2. Metabolic Enzyme/Protease Anti-infection Immunology/Inflammation NF-κB
  3. Endogenous Metabolite Glycosidase Bacterial Interleukin Related Reactive Oxygen Species
  4. Mannan

Mannan is an orally active polysaccharide compound that binds to the mannose receptor (MR). Mannan promotes bacterial uptake and endosomal degradation by binding to MR, thereby enhancing the production of IL-12 in immune cells. Mannan enhances ROS production. Mannan modulates immunity, inhibits Aflatoxin B1 (HY-N6615)-induced toxicity, and reduces lipid.

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Mannan Chemical Structure

Mannan Chemical Structure

CAS No. : 9036-88-8

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Mannan Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Mannan

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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Description

Mannan is an orally active polysaccharide compound that binds to the mannose receptor (MR). Mannan promotes bacterial uptake and endosomal degradation by binding to MR, thereby enhancing the production of IL-12 in immune cells. Mannan enhances ROS production. Mannan modulates immunity, inhibits Aflatoxin B1 (HY-N6615)-induced toxicity, and reduces lipid[1][2][3][4].

In Vitro

Mannan (10-100 μg/mL, 30 min) enhances the IL-12 production by increasing bacterial uptake and endosomal degradation in L. acidophilus and S. aureus stimulated dendritic cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mannan Related Antibodies

Western Blot Analysis[1]

Cell Line: Murine bone marrow-derived dendritic cells (BMDCs)
Concentration: 10 µg/mL, 100 µg/mL
Incubation Time: 30 min for pretreatment before bacteria stimulation; 60 min before adding bacteria for endocytosis assay; 1 h for MR surface expression assay
Result: Led to a decrease in the surface expression of the mannose receptor (MR) detected.

Real Time qPCR[1]

Cell Line: Murine bone marrow-derived dendritic cells (BMDCs)
Concentration: 10 µg/mL, 100 µg/mL
Incubation Time: 30 min for pretreatment before bacteria stimulation; 60 min before adding bacteria for endocytosis assay; 1 h for MR surface expression assay
Result: Increased the expression of IFN-β in cells stimulated with L. acidophilus.
In Vivo

Mannan (50-500 ppm; p.o., dietary; daily; 4 weeks) reduces Aflatoxin B1 (HY-N6615)-induced toxicity in mice, as evidenced by increased body weight, decreased rate of normochromatic erythrocytes with micronuclei, and decreased rate of sister chromatid exchanges[2].
Mannan (50-100 mg/kg; i.p.; 2-5 times) reduces serum levels of low-density lipoprotein (LDL), cholesterol, and triglycerides in mice with acute dyslipidemia induced by poloxamer 407 (HY-D1005)[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CBA/Lac mice (2.5-3-month-old, weighing 22-25 g), acute lipemia induced by poloxamer 407 model[4]
Dosage: 50 mg/kg, 100 mg/kg
Administration: Intraperitoneal injection, 5 times at 50 mg/kg every other day or 2 times at 100 mg/kg with 1-day interval
Result: Reduced the levels of triglyceride, atherogenic LDL, and total cholesterol in the serum at 50 mg/kg and 100 mg/kg.
Decreased the triglyceride concentration in the liver.
Increased the lability of lysosomal membranes in the liver and elevated the serum activity of chitotriosidase, a marker of macrophage activation.
Clinical Trial
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

[Mannan]
Structure Classification
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Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (Need ultrasonic)

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Purity & Documentation

Purity: 98.10%

SDS (393 KB)

COA (244 KB)

Handling Instructions (2659 KB)
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Mannan Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mannan9036-88-8Endogenous MetaboliteGlycosidaseBacterialInterleukin RelatedReactive Oxygen SpeciesILbiochemical assayreagentInhibitorinhibitorinhibit

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