Loxoprofen-d₃

Cat. No.: HY-W654009: Data Sheet Handling Instructions Technical Support

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Loxoprofen-d₃ is deuterium labeled Loxoprofen. Loxoprofen is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen is a nonselective COX inhibitor with IC₅₀s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. Loxoprofen can reduce atherosclerosis and shows antitumor activity.

For research use only. We do not sell to patients.

Loxoprofen-d<sub>3</sub> Chemical Structure

Loxoprofen-d₃ Chemical Structure

Size	Stock	Quantity
1 mg	Get quote 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
5 mg	Get quote
10 mg	Get quote

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Other Forms of Loxoprofen-d₃:

Loxoprofen In-stock

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COX COX-1 COX-2 COX-3

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Description

Molecular Weight

249.32

Formula

C₁₅H₁₅D₃O₃

Unlabeled CAS

68767-14-6

SMILES

O=C1CCCC1CC2=CC=C(C=C2)C(C(O)=O)C([2H])([2H])[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (401.09 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.0109 mL	20.0545 mL	40.1091 mL
5 mM	0.8022 mL	4.0109 mL	8.0218 mL
10 mM	0.4011 mL	2.0055 mL	4.0109 mL

View the Complete Stock Solution Preparation Table

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Purity & Documentation

Data Sheet (274 KB) Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

[2]. Hamaguchi M, et al. Loxoprofen Sodium, a Non-Selective NSAID, Reduces Atherosclerosis in Mice by Reducing Inflammation. J Clin Biochem Nutr. 2010 Sep;47(2):138-47. [Content Brief]

[3]. Riendeau D, et al. Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2. Bioorg Med Chem Lett. 2004;14(5):1201-1203. [Content Brief]

[4]. Kanda A, et al. Loxoprofen sodium suppresses mouse tumor growth by inhibiting vascular endothelial growth factor. Acta Oncol. 2003;42(1):62-70. [Content Brief]

[5]. Paudel S, et al. Assessing Drug Interaction and Pharmacokinetics of Loxoprofen in Mice Treated with CYP3A Modulators. Pharmaceutics. 2019;11(9):479. Published 2019 Sep 16. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.0109 mL	20.0545 mL	40.1091 mL	100.2727 mL
	5 mM	0.8022 mL	4.0109 mL	8.0218 mL	20.0545 mL
	10 mM	0.4011 mL	2.0055 mL	4.0109 mL	10.0273 mL
	15 mM	0.2674 mL	1.3370 mL	2.6739 mL	6.6848 mL
	20 mM	0.2005 mL	1.0027 mL	2.0055 mL	5.0136 mL
	25 mM	0.1604 mL	0.8022 mL	1.6044 mL	4.0109 mL
	30 mM	0.1337 mL	0.6685 mL	1.3370 mL	3.3424 mL
	40 mM	0.1003 mL	0.5014 mL	1.0027 mL	2.5068 mL
	50 mM	0.0802 mL	0.4011 mL	0.8022 mL	2.0055 mL
	60 mM	0.0668 mL	0.3342 mL	0.6685 mL	1.6712 mL
	80 mM	0.0501 mL	0.2507 mL	0.5014 mL	1.2534 mL
	100 mM	0.0401 mL	0.2005 mL	0.4011 mL	1.0027 mL

Loxoprofen-d₃ Related Classifications

Inflammation/Immunology

Keywords:

Loxoprofen-d₃Isotope-Labeled CompoundsCOXCyclooxygenaseInhibitorinhibitorinhibit

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Loxoprofen-d3

Other Forms of Loxoprofen-d3:

View All COX Isoform Specific Products:

Biological Activity

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