2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Drug-Linker Conjugates for ADC Topoisomerase
  4. MC-Gly-Gly-Phe-Gly-amide-cyclopropanol-amide-Exatecan

MC-Gly-Gly-Phe-Gly-amide-cyclopropanol-amide-Exatecan 

Cat. No.: HY-150402 Purity: 95.03%
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MC-Gly-Gly-Phe-Gly-amide-cyclopropanol-amide-Exatecan is a pharmaceutical composition containing antibody agent conjugate (ADC). (extracted from patent WO2021190581 Example 1-8).

For research use only. We do not sell to patients.

MC-Gly-Gly-Phe-Gly-amide-cyclopropanol-amide-Exatecan Chemical Structure

MC-Gly-Gly-Phe-Gly-amide-cyclopropanol-amide-Exatecan Chemical Structure

CAS No. : 2414254-41-2

Size Price Stock Quantity
1 mg USD 226 In-stock
5 mg USD 680 In-stock
10 mg USD 1080 In-stock
25 mg USD 2160 In-stock
50 mg USD 3348 In-stock
100 mg   Get quote  
200 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

MC-Gly-Gly-Phe-Gly-amide-cyclopropanol-amide-Exatecan Related Antibodies

Top Publications Citing Use of Products

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Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

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Topoisomerase Topo I Topo II

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Description

MC-Gly-Gly-Phe-Gly-amide-cyclopropanol-amide-Exatecan is a pharmaceutical composition containing antibody agent conjugate (ADC). (extracted from patent WO2021190581 Example 1-8)[1].

IC50 & Target

Camptothecins

 

Molecular Weight

1060.09

Formula

C54H58FN9O13
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1(CC1)OCNC(CNC([C@@H](NC(CNC(CNC(CCCCCN2C(C=CC2=O)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)N[C@@H]4C5=C6C(C(N7C6)=CC([C@](O)(C(OC8)=O)CC)=C8C7=O)=NC9=CC(F)=C(C)C(CC4)=C95
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 60 mg/mL (56.60 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9433 mL 4.7166 mL 9.4332 mL
5 mM 0.1887 mL 0.9433 mL 1.8866 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9433 mL 4.7166 mL 9.4332 mL 23.5829 mL
5 mM 0.1887 mL 0.9433 mL 1.8866 mL 4.7166 mL
10 mM 0.0943 mL 0.4717 mL 0.9433 mL 2.3583 mL
15 mM 0.0629 mL 0.3144 mL 0.6289 mL 1.5722 mL
20 mM 0.0472 mL 0.2358 mL 0.4717 mL 1.1791 mL
25 mM 0.0377 mL 0.1887 mL 0.3773 mL 0.9433 mL
30 mM 0.0314 mL 0.1572 mL 0.3144 mL 0.7861 mL
40 mM 0.0236 mL 0.1179 mL 0.2358 mL 0.5896 mL
50 mM 0.0189 mL 0.0943 mL 0.1887 mL 0.4717 mL
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MC-Gly-Gly-Phe-Gly-amide-cyclopropanol-amide-Exatecan Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MC-Gly-Gly-Phe-Gly-amide-cyclopropanol-amide-Exatecan2414254-41-2Drug-Linker Conjugates for ADCTopoisomeraseInhibitorinhibitorinhibit

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