Lys-(Des-Arg9,Leu8)-Bradykinin

Cat. No.: HY-P4676 Purity: 98.23%: FAQs
Data Sheet SDS COA Handling Instructions

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Lys-(Des-Arg9,Leu8)-Bradykinin is a bradykinin B1 receptor antagonist.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Lys-(Des-Arg9,Leu8)-Bradykinin Chemical Structure

CAS No. : 71800-37-8

Size	Price	Stock	Quantity
5 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 190	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Bradykinin B1 Receptor (B1R) Bradykinin B2 Receptor (B2R)

Biological Activity
Purity & Documentation
References
Customer Review

Description

Lys-(Des-Arg9,Leu8)-Bradykinin is a bradykinin B1 receptor antagonist^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	0.99 μM Compound: DALK(BA)	Antagonist activity against bradykinin B1 receptor in human HeLa cells assessed as inhibition of Des-Arg9-BK-induced increase in intracellular Ca2+ level by Fluro-4 direct calcium dye based fluorescence assay Antagonist activity against bradykinin B1 receptor in human HeLa cells assessed as inhibition of Des-Arg9-BK-induced increase in intracellular Ca2+ level by Fluro-4 direct calcium dye based fluorescence assay	[PMID: 27977181]

Molecular Weight

998.18

Formula

C₄₇H₇₅N₁₃O₁₁

CAS No.

71800-37-8

Appearance

Solid

Color

White to off-white

Sequence

Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Leu

Sequence Shortening

KRPPGFSPL

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (50.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0018 mL	5.0091 mL	10.0182 mL
5 mM	0.2004 mL	1.0018 mL	2.0036 mL
10 mM	0.1002 mL	0.5009 mL	1.0018 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.23%

Select Batch:

Data Sheet (277 KB) SDS (252 KB)

COA (260 KB) RP-HPLC (111 KB) MS (224 KB)

Handling Instructions (2659 KB)

References

[1]. Gieldon A, et, al. Theoretical study of the human bradykinin-bradykinin B2 receptor complex. Chembiochem. 2008 Oct 13;9(15):2487-97. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0018 mL	5.0091 mL	10.0182 mL	25.0456 mL
	5 mM	0.2004 mL	1.0018 mL	2.0036 mL	5.0091 mL
	10 mM	0.1002 mL	0.5009 mL	1.0018 mL	2.5046 mL
	15 mM	0.0668 mL	0.3339 mL	0.6679 mL	1.6697 mL
	20 mM	0.0501 mL	0.2505 mL	0.5009 mL	1.2523 mL
	25 mM	0.0401 mL	0.2004 mL	0.4007 mL	1.0018 mL
	30 mM	0.0334 mL	0.1670 mL	0.3339 mL	0.8349 mL
	40 mM	0.0250 mL	0.1252 mL	0.2505 mL	0.6261 mL
	50 mM	0.0200 mL	0.1002 mL	0.2004 mL	0.5009 mL