAC-class FLT3 degrader (DC50 = 0.64 nM), which selectively induces FLT3 degradation via cereblon and proteasome-dependent pathways[1].

IC50 & Target

Cereblon

 

Molecular Weight

262.24

Formula

C13H11FN2O3
CAS No.
Appearance

Solid

SMILES

O=C(C(N(CC1=C2C=CC=C1F)C2=O)CC3)NC3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Purity & Documentation
References
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Lenalidomide-F Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lenalidomide-F2359705-88-5Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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