LQZ-7I

Name: LQZ-7I
Brand: MedChemExpress
SKU: HY-136538
Rating: 4.5 (1 reviews)

Cat. No.: HY-136538 Purity: 99.88%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

LQZ-7I is a survivin-targeting inhibitor. LQZ-7I inhibits survivin dimerization. LQZ-7I orally effectively inhibits xenograft tumor growth and induces survivin loss in tumors.

For research use only. We do not sell to patients.

LQZ-7I Chemical Structure

CAS No. : 195822-23-2

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 66	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 66	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 320	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 500	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

LQZ-7I is a survivin-targeting inhibitor. LQZ-7I inhibits survivin dimerization. LQZ-7I orally effectively inhibits xenograft tumor growth and induces survivin loss in tumors^[1].

IC₅₀ & Target

Survivin^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
LNCaP C4-2	IC₅₀	2 μM Compound: LQZ-7I; 7I	Cytotoxicity against human C4-2 cells transfected with pcDNA3.1 assessed as reduction in cell viability measured after 72 hrs by methylene blue staining based assay Cytotoxicity against human C4-2 cells transfected with pcDNA3.1 assessed as reduction in cell viability measured after 72 hrs by methylene blue staining based assay	[PMID: 32421328]
LNCaP C4-2	IC₅₀	3.1 μM Compound: LQZ-7I; 7I	Cytotoxicity against human C4-2 cells assessed as reduction in cell viability measured after 72 hrs by methylene blue staining based assay Cytotoxicity against human C4-2 cells assessed as reduction in cell viability measured after 72 hrs by methylene blue staining based assay	[PMID: 32421328]
LNCaP C4-2	IC₅₀	7 μM Compound: LQZ-7I; 7I	Cytotoxicity against human C4-2 cells transfected with HA-tagged survivin assessed as reduction in cell viability measured after 72 hrs by methylene blue staining based assay Cytotoxicity against human C4-2 cells transfected with HA-tagged survivin assessed as reduction in cell viability measured after 72 hrs by methylene blue staining based assay	[PMID: 32421328]
PC-3	IC₅₀	4.8 μM Compound: LQZ-7I; 7I	Cytotoxicity against human PC3 cells assessed as reduction in cell viability measured after 72 hrs by methylene blue staining based assay Cytotoxicity against human PC3 cells assessed as reduction in cell viability measured after 72 hrs by methylene blue staining based assay	[PMID: 32421328]

In Vitro

LQZ-7I has improved cytotoxicity with IC₅₀s of 3.1 µM against C4-2 cells and 4.8 µM against PC-3 cells compared with the parent compound LQZ-7^[1].
LQZ-7I (10 µM; 0-6 hours) treatment reduces the expression of survivin. However, LQZ-7I does not reduce the expression of XIAP, CIAP1, and CIAP2. LQZ-7I may be selective to its intended target survivin^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	PC-3 or C4-2 cells
Concentration:	10 µM
Incubation Time:	0-6 hours
Result:	Reduced the expression of survivin.

In Vivo

LQZ-7I (100 mg/kg; oral gavage every other day for a total of ten treatments) significantly suppresses tumor growth without any notable adverse effect on the mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6-week old male NSG mice^[1]
Dosage:	100 mg/kg; 200 µL vehicle (90% corn oil/10% DMSO)
Administration:	Oral gavage every other day for a total of ten treatments
Result:	Significantly suppressed tumor growth without any notable adverse effect on the mice as indicated by lacking changes in body weight and in wet weight of major organs at the end of the study.

Molecular Weight

348.35

Formula

C₂₀H₁₄F₂N₄

CAS No.

195822-23-2

Appearance

Solid

Color

Light yellow to green yellow

SMILES

FC1=CC=C(NC2=NC3=CC=CC=C3N=C2NC4=CC=C(F)C=C4)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (358.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8707 mL	14.3534 mL	28.7068 mL
5 mM	0.5741 mL	2.8707 mL	5.7414 mL
10 mM	0.2871 mL	1.4353 mL	2.8707 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (5.97 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.88%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (251 KB) LCMS (267 KB)

Handling Instructions (2659 KB)

References

[1]. Robert Peery,et al. Synthesis and Identification of a Novel Lead Targeting Survivin Dimerization for Proteasome-Dependent Degradation. J Med Chem. 2020 Jun 9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8707 mL	14.3534 mL	28.7068 mL	71.7669 mL
	5 mM	0.5741 mL	2.8707 mL	5.7414 mL	14.3534 mL
	10 mM	0.2871 mL	1.4353 mL	2.8707 mL	7.1767 mL
	15 mM	0.1914 mL	0.9569 mL	1.9138 mL	4.7845 mL
	20 mM	0.1435 mL	0.7177 mL	1.4353 mL	3.5883 mL
	25 mM	0.1148 mL	0.5741 mL	1.1483 mL	2.8707 mL
	30 mM	0.0957 mL	0.4784 mL	0.9569 mL	2.3922 mL
	40 mM	0.0718 mL	0.3588 mL	0.7177 mL	1.7942 mL
	50 mM	0.0574 mL	0.2871 mL	0.5741 mL	1.4353 mL
	60 mM	0.0478 mL	0.2392 mL	0.4784 mL	1.1961 mL
	80 mM	0.0359 mL	0.1794 mL	0.3588 mL	0.8971 mL
	100 mM	0.0287 mL	0.1435 mL	0.2871 mL	0.7177 mL

LQZ-7I Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LQZ-7I195822-23-2SurvivinsurvivindimerizationtumorInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

LQZ-7I

Customer Review

LQZ-7I Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

LQZ-7I Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

LQZ-7I Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report