2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Lubabegron

Lubabegron  (Synonyms: LY-488756)

Cat. No.: HY-123012 Purity: 98.21%
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Lubabegron is a potent modulator of β-adrenergic receptor (β -AR). Lubabegron demonstrates antagonistic behavior at the β1 and β 2 receptor subtypes and agonistic behavior at the β 3 receptor subtype in cattle. Lubabegron reduces NH3 gas emissions from an animal or its waste.

For research use only. We do not sell to patients.

Lubabegron Chemical Structure

Lubabegron Chemical Structure

CAS No. : 391920-32-4

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1 mg USD 140 In-stock
5 mg USD 350 In-stock
10 mg USD 600 In-stock
25 mg USD 1250 In-stock
50 mg USD 1950 In-stock
100 mg USD 3200 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Lubabegron:

Lubabegron Related Antibodies

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α adrenergic receptor β adrenergic receptor

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Description

Lubabegron is a potent modulator of β-adrenergic receptor (β -AR). Lubabegron demonstrates antagonistic behavior at the β1 and β 2 receptor subtypes and agonistic behavior at the β 3 receptor subtype in cattle. Lubabegron reduces NH3 gas emissions from an animal or its waste[1].

IC50 & Target

β adrenergic receptor

 

Molecular Weight

499.62

Formula

C29H29N3O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N#CC1=CC=CN=C1OC2=CC=C(C=C2)CC(NC[C@@H](COC3=CC=CC=C3C4=CC=CS4)O)(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (200.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0015 mL 10.0076 mL 20.0152 mL
5 mM 0.4003 mL 2.0015 mL 4.0030 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0015 mL 10.0076 mL 20.0152 mL 50.0380 mL
5 mM 0.4003 mL 2.0015 mL 4.0030 mL 10.0076 mL
10 mM 0.2002 mL 1.0008 mL 2.0015 mL 5.0038 mL
15 mM 0.1334 mL 0.6672 mL 1.3343 mL 3.3359 mL
20 mM 0.1001 mL 0.5004 mL 1.0008 mL 2.5019 mL
25 mM 0.0801 mL 0.4003 mL 0.8006 mL 2.0015 mL
30 mM 0.0667 mL 0.3336 mL 0.6672 mL 1.6679 mL
40 mM 0.0500 mL 0.2502 mL 0.5004 mL 1.2510 mL
50 mM 0.0400 mL 0.2002 mL 0.4003 mL 1.0008 mL
60 mM 0.0334 mL 0.1668 mL 0.3336 mL 0.8340 mL
80 mM 0.0250 mL 0.1251 mL 0.2502 mL 0.6255 mL
100 mM 0.0200 mL 0.1001 mL 0.2002 mL 0.5004 mL
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Lubabegron Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lubabegron391920-32-4LY-488756LY488756LY 488756Adrenergic ReceptorBeta Receptorβ-adrenergicβ-ARantagonisticcattleNH3 gas emissionanimalwasteInhibitorinhibitorinhibit

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