2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. MAX-10181

MAX-10181  (Synonyms: PD-1/PD-L1-IN-30)

Cat. No.: HY-153064 Purity: 98.07%
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MAX-10181 (PD-1/PD-L1-IN-30) is a PD-1/PD-L1 binding inhibitor, with an IC50 value of 0.018 μM. MAX-10181 can be used for research of cancers and other related diseases.

For research use only. We do not sell to patients.

MAX-10181 Chemical Structure

MAX-10181 Chemical Structure

CAS No. : 2171558-14-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 406 In-stock
Solution
10 mM * 1 mL in DMSO USD 406 In-stock
Solid
5 mg USD 350 In-stock
10 mg USD 600 In-stock
25 mg USD 1150 In-stock
50 mg USD 1800 In-stock
100 mg USD 2850 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

MAX-10181 Related Antibodies

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Description

MAX-10181 (PD-1/PD-L1-IN-30) is a PD-1/PD-L1 binding inhibitor, with an IC50 value of 0.018 μM. MAX-10181 can be used for research of cancers and other related diseases[1].

In Vitro

MAX-10181 (Example 68) inhibits PD-1/PD-L1 binding with an IC50 value of 0.018 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MAX-10181 Related Antibodies
Clinical Trial
Molecular Weight

527.53

Formula

C29H28F3NO5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=C(C=CC=C1/C=C/C2=C(C=CC(CNC(CO)(C)C(O)=O)=C2)C(F)(F)F)C3=CC=C(OCCO4)C4=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (189.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8956 mL 9.4781 mL 18.9563 mL
5 mM 0.3791 mL 1.8956 mL 3.7913 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8956 mL 9.4781 mL 18.9563 mL 47.3907 mL
5 mM 0.3791 mL 1.8956 mL 3.7913 mL 9.4781 mL
10 mM 0.1896 mL 0.9478 mL 1.8956 mL 4.7391 mL
15 mM 0.1264 mL 0.6319 mL 1.2638 mL 3.1594 mL
20 mM 0.0948 mL 0.4739 mL 0.9478 mL 2.3695 mL
25 mM 0.0758 mL 0.3791 mL 0.7583 mL 1.8956 mL
30 mM 0.0632 mL 0.3159 mL 0.6319 mL 1.5797 mL
40 mM 0.0474 mL 0.2370 mL 0.4739 mL 1.1848 mL
50 mM 0.0379 mL 0.1896 mL 0.3791 mL 0.9478 mL
60 mM 0.0316 mL 0.1580 mL 0.3159 mL 0.7898 mL
80 mM 0.0237 mL 0.1185 mL 0.2370 mL 0.5924 mL
100 mM 0.0190 mL 0.0948 mL 0.1896 mL 0.4739 mL
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MAX-10181 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAX-101812171558-14-6PD-1/PD-L1-IN-30MAX10181MAX 10181PD-1/PD-L1PD-1/Programmed death-ligand 1CancerPD-1PD-L1Inhibitorinhibitorinhibit

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