2. JAK/STAT Signaling Stem Cell/Wnt
  3. STAT
  4. MC0704

MC0704 is a STAT3 inhibitor with an IC50 value of 2.13 μM. MC0704 induces cell apoptosis and cell cycle arrest. MC0704 shows antitumor activity in mouse breast cancer models. MC0704 can be used for the research of metastatic triple-negative breast cancer (mTNBC).

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MC0704 Chemical Structure

MC0704 Chemical Structure

CAS No. : 3034176-57-0

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Description

MC0704 is a STAT3 inhibitor with an IC50 value of 2.13 μM. MC0704 induces cell apoptosis and cell cycle arrest. MC0704 shows antitumor activity in mouse breast cancer models. MC0704 can be used for the research of metastatic triple-negative breast cancer (mTNBC)[1].

In Vitro

MC0704 (0-50 μM; 72 h) shows cytotoxicity to HEK-293, lung epithelial normal (MRC-5), MDA-MB 231, MDA-MB-231 paclitaxel-resistant (MDA-MB-231-PTR) and MDA-MB-231 docetaxel-resistant (MDA-MB-231-DTR) cells with IC50 values of 3.11, 33.25, 2.98, 3.24 and 2.87 μM, respectively[1].
MC0704 (0, 0.4, 2, 10 and 50 μM; 24 h) inhibits activity of STAT3 with an IC50 value of 2.13 μM[1].
MC0704 (5 μM; 24 h) suppresses the activation of STAT3[1].
MC0704 (0, 2.5, 5 and 10 μM; 36-48 h) increases the cell cycle arrest at the G2/M phase and induces apoptosis in MDA-MB-231-DTR cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MC0704 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HEK-293 and MRC-5 cell lines
Concentration: 0-50 μM
Incubation Time: 72 hours
Result: Showed cytotoxicity to HEK-293 and MRC-5 cells.

Western Blot Analysis[1]

Cell Line: MDA-MB-231 TNBC cell line
Concentration: 5 μM
Incubation Time: 24 hour
Result: Inhibited the expression of p-STAT3.
In Vivo

MC0704 (10 mg/kg; i.p., 10 mg/kg, once daily for 12 days) inhibits cancer growth of mice with MDA-MB-231-DTR cells transplant[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c-nu mice with MDA-MB-231-DTR cells transplant[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; 10 mg/kg, once daily for 12 days
Result: Significantly inhibited tumor growth without overt toxicity, and reversed the mesenchymal marker vimentin and epithelial marker E-cadherin expression changes.
Molecular Weight

537.41

Formula

C29H21BrN4O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=NC(C(NCCC2=CNC3=C2C=CC=C3)=O)=CC4=C1NC5=CC=CC=C54)C6=CC=C(C=C6)Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (46.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8608 mL 9.3039 mL 18.6078 mL
5 mM 0.3722 mL 1.8608 mL 3.7216 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8608 mL 9.3039 mL 18.6078 mL 46.5194 mL
5 mM 0.3722 mL 1.8608 mL 3.7216 mL 9.3039 mL
10 mM 0.1861 mL 0.9304 mL 1.8608 mL 4.6519 mL
15 mM 0.1241 mL 0.6203 mL 1.2405 mL 3.1013 mL
20 mM 0.0930 mL 0.4652 mL 0.9304 mL 2.3260 mL
25 mM 0.0744 mL 0.3722 mL 0.7443 mL 1.8608 mL
30 mM 0.0620 mL 0.3101 mL 0.6203 mL 1.5506 mL
40 mM 0.0465 mL 0.2326 mL 0.4652 mL 1.1630 mL
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MC0704 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MC07043034176-57-0MC 0704MC-0704STATβ-carbolineapoptosiscell cycle arrestantitumormTNBCInhibitorinhibitorinhibit

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